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Biomedical subjects

R Abe

Publications and source records attributed to R Abe.

At least 379 records · Page 21Linked to original sources
PubMed1987

[Thermochemotherapy of unresectable pancreatic carcinoma (hot water and intra-arterial chemotherapy using noradrenaline)].

A 86-year-old man with unresectable pancreatic carcinoma was treated with thermochemotherapy. In most of the body and tail affected by the tumor, which did not show any cytotoxic damage after intraarterial chemotherapy, an enhanced antitumor effect was achieved by hyperthermia, which heated the tumor using hot water in a balloon placed on the pancreas, and which was delivered through a vinyl tube leading out of the body for 40 minutes while administration of antitumor agents mixed with noradrenaline was simultaneously given into the celiac artery. In this case, we observed that using noradrenaline with contrast material injected into the celiac artery it was possible to delineate the tumor area by computed tomography of the pancreas.

Aged↗
PubMed1987

Malignant melanoma of mucous membranes. A clinicopathologic study of 13 cases in Japanese patients.

We found 13 mucosal melanomas (13%) among 103 cases of malignant melanoma at Tohoku University Hospital, Sendai, Japan, a high incidence. Five melanomas were found on the oral mucosa, another five on the genital mucosa, two within the nasal cavity, and one on the esophagus. Three of the melanomas on the oral mucosa occurred on the lip and the other two on the gingiva. A striking prevalence of melanomas was observed in women, the male-to-female ratio being 0.08. Histologic examination revealed that 58% of the melanomas were characterized by lentiginous, 23% by nodular, and 15% by superficial spreading proliferation. Most of the melanomas were Clark's level IV or V at the time of diagnosis. Except for three who have been under observation for a short time, all the patients have died. There appear to be some clinical and histologic similarities between mucosal melanoma and melanoma of the volar skin, but the difference in biological behavior warrants that the two be classified separately.

Adult↗
PubMed1987

[Follicular carcinoma in an autonomously functioning thyroid nodule].

The patient was a 66-year-old man who complained of goiter. A diagnosis of functioning thyroid tumor was made because of high uptake of 131I after T3 suppression test and no response to thyrotropin releasing hormone. The tumor was removed and histologically proven to be follicular carcinoma. Twelve cases of thyroid carcinoma in autonomously functioning thyroid nodules have been reported, and the relation between carcinoma and an autonomously functioning nodule is reviewed from the literature.

Adenocarcinoma↗
PubMed1986

Myeloblastoma with an 8;21 chromosome translocation in acute myeloblastic leukemia.

An 8;21 chromosome translocation was found in cells from myeloblastomas of two acute myeloblastic leukemia (AML) patients. In one patient, a sudden onset of paraplegia, which was caused by an epidural myeloblastoma in the thoracic vertebral canal, was the initial symptom of the disease and that of the first relapse. In the other, myeloblastomas, which occurred in the breasts during a hematologic remission, heralded the first relapse. Karyotypes of tumor cells obtained from both patients showed the t(8;21) and additional chromosome abnormalities. These findings, together with earlier experience and reports in the literature, indicate that myeloblastoma may be unique to the 8;21 translocation, and that certain chromosomal abnormalities additional to the t(8;21) may be necessary for the tumor formation.

Adolescent↗
PubMed1986

Promyelocytic crisis of chronic myelogenous leukemia without t(15;17).

A case of promyelocytic crisis of chronic myelogenous leukemia is reported. The amount of promyelocytoid blasts in peripheral blood and bone marrow were 70% and 58%, respectively, at the onset of the blastic phase. Cytogenetic analyses during the blastic phase did not reveal t(15;17); however, t(3;21) in addition to the t(9;22) in the karyotype of bone marrow or peripheral blood cells was observed.

Adult↗
PubMed1986

Ir gene expression on T cells: effect of a monoclonal antibody directed against I region-controlled determinants on T cells.

A monoclonal antibody directed at an I region-controlled epitope uniquely expressed on T cells (Iat) was studied for its in vivo effect on the antibody response under the control of an Ir gene. The antibody was produced by a hybridoma made from A.TH spleen cells immune to A.TL (anti-Ik), that was selected for its reactivity with T but not B cells and macrophages, and thus was designated as anti-IatK. The injection of this anti-Iatk into H-2k, H-2b and H-2k X bF1 mice resulted in the suppression of antibody response to poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys [(H,G)-A--L] in H-2k and F1 mice but not that to poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys [(T,G)-A--L] both in H-2b and F1 mice. The adoptive cell transfer of the combinations of anti-Iatk- or normal mouse serum-treated T and B cells into irradiated hosts demonstrated that anti-Iatk primarily affected (H,G)-A--L-specific helper T cells but not B cells and macrophages, resulting in the specific elimination of the antibody response. Suppressor T cells were not induced by the treatment with anti-Iatk. The antibody specifically eliminated the (H,G)-A--L-specific but not (T,G)-A--L-specific helper T cells in F1 spleen cells that had been primed with both (H,G)-A--L and (T,G)-A--L. The results indicated that anti-Iatk affected the H-2k-associated Ir gene function born by T cells but not by antigen-presenting cells, which was expressed on F1 helper T cells with apparent exclusion of the other allele, and implied that the Iat antigen on helper T cells is one of the sites of expression of Ir genes.

Animals↗
PubMed1986

Protection of antiproliferative effect of cis-diamminedichloroplatinum (II) by sodium thiosulfate.

Utilizing the phytohemagglutinin (PHA) stimulation assay of human peripheral blood mononuclear cells (PBM), the protective effect of sodium thiosulfate (STS) on the antiproliferative action of cis-diamminedichloroplatinum (II) (DDP) against human cells was investigated. DDP alone significantly inhibited the proliferation of PBM over the concentration range of 10(-7) to 5 X 10(-5) M. The antiproliferative effect of DDP was significantly blocked when STS was added to the stimulation culture at the time of exposure to DDP at molar STS/DDP ratios of more than 500. However, STS at molar ratios of less than 100 induced minimal protection. Then, STS was added at various times after DDP exposure with a molar STS/DDP ratio of 1000. The protection was effective within 10 min after exposure to DDP at a concentration of 5 X 10(-5) M, whereas it was not effective beyond 30 min after the exposure. The results indicate that effective protection against DDP cytotoxicity in human cells can be achieved by the concurrent presence of STS with molar STS/DDP ratios of more than 500, but not when a molar STS/DDP ratio of less than 100 is used.

Cell Division↗
PubMed1986

Secretory carcinoma of the breast in a Japanese woman.

We report a case of secretory carcinoma of the breast in a 33 year old woman. Secretory carcinoma is a rare tumor and has distinctive pathological characteristics. This tumor usually occurs in children or adolescents. Modified radical mastectomy was carried out and the patient is doing well with no evidence of recurrence at 25 months later. Negative findings were obtained in the assay of estrogen and progesterone receptor.

Adult↗
PubMed1986

Involvement of eosinophils in leukemia: cytogenetic study of eosinophilic colonies from acute myelogenous leukemia associated with translocation (8;21).

We performed a cytogenetic analysis of eosinophilic colonies grown from bone marrow culture of a patient with acute myelogenous leukemia (FAB-M2) associated with t(8;21). The bone marrow, in which 50.2% myeloblasts and 5.6% eosinophils were observed, gave rise to eosinophilic colonies, as well as colonies consisting of immature myeloid cells. The cytogenetic analyses of the colonies were performed on two occasions. The first study revealed t(8;21) in 15 of 16 metaphases in randomly plucked colonies from a dish, in which 65% of the total colonies were those consisting of immature myeloid cells and 35% were eosinophilic colonies identified by positive staining with Luxol-Fast-Blue. The second study, in which eosinophilic colonies were selectively plucked for cytogenetic analysis, showed Cq- and Gq+ markers, which were considered to be t(8;21), in all metaphases (6/6). Our present study strongly suggests that an involvement of the eosinophilic series in the leukemic process of this patient.

Bone Marrow↗
PubMed1986

Expression of monocytic and T-lymphocytic phenotype in a variant form of acute promyelocytic leukaemia (M3).

A 46-yr-old woman was diagnosed as having M3 variant leukaemia in FAB subclassification with disseminated intravascular coagulation (DIC) and the 15;17 translocation. Immunologic examinations revealed that the blast cells exhibited monocytic (Ia+, Mo1+, Mo2+, My4+, My7+ and My9+) and T-lymphocytic (OKT11+, Leu4+ and Leu5b+) immunophenotype, with probably a biphenotypic population of cells. Expression of monocytic phenotype on the blast cells suggests that M3 variant includes a subtype with monocytic characteristics, and may be related to the morphologic monocyte-like feature of that of M3 variant.

Antibodies, Monoclonal↗
PubMed1986

[The effect of an arginine-imbalanced diet on the growth of implanted MM-48 and MH-134 tumors in C3H/He mice].

The arginine-imbalanced diet used in this study was a diet of 27% casein supplemented with 8% arginine monochloride. There was no difference in the serum protein level between C3H/He mice fed a casein diet (N-mice) and mice fed on the arginine-supplemented diet (A-mice). The serum arginine level was increased in the A-mice compared with the N-mice. Significant inhibition of MM-48 tumor incidence was seen in the A-mice when the transplanted tumor was below 5 X 10(6) cells. Growth inhibitory effect against MM-48 tumor was significantly enhanced in the A-mice with i.p. injection of OK-432. Interferon production of spleen cells was increased in the A-mice compared with the N-mice. We speculate that the effect of arginine depends partially on the immune functions in the mice.

Amino Acids↗
PubMed1986

[Randomized study of lentinan on patients with advanced gastric and colorectal cancer. Tohoku Lentinan Study Group].

A randomized study of mitomycin C (MMC)+5-FU [control group] vs MMC+5-FU+lentinan (LNT) [LNT group] was conducted in order to evaluate the effect of LNT against advanced gastric and colorectal cancers by the envelope method in 166 patients, comprising of 115 cases of gastric cancer and 51 cases of colorectal cancer. Significant increases were observed in the survival rates for the LNT group (p less than 0.05) for both patients with gastric and colorectal cancer. No significant difference was observed in response rates between the aforesaid two groups, though the response rate in the LNT group was slightly higher than the control group. These results suggest that LNT in combination with anticancer drugs prolong the survival time of patients with advanced gastric and colorectal cancer.

Adult↗