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Biomedical subjects

R Abe

Publications and source records attributed to R Abe.

At least 361 records · Page 20Linked to original sources
PubMed1987

Effect of low density lipoprotein on DNA synthesis of cultured human arterial smooth muscle cells.

Increased concentration of plasma low-density lipoprotein (LDL) is one of the risk factors in atherosclerosis. We studied how DNA synthesis of human arterial smooth muscle cells (SMC) was influenced in the culture added with or without small dose (25 micrograms of protein/ml) of LDL. LDL were ultracentrifugally obtained from normal subjects and diabetics. DNA synthesis was investigated at 6-h intervals during 36 h in the culture with or without LDL using [methyl-3H]thymidine. We found that DNA synthesis reached a maximum value at 24 h after addition of LDL. On the other hand sequential changes were not detectable in the culture without LDL addition. This effect of diabetic LDL was significantly (P less than 0.001) greater than that of normal LDL. These results suggested that LDL induces synchronization of the cultured SMC to synthesize DNA and diabetic LDL may play an atherogenic role more strongly than normal LDL in the arterial wall even in the normal range of LDL concentration.

Arteries↗
PubMed1987

Experience with Gleason histopathologic grading of prostatic cancer in Japan.

Histologic characteristics of prostate cancer in Japan were evaluated in a retrospective analysis of 267 cases. These specimens were graded by the Gleason histopathologic grading system, and the proportional distribution of histologic features and the death rate were compared with those of Gleason's results in the literature. The system demonstrates significant correlation with mortality rates for each grade group in our cases, and it was also found that the death rates as obtained by our figures were comparable to those of Gleason in each category. The results help to provide the basis for future comparative multinational trials of prostate cancer.

Adenocarcinoma↗
PubMed1987

Chromosome studies of hematopoietic colonies for distinct diagnosis of megakaryoblastic crisis of chronic myelogenous leukemia: a case report.

Chromosome studies of cells from megakaryocytic colonies (CFU-Meg) as evidenced by a megakaryocyte-specific monoclonal antibody, TP80, from a patient with chronic myelogenous leukemia (CML) in the blast crisis (BC) revealed the same aberrant karyotype, 52,XY,+9,+9,+18,+19,+21,+22,t(9;22)(q34;q11),t(9;22), as that having newly appeared in the peripheral blood. Cells from erythroid bursts (BFU-E) showed only the standard 46,XY,t(9;22) karyotype, and cells from granulocyte/macrophage colonies (CFU-GM) had either of these karyotypes. These results demonstrated that the whole megakaryocytic line and part of the granulocyte/macrophage line had been involved in the BC while the erythroid line totally belonged to the original clone. Chromosome analysis coupled with immunophenotyping of hemopoietic colonies was useful for a definite diagnosis of megakaryoblastic crisis of CML in this patient.

Adult↗
PubMed1987

A case of acute myelogenous leukaemia associated with eosinophilia: cytogenetic study of eosinophilic colonies showing the origin of the normal clone.

We describe a case of acute myelogenous leukaemia presenting with remarkable eosinophilia in relapse. Since the patient had chromosomal abnormalities, haemopoietic as well as eosinophilic colonies grown in culture were cytogenetically analysed to determine the origin of the eosinophils. Eosinophilic colonies as well as erythroid bursts revealed a normal karyotype, while a short-term culture of peripheral blood cells in relapse revealed an abnormal karyotype which had been observed before treatment. These data clearly demonstrate that the eosinophilia in this case originated from a normal clone. The cytogenetic analysis of eosinophilic colonies is a useful technique for the definite diagnosis of eosinophilic leukaemia or reactive eosinophilia in patients having marker chromosomes.

Adult↗
PubMed1987

[Treatment of renal cell carcinoma invading the inferior vena cava; role of preoperative targeting chemotherapy].

Locally invasive carcinoma of the kidney, prognosis of which still remains unsatisfactory, is a therapeutic challenge in uro-oncology. Our recent experience has indicated that mitomycin C microcapsule therapy which is introduced as a prototype of intravascular targeting chemotherapy is an effective preoperative adjuvant in terms of improving the prognosis of locally invasive kidney carcinoma. Two cases with huge kidney carcinoma directly invading into the caval wall were presented. They were initially considered inoperable, but repeated microcapsule therapy for 5 months provided substantial tumor reduction and facilitated radical operation. The patients are tumor-free at 2 and 8 year after the treatment respectively. The role of targeting chemotherapy in the treatment of locally invasive carcinoma was discussed.

Adult↗
PubMed1987

[Multihospital randomized study on adjuvant chemotherapy with mitomycin C and futraful or UFT in gastric cancer (Part 1). Comparison between futraful and UFT. North Kyushu Co-operative Study Group for Cancer Chemotherapy)].

The present study was undertaken to evaluate the effect of postoperative adjuvant chemotherapy for 232 cases of gastric cancer by a co-operative study group consisting of 21 hospitals. The present paper describes the side effects and the 2-year survival rates in patients. Side effects observed during long-term treatment with Futraful or UFT were considered to be minor, although incidence of toxicity in the UFT group was slightly higher than in the Futraful group. As for 2-year survival, elevated survival was found in stage III cases of poorly differentiated adenocarcinoma. This suggested that UFT is more useful than Futraful.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Experimental studies on the enhanced effects of chemoendocrine therapy in breast cancer].

The clinical response rate of chemotherapy or endocrine therapy for advanced or recurrent breast cancer has been described as being about 30%, regardless of steroid hormone status. However, the response rate for endocrine therapy is about double in patients with positive estrogen receptor. In order to obtain a higher response rate than that for single therapy, experimental attempts were made to combine cytotoxic agents, antiestrogenic agents, ablative therapy and immunotherapy from the viewpoints of tumor cell kinetics, natural killer activity and interferon activity of spleen cells. Tamoxifen and orchiectomy were shown by flow cytometry to produce a G1 block, increasing the G0, G1 phase and decreasing the S phase, in MCF-7 cells in vitro and in SC 115 cells, in vivo respectively, for a long period. On the other hand, 5-FU showed most effective cytotoxicity in the S phase of both types of tumor cells in vitro and in vivo, although the depressed S phase recovered within 24 hours. Therefore, any combined chemo-endocrine therapy should be devised so that the endocrine therapy maintains a G1 block for a long period and performed immediately following chemotherapy during the decreased S phase of the tumor cells. N K activity of spleen cells were enhanced, and interferon production in spleen cells was not changed by ovariectomy in C3H/He mice compared with sham-operated mice. It is suggested that endocrine therapy may affect the immunopotentiality of cancer patients.

Animals↗
PubMed1987

Trial of early detection for breast cancer by itinerant mass screening.

Since 1977 mass screening for breast cancer has been conducted in Miyagi Prefecture, Japan. The main activities involve itinerant screening in the communities and group screening at the workplaces. In addition to the above two screenings, examinations were also carried out at a Detection Center. The total number of examinees was 94,593. Breast cancer was detected in 116 subjects (0.12%) during mass screening. In contrast, the rate was 3.1% at the Center examination. Early cancer was more frequently detected during mass screening. The cytologic studies of nipple discharge was performed in 14,314 subjects (15.3%). Positive findings were seen in five (0.005%). In the high risk group, the detection rate (0.35%) was higher than that (0.12%) among general examinees. The higher detection rate in the high risk group may have been due to both the high frequency of breast cancer and the detection of nonpalpable breast cancer by mammography.

Breast Neoplasms↗
PubMed1987

[The breast cancer-prone family: clinical study of familial breast cancer].

Familial breast cancer are clinically characterized by early age of onset, the increased frequency of multiple primary malignant neoplasms including bilateral breast cancer and non-left-side dominance with regard to the site of onset. The genetic consideration of the pedigrees suggests that familial clustering of breast cancer is related to the autosomal dominance of susceptibility, polygenes and incomplete penetrance. The additive effects obtained by combining the genetic with the environmental factors are recognized in familial breast cancer. Clinical surveys and follow-ups of breast-cancer-prone families are required to facilitate the early detection and treatment.

Adult↗
PubMed1987

[The analgesic effect of calcitonin on breast cancer patients with bone metastases].

Lately it has been reported that calcitonin is effective for the treatment of hypercalcemia and for the relief of pain caused by osteolytic bone metastasis. Thus we have studied the analgesic effect of synthetic eel calcitonin (ECT) on 8 breast cancer patients with bone metastases. ECT was administered in the dose of 20 or 40 I.U. twice a day intramuscularly for 7 days without other antineoplastic treatment, and the laboratory data of its analgesic effect and change has been examined. An analgesic effect was obtained on all 8 patients who had received ECT. However, an improvement of radiological findings of metastatic osteolysis and a decrease in urine hydroxyproline were not found after short term (7 days) treatment with calcitonin. These results suggest that the effect of ECT on the relief from pain due to bone metastasis is not caused by an improvement of the osteolytic metastatic lesions.

Adult↗