Search PubMed⌕ Search

Biomedical subjects

Q Debray

Publications and source records attributed to Q Debray.

At least 37 records · Page 2Linked to original sources
PubMed1980

Schizophrenia: the testing of genetic models by pedigree analysis.

Simulated pedigrees of schizophrenia generally show a clear peak in their likelihood surface corresponding to analysis by the genetic models, which served as the basis for the simulation. The likelihood surface obtained with real data permits determination of the allelic frequency and the selection of an optimal one-locus, two-locus, and four-locus model. These three models have certain features in common, notably, a relatively high frequency of the allele predisposing to schizophrenia (about 20%) and a relatively low index of genetic determination (23%--34%). However, direct likelihood comparisons do not permit distinctions between the one-locus, two-locus, and four-locus models. The most likely interpretation of this finding is that the etiology of schizophrenia is heterogeneous or even nongenetic. However, a simple model with a single completely recessive locus and incomplete penetrance in the homozygote also produces a flat likelihood surface closely resembling that obtained with the real data. With reservation, this single-locus model may be put forward as a potentially useful working hypothesis.

Alleles↗
PubMed1979

Schizophrenia: a study of genetic models.

The likelihoods of observing 25 four-generational families of schizophrenics comprising 1,333 individuals have been calculated on the basis of 12 different genetic models and one control 'sporadic' model. The control model gave a log10 likelihood (L), of -240.92. Five of the genetic models were definitely excluded as incompatible with certain pedigrees. The three models with the highest likelihoods were: one locus, the heterozygote having a 10% probability of being classified schizophrenic (L: -220.05); two interacting loci (L:-219.46); and four polygenes (L:-216.87).

Alleles↗
PubMed1978

Schizophrenia: a study of genetic models and some of their implications.

The likelihoods of observing 25 four-generational families of schizophrenics comprising 1,333 individuals have been calculated on the basis of 12 different genetic models and one control 'sporadic' model. The control model gave a log10 likelihood, L, of -240.92. Five of the genetic models were definitely exlcuded as incompatible with certain pedigrees. The three models with the highest likelihoods were: one locus, the heterozygote having a 10% probability of being classified schizophrenic (L: - 220.05); two interacting loci (L: -219.46), and four polygenes (L: -216.87).

Alleles↗
PubMed1978

[Nondiscal sciatica without organic lesion].

Among 1 800 patients operated on for hernia of the disc, 2% were completely negative on surgical exploration. Since a psychiatric aetiology might be involved, these patients were again given physical examination, clinical psychiatric examination and a personality test (minimult). This psychometric examination yelded pathological results in 68% of these patients. A comparison with two control groups operated on for hernia of the disc permitted a distinction of statistically significant differences. The results are compared with similar studies by other authors on patients with lumbalgia and dorsalgia. A practical approach is defined.

Adult↗
PubMed1975

A genetic study of chronic delusions.

There is a nosologic difference between the French schizophrenia and the English schizophrenia which include all chronic delusions. A genetic study of chronic delusions, based on the rules of the French nosology, has two goals: two clarify their genetic etiology, and to test those nosologic differences. This study was made on the families of 45 patients with chronic delusions. The conclusions are: the 'délires paranoïaques chroniques' have a genetic etiology and are related to schizophrenia; the 'psychoses hallucinatoires chroniques' are not influenced by the genetic etiology and are not related to schizophrenia. Therefore, the psychoses hallucinatoires chroniques' constitute an autonomic entity according to the French nosology.

Adult↗