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Biomedical subjects

P Schuster

Publications and source records attributed to P Schuster.

At least 145 records · Page 8Linked to original sources
PubMed1977

[Orally-administered taurine in therapy-resistant epilepsy (author's transl)].

The anticonvulsive action of taurine, was tested in 9 therapy in 9 therapy-resistant patients with a high incidence of seizures. Taurine was given orally (1.5-7.5 g daily) over a period of 4 to 16 weeks and, despite the high dosage, no appreciable side effects were observed. During this time seizures disappeared temporarily for about two weeks in 5 out of 9 cases. In one case the seizure frequency was transiently reduced by approximately 25%, whilst in the remaining 3 cases no effect of taurine on seizure frequency was observed. The reason for the rapid disappearance of the anticonvulsive action of taurine is not known.

Administration, Oral↗
PubMed1977

Reversal by physostigmine of clozapine-induced delirium.

Clozapine, a new antipsychotic drug without extrapyramidal side effects and with strong sedating potency, can produce acute symptoms of central anticholinergic toxicity. The authors report that physostigmine, a reversible anticholinesterase agent, which can pass the blood-brain barrier, was effective in reversing the clozapine-induced brain syndrome in two patients. Physostigmine also reduced one patient's tachycardia.

Adult↗
PubMed1977

[Changes of heart rate in relation to diurnal variations in endogenic depression in women].

Heart rate data as produced by the subjects under investigation both in resting conditions and taken as total means per trial initially showed a trend towards ergotropic, clearly tachycardiac behavior; with the onset of thymoleptic drug therapy, there followed a further increase in heart rate, frequencies remaining more or less stationary on this level during the 26-day period observed by us. We found differences between morning and evening data of session A with 50% of subjects, 25% showing higher frequencies in their morning data, the reverse applying to a further 25%. The remaining 50% did not show any differences worth mentioning. At the end of the investigation period, the relation changed in favor of an increase in heart rate in the evening with 50% of subjects, whereas only 12.5% showed increased heart rate in the morning; 37.5% did not show significant differences. We could not demonstrate these results to be related to diurnal variation, degree of depression or course of the disease.

Circadian Rhythm↗
PubMed1977

[Relations between subjective-psychological, physiological and behavioral levels in endogenous depressions].

In a longitudinal study of depressed episodes, changes in patients' state were examined by variables on the subjective-psychological, physiological and behavioral levels, respectively. Starting from the hypothesis of a systematic connection of these variables changes in patients' condition were defined from merely one of the above-mentioned levels, i.e. the test-psychological criteria relating to the subjective-psychological level ('Polaritätsprofil'). Results based on the rank analysis of covariance are presented which show the complex multivariate correlations between the three levels.

Analysis of Variance↗
PubMed1976

[Individual conditions of pharmacogenic confusion conditions. Comparison of amitriptyline and clozapine].

The literature was surveyed concerning the frequency and conditions for confusional states and deliria following Amitriptyline and Clozapine treatment, and certain discrepancies were noted. As a result a retrospective comparative investigation was carried out as to the frequency and the conditions for such events in a group of patients treated along the same lines. While our experience with Amitriptyline is not different from that reported by others, this does not seem to be the case with Clozapine. Confusional states and deliria are four times as frequent as the average reported in the literature; it is clear that they depend on conditions different from those of confusional states and deliria due to Amitriptyline; there is a slightly significant (p less than 0.05) correlation between the appearance of confusion and a temperature of over 37.5 degrees C. The anticholinergic properties of Amitriptyline and of Clozapine cannot explain the difference in frequency, nor the differing conditions for the appearance, of pharmacogenic confusional states and deliria with those two substances.

Adult↗
PubMed1976

Effect of bromazepam on gastric acid secretion related to hypnotically induced anxiety.

The effects of bromazepam (0.1 mg/kg b.w. i.v.) and of placebo on gastric acid secretion related to hypnotically induced anxiety were evaluated in a double blind study, 22 experiments were carried out on 4 healthy volunteers. Drugs were injected after one basal hour. Hypnosis was induced immediately thereafter, and a sequence of anxiety-charged situations out of the subjects past was recalled. After one hour, posthypnotic amnesia was suggested, the subjects awakened and observation continued for another hour. Acid output was measured by means of intragastric titration and a telemetering capsule. During hypnosis and recalling of anxiety in both series, acid output decreased. In the posthypnotic hour there was a significant increase of secretion in the placebo-series, while there was virtually no change in the the bromazepam-series. The pattern of acid output in the placebo-series seems to result from an activation of the sympathetic system under anxiety and a rebound vagal activation in the posthypnotic hour. By contrast, under the sedating effect of bromazepam, no anxiety could be evoked and no rebound vagal activation and thereby no increase of acid secretion resulted.

Adult↗