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Biomedical subjects

P Rasmussen

Publications and source records attributed to P Rasmussen.

At least 37 records · Page 2Linked to original sources
PubMed1997

Gender identity disorder in a girl with autism--a case report.

A girl with high functioning autism who developed transsexualism is described. The literature to date has, to the authors' knowledge, not documented any similar case. The diagnosis of a coexisting psychiatric disorder in transsexualism has implications for the evaluation, prognosis, and appropriate management of the patient. The question of a possible relationship between autism and transsexualism and whether there is a predisposition to gender dysphoria in autism, is discussed.

Adolescent↗
PubMed1997

Melatonin cycle in the fiddler crab Uca pugilator and influence of melatonin on limb regeneration.

Melatonin was measured over 24 hr in the eyestalks of Uca pugilator by means of radioimmunoassay; crabs were acclimatized either to a LD 12:12 photoperiod or constant darkness. A significant peak occurred at 13.00 hr in the LD 12:12 crabs. A photophase peak in melatonin has only been reported in one other species, also a crustacean. In constant darkness, two melatonin peaks occurred, one at 16.00 hr and the other 12 hr later; these results suggest that the melatonin cycle is a true circadian rhythm. HPLC with ultraviolet-visible detection was used to confirm the identity of melatonin immunoactivity. The influence of melatonin on regeneration of the walking legs was also examined: eyestalks were either removed or left intact, and limb bud length was measured every other day for at least 17 days in control and melatonin-treated crabs (60 microg ml(-1) seawater). Melatonin significantly increased the rate of limb regeneration in both eyestalk-intact and eyestalk-removed groups; this is contrary to results of regeneration studies in other phyla, in which similar melatonin concentrations inhibited regeneration.

Animals↗
PubMed1997

Inherited retarded eruption in the permanent dentition.

The term retarded eruption, may be used in cases where eruption is inhibited, causing an interruption in the coordination of tooth formation and tooth eruption. The phenomenon may be local or general, and several etiological factors for retarded eruption have been listed, comprising a lack of space, ankylosis, cysts, supernumerary teeth, hormone and vitamin deficiencies and several developmental disturbances and syndromes. The present paper describes several cases of retarded eruption where no factors other than inheritance have been evident. So far 14 cases have been evaluated, 9 boys and 5 girls. In addition several cases have been registered among parents and grandparents of the probands. Typical features are: retarded eruption, defined as more than 3 SD beyond mean eruption figures, comprises all teeth in the permanent dentition, and in 5 cases also second primary molars. The chronology of tooth formation are within normal limits. Consequently the teeth finish development still laying deeply buried in the jaws, often in aberrant positions and with curves or hooks on the roots. When the teeth finally get the "signal" for eruption, 5-15 years beyond normal eruption time, they move rather quickly into right positions, despite the long eruption paths and the hooked roots. Permanent teeth without, as well as with predecessors, are affected. Extraction of predecessors does not seem to provoke eruption. The main features in management are to take care of the primary teeth, to improve-esthetics, and offer surgery and orthodontics when needed. Analyses of pedigrees indicates that the genetic transmittance may be autosomal dominant as both sexes are affected, about half of the siblings show the trait, and the trait shows continuity through generations.

Adolescent↗
PubMed1996

Transient psychosis in a girl with epilepsy and continuous spikes and waves during slow sleep (CSWS).

A normally developed and healthy 6-year-old girl suffered the onset of epilepsy with generalized tonic-clonic seizures and atypical absences. Initially the EEG showed epileptiform activity over the temporal and parietal regions, later there were episodes of bilateral synchronous spike-wave activity with a frequency of 1.5-2.5 Hz. After a few months, deterioration of cognitive and behavioural functions appeared and gradually increased with the development of a full-blown disintegrative psychosis that went on for several months. Sleep EEG recordings showed the characteristic abnormality described as continuous spikes and waves during slow sleep. Later there was a remarkable improvement of neuropsychiatric functions but a second outbreak of psychosis seems to have left the girl, who is now 9 years of age, with severe mental impairment.

Age of Onset↗
PubMed1996

Detection of endogenous beta-glucuronidase activity in Aspergillus niger.

An endogenous beta-glucuronidase that hydrolyses the chromogenic substrate 5-bromo-4-chloro-3-indolyl-beta-D-glucuronide (X-gluc) in Aspergillus niger is reported. The activity was induced when the fungus was grown in media containing xylan, but was either very low, or absent, when grown on glucose. Endogenous beta-glucuronidase was primarily located in newly formed hyphae, and was apparent at pH values between 3 and 6. Hydrolysis of X-gluc was sensitive to the inhibitor D-saccharic acid 1,4-lactone and was irreversibly inactivated by heating. The bacterial uid A beta-glucuronidase reporter gene was strongly expressed in the hyphae of transformed A. niger but, in contrast to the endogenous activity, the enzyme was also active at pH 7-8.5. Histochemical localization of uidA expression in A. niger, without interference from the endogenous beta-glucuronidase activity, was achieved by staining at this pH.

Aspergillus niger↗
PubMed1996

The congenital insensitivity-to-pain syndrome (analgesia congenita): report of a case.

The congenital insensitivity-to-pain syndrome is one of several entities of sensory neuropathies in which pain sensation is absent from birth. This report describes a female child with the syndrome, who in all other aspects was normal. The most severe oral consequence of her disorder was self-inflicted exfoliation at an early age of all single-rooted primary teeth and one primary molar (a total of 13 teeth). The child was monitored from age 8. The primary aim in management was to monitor the eruption of the permanent teeth and occlusal development. At eruption of the mandibular incisors a protective splint was constructed to prevent their sharp edges injuring the tongue and the oral mucosa. The child was also instructed not to agitate her newly erupted teeth. Further occlusal development of the permanent dentition was uneventful.

Child↗
PubMed1994

[Who counsels young people on contraception?].

In October 1989 a representative sample consisting of 359 women (response rate = 77.9%) and 400 women (response rate = 76.3%) aged 16-20-years old was interviewed by the professional interviewer staff of the Institute for Social Research. The purpose of the investigation was to illustrate whether AIDS and "Safe sex"-campaigns have influenced young people. This paper deals with data about contraceptive counselling. The majority (284 (79.1%) among women and 270 (67.5%) among men) would attend the general practitioner for contraceptive guidance. The public Contraceptive Guidance Clinics are considered an alternative source of service. In all, 38.2% of females and 29.3% of males knew of the existence of a clinic. This knowledge was not associated with age or education of the respondent. Among men information about the clinic was associated with sexual experience. Schools appear to be an effective channel of information. In the county of Ribe more than 80% among both sexes knew th public clinic.

Adolescent↗
PubMed1993

The prevalence of caries in groups of children aged 4-5 and 7-8 years in Khartoum, Sudan.

A total of 544 children, 275 pre-school children (aged 4-5 years) and 269 school children (aged 7-8 years), were examined for dental caries using WHO criteria with some modifications. The children were resident in Khartoum, Sudan. The mean dmft was 1.68 in the 4-5-year group, and 58% of them were caries-free. In the 7-8-year group the mean dmft (molars and canines) was 2.77, and 33% of the children were caries-free. Most of the caries in both groups was untreated. In decayed teeth which were not beyond repair, occlusal caries was most prevalent in the pre-school group and approximal caries most prevalent in the school group. The mean DMFT in the 7-8-year group was 0.15, and only occlusal surfaces in first molars were affected. Ninety-four percent in the 7-year group and 88% in the 8-year group were caries-free in the permanent dentition. When the children were grouped according to their socio-economic level, there were no statistically significant differences in caries prevalence between the groups. Since this is the first comprehensive caries prevalence study of these age groups in Sudan, it is impossible to conclude whether caries is increasing or not. The prevalence of caries-free preschool children is above the global goal of FDI/WHO for the year 2000, but below the goal for developing countries.

Age Factors↗
PubMed1993

Persistent mirror movements: a clinical study of 17 children, adolescents and young adults.

The author reports a series of 17 cases of congenital mirror movements of the hands and forearms (and in a few cases the toes), but no other signs of gross neurological deviation. This is an uncommon disorder that often goes unrecognised. This slight but definite disability seems to persist largely unchanged at least into the late teens, and probably into adulthood. A hereditary background is suggested in about half of the cases. Various neuropsychiatric deficits were seen in combination with the mirror movements in about half the cases, as well as a high incidence of non-right-handedness. Although the clinical heterogeneity of the disorder was clear, the phenomenon of mirror movements was similar in all cases. Recent progress in understanding the pathophysiology of this disorder is reviewed.

Adolescent↗
PubMed1992

[Pseudomonas infection associated with whirlpool bath].

After using a whirlpool-spa when the chlorine concentration in the water was very low (0.1 mg/l free chlorine) approximately 20 persons developed a follicular rash. No cases were registered in bathers when the chlorine concentration was acceptable (0.9-1.2 mg/l). The same sero-group and phagetype of Pseudomonas aeruginosa was cultivated from a patient and from the piping system of the spa. The importance of following directions for the installation of whirlpool-spas and regulations for their operation and control is strictly stressed. The National Agency for Environmental Protection is asked to reinforce the existing regulations concerning whirlpool-spas.

Adult↗
PubMed1992

Synthesis and collagenase inhibition of new glycosides of aranciamycinone: the aglycon of the naturally occurring antibiotic aranciamycin.

Glycosides of aranciamycinone were prepared by glycosylation with sugar acetates and trimethylsilyl triflate in dichloromethane. Glycosides of the following sugars were prepared: alpha-L-rhamnopyranose, beta-D-glucopyranose, beta-D-ribopyranose, beta-D-xylopyranose, alpha-L-fucopyranose, 2-azido-2,6-dideoxy-alpha-L-mannopyranose, 2,6-dideoxy-alpha-L-arabino-hexopyranose, 3,6-dideoxy-alpha-L-arabino-hexopyranose, and 4,6-dideoxy-alpha-L-lyxo-hexopyranose. The new glycosides were tested for inhibition of Clostridium histolyticum collagenase and Yoshida Sarcoma tumor cells.

Animals↗
PubMed1992

Inhibition of collagenase by aranciamycin and aranciamycin derivatives.

Aranciamycin (1), an anthracycline antibiotic, was found to be an inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10(-7) M. Elastase and trypsin were not inhibited at concentrations less than or equal to 10(-5) M. A number of aranciamycin derivatives 2-13 were prepared and tested for collagenase inhibition. While loss of activity was found for derivatives modified in the sugar ring or rings B and D of the aglycone, increased potency was found when the tertiary alcohol at C-9 was esterified. All compounds 1-13 were found to inhibit DNA synthesis of Yoshida sarcoma tumor cells.

Animals↗
PubMed1992

Enamel defects in primary canines related to traditional treatment of teething problems in Sudan.

In parts of Sudan and some other countries, teething is thought to be the cause of severe health problems in infants, and a traditional treatment involves lancing the alveolar process over the unerupted canines with a heated needle, a procedure known as 'haifat'. Three hundred and ninety-eight children aged 4-8 years were examined for the presence of enamel defects on primary canines, and their parents or guardians were questioned regarding past teething problems and their treatment. Two hundred and fifty-eight (65%) of the children had experienced health problems that had been attributed to teething, and 89 (22%) had been subjected to 'haifat'. 'Haifat' had been practised by all socio-economic groups, but was most prevalent in the lower groups. Enamel defects on the buccal surface of the primary canines were found in 25 (28%) of the children in the 'haifat' group and in 25 (8%) of the other children.

Chi-Square Distribution↗
PubMed1991

Facial pain. III. A prospective study of the localization of facial pain in 1052 patients.

The study is based on 1052 prospective patients. They have been divided into 3 groups according to the duration of the attack. The purpose of this study is to evaluate the importance of localization of the pain in order to determine its patho-anatomical basis. The right/left ratio was 2/1 in the Neuralgia Patients. There was no difference in patients with Non-neuralgiform Pain. There were extremely few cases of bilateral pain among the Neuralgia Patients, 15% among patients with Non-neuralgiform Pain. In the Neuralgia Patients there was a predominantly deep localization up to 50%, the Non-neuralgiform Pain 74%. Seventeen points of origin of pain have been registered in the face. By far the most frequent is a point of origin with radiation. If the percentage distribution is calculated according to each trigeminal division, the point of origin of pain in 74% is the eyebrow in the area of the 1st division, as regards the 2nd and 3rd divisions more than 30% from the upper gingiva, the area in front of the ear and the lower gingiva and between 11 and 20% from the forehead and the hairline, the upper lip and the nasolabial sulcus, the maxilla and the cheek. Pain radiation is generally most frequent to the division from which the pain originates. Neuralgia hardly radiates outside the boundaries of the face. The pain is localized within the area of one division in 42%. The radiation is not systematic. It is not possible from the localization of the pain to decide any patho-anatomical basis of the pain. Nothing in the localization of pain can be used for classification of facial pain (particularly not the "parallelism" or the "peripheral course').

Brain Diseases↗
PubMed1991

Facial pain. IV. A prospective study of 1052 patients with a view of: precipitating factors, associated symptoms, objective psychiatric and neurological symptoms.

In a prospective material of 1052 patients the precipitating factors, associated symptoms, psychological and neurological deficits have been examined. Mastication and talking are the most frequently occurring precipitating factors, 76% as regards Neuralgia, with typical starting difficulties. As regards Non-neuralgiform Pain 24%, with precipitation late in the masticatory process. There were trigger zones in 50% of the cases of Typical Trigeminal Neuralgia and in 9% of the patients with Non-neuralgiform Pain. In a series of cases the jaw joint is perceived as a trigger zone. Cold precipitates pain in 48%-39%. Other precipitating factors are much more rare--psychological stress in 15% of the patients with Non-neuralgiform Pain, however. "Vegetative" associated symptoms were relatively frequent, lacrimation occurred in 31% of the cases of Typical Trigeminal Neuralgia and in 20% of the cases of Non-neuralgiform Pain. Rhinorrhea and salivation were less frequent. In terms of figures migrainoid associated symptoms had no connection with vegetative associated symptoms or with pain in the eye. In 11% of the patients pain occurred most frequently during the night and in 20% the frequency of pain was the same day and night. About 1/3 of the patients with Neuralgia experienced seasonal variations. Tenderness of foramina is a symptom of no significance. Very few patients had primary sensory loss. No eye or ear symptoms have been found which may be referred to as the patho-anatomical basis of the pain. About 1/3 of the patients with Non-neuralgiform Pain had psychological symptoms whereas hardly any patients with Neuralgia had them. MMPI test performed on a small matched material showed no difference between Neuralgia and Non-neuralgiform Pain. In material B an examination has been made of the jaw joint arthrosis symptoms. A restriction of the diagnosis of arthrosis has had the effect that it must be recognized that patients with facial pain do not have the high frequency of jaw joint diseases previously assumed. As was also the case in a series of normal material previously published, between 1, 5 and 1, 3 of the patients with Neuralgia had jaw joint arthrosis which was due to old age. This study has not revealed any connection between previous diseases, the onset of pain, the character and course of the pain, the character of the attack, the localization of pain, precipitating factors, associated symptoms and symptoms of loss on the one hand and the patho-anatomical substratum on the other.

Arousal↗