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Biomedical subjects

P Rasmussen

Publications and source records attributed to P Rasmussen.

At least 19 recordsLinked to original sources
PubMed1992

[Pseudomonas infection associated with whirlpool bath].

After using a whirlpool-spa when the chlorine concentration in the water was very low (0.1 mg/l free chlorine) approximately 20 persons developed a follicular rash. No cases were registered in bathers when the chlorine concentration was acceptable (0.9-1.2 mg/l). The same sero-group and phagetype of Pseudomonas aeruginosa was cultivated from a patient and from the piping system of the spa. The importance of following directions for the installation of whirlpool-spas and regulations for their operation and control is strictly stressed. The National Agency for Environmental Protection is asked to reinforce the existing regulations concerning whirlpool-spas.

Adult↗
PubMed1992

Synthesis and collagenase inhibition of new glycosides of aranciamycinone: the aglycon of the naturally occurring antibiotic aranciamycin.

Glycosides of aranciamycinone were prepared by glycosylation with sugar acetates and trimethylsilyl triflate in dichloromethane. Glycosides of the following sugars were prepared: alpha-L-rhamnopyranose, beta-D-glucopyranose, beta-D-ribopyranose, beta-D-xylopyranose, alpha-L-fucopyranose, 2-azido-2,6-dideoxy-alpha-L-mannopyranose, 2,6-dideoxy-alpha-L-arabino-hexopyranose, 3,6-dideoxy-alpha-L-arabino-hexopyranose, and 4,6-dideoxy-alpha-L-lyxo-hexopyranose. The new glycosides were tested for inhibition of Clostridium histolyticum collagenase and Yoshida Sarcoma tumor cells.

Animals↗
PubMed1992

Inhibition of collagenase by aranciamycin and aranciamycin derivatives.

Aranciamycin (1), an anthracycline antibiotic, was found to be an inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10(-7) M. Elastase and trypsin were not inhibited at concentrations less than or equal to 10(-5) M. A number of aranciamycin derivatives 2-13 were prepared and tested for collagenase inhibition. While loss of activity was found for derivatives modified in the sugar ring or rings B and D of the aglycone, increased potency was found when the tertiary alcohol at C-9 was esterified. All compounds 1-13 were found to inhibit DNA synthesis of Yoshida sarcoma tumor cells.

Animals↗
PubMed1992

Enamel defects in primary canines related to traditional treatment of teething problems in Sudan.

In parts of Sudan and some other countries, teething is thought to be the cause of severe health problems in infants, and a traditional treatment involves lancing the alveolar process over the unerupted canines with a heated needle, a procedure known as 'haifat'. Three hundred and ninety-eight children aged 4-8 years were examined for the presence of enamel defects on primary canines, and their parents or guardians were questioned regarding past teething problems and their treatment. Two hundred and fifty-eight (65%) of the children had experienced health problems that had been attributed to teething, and 89 (22%) had been subjected to 'haifat'. 'Haifat' had been practised by all socio-economic groups, but was most prevalent in the lower groups. Enamel defects on the buccal surface of the primary canines were found in 25 (28%) of the children in the 'haifat' group and in 25 (8%) of the other children.

Chi-Square Distribution↗
PubMed1991

Facial pain. III. A prospective study of the localization of facial pain in 1052 patients.

The study is based on 1052 prospective patients. They have been divided into 3 groups according to the duration of the attack. The purpose of this study is to evaluate the importance of localization of the pain in order to determine its patho-anatomical basis. The right/left ratio was 2/1 in the Neuralgia Patients. There was no difference in patients with Non-neuralgiform Pain. There were extremely few cases of bilateral pain among the Neuralgia Patients, 15% among patients with Non-neuralgiform Pain. In the Neuralgia Patients there was a predominantly deep localization up to 50%, the Non-neuralgiform Pain 74%. Seventeen points of origin of pain have been registered in the face. By far the most frequent is a point of origin with radiation. If the percentage distribution is calculated according to each trigeminal division, the point of origin of pain in 74% is the eyebrow in the area of the 1st division, as regards the 2nd and 3rd divisions more than 30% from the upper gingiva, the area in front of the ear and the lower gingiva and between 11 and 20% from the forehead and the hairline, the upper lip and the nasolabial sulcus, the maxilla and the cheek. Pain radiation is generally most frequent to the division from which the pain originates. Neuralgia hardly radiates outside the boundaries of the face. The pain is localized within the area of one division in 42%. The radiation is not systematic. It is not possible from the localization of the pain to decide any patho-anatomical basis of the pain. Nothing in the localization of pain can be used for classification of facial pain (particularly not the "parallelism" or the "peripheral course').

Brain Diseases↗
PubMed1991

Facial pain. IV. A prospective study of 1052 patients with a view of: precipitating factors, associated symptoms, objective psychiatric and neurological symptoms.

In a prospective material of 1052 patients the precipitating factors, associated symptoms, psychological and neurological deficits have been examined. Mastication and talking are the most frequently occurring precipitating factors, 76% as regards Neuralgia, with typical starting difficulties. As regards Non-neuralgiform Pain 24%, with precipitation late in the masticatory process. There were trigger zones in 50% of the cases of Typical Trigeminal Neuralgia and in 9% of the patients with Non-neuralgiform Pain. In a series of cases the jaw joint is perceived as a trigger zone. Cold precipitates pain in 48%-39%. Other precipitating factors are much more rare--psychological stress in 15% of the patients with Non-neuralgiform Pain, however. "Vegetative" associated symptoms were relatively frequent, lacrimation occurred in 31% of the cases of Typical Trigeminal Neuralgia and in 20% of the cases of Non-neuralgiform Pain. Rhinorrhea and salivation were less frequent. In terms of figures migrainoid associated symptoms had no connection with vegetative associated symptoms or with pain in the eye. In 11% of the patients pain occurred most frequently during the night and in 20% the frequency of pain was the same day and night. About 1/3 of the patients with Neuralgia experienced seasonal variations. Tenderness of foramina is a symptom of no significance. Very few patients had primary sensory loss. No eye or ear symptoms have been found which may be referred to as the patho-anatomical basis of the pain. About 1/3 of the patients with Non-neuralgiform Pain had psychological symptoms whereas hardly any patients with Neuralgia had them. MMPI test performed on a small matched material showed no difference between Neuralgia and Non-neuralgiform Pain. In material B an examination has been made of the jaw joint arthrosis symptoms. A restriction of the diagnosis of arthrosis has had the effect that it must be recognized that patients with facial pain do not have the high frequency of jaw joint diseases previously assumed. As was also the case in a series of normal material previously published, between 1, 5 and 1, 3 of the patients with Neuralgia had jaw joint arthrosis which was due to old age. This study has not revealed any connection between previous diseases, the onset of pain, the character and course of the pain, the character of the attack, the localization of pain, precipitating factors, associated symptoms and symptoms of loss on the one hand and the patho-anatomical substratum on the other.

Arousal↗
PubMed1990

Facial pain. I. A prospective survey of 1052 patients with a view of: definition, delimitation, classification, general data, genetic factors, and previous diseases.

1052 patients with facial pain have been examined and followed up by the author for an 18-year period. The patients are classified according to type of attack into: Typical Trigeminal Neuralgia (brief pain paroxysms with pain-free intervals). Atypical Trigeminal Neuralgia (pain paroxysms with intervals of pain or paroxysms lasting for minutes). Non-neuralgiform Facial Pain (pain lasting or occurring for long periods). The material was equally distributed between patients with Neuralgia and Non-neuralgiform Facial Pain. In the majority of cases Trigeminal Neuralgia occurred after the age of 50. Non-neuralgiform Pain mainly between 30 and 50. There is a majority of women with Non-neuralgiform Pain. No genetic factors could be demonstrated. A detailed registration of previous diseases in the central nervous system, the peripheral nerves, and the facial structures revealed no relation to important aetiological factors.

Adult↗
PubMed1990

Facial pain. II. A prospective survey of 1052 patients with a view of: character of the attacks, onset, course, and character of pain.

The material, definition, delimitation, and classification of facial pain, general data, hereditary conditions, and previous diseases have been discussed in a preceding study. According to the character of the attacks the material has been classified into TTN = Typical Trigeminal Neuralgia (1/4), ATN = Atypical Trigeminal Neuralgia (1/4), and NNFP = Non-neuralgiform Facial Pain (1/2). The typical Trigeminal Neuralgia is a transitory, shooting pain, well defined. The other two groups are less well defined. The patients come to be treated by specialists 1-5 years after the onset of pain. The oral cavity is often perceived as the origin of the pain. A systematic examination shows that demonstrable pathological diseases in the masticatory organs are rarely connected with the pain condition. Dental treatment has provided poor results. Facial pain is a very constant phenomenon which does not- or only to a negligible degree--change over an agelong course. In the present material 8 characters of pain are used: Shooting-cutting, boring, squeezing-pressing, throbbing-hammering, dull, burning-smarting, prickling-sticking, paraesthetic. With the exception of a few cases of apoplexy and herpes zoster there is no pain reaction which can be referred to on an aethilogical basis.

Adult↗
PubMed1979

Ectopic pituitary adenomas.

We report here four cases representing different forms of ectopic pituitary adenomas localized: (1) in the nasal cavity, (2) in the sphenodial sinus, (3) on the sphenoidal wing and (4) on the petrous temporal bone. Ectopic pituitary adenomas may probably occur in extrasellar pituitary tissue deposited along the route of fetal development or as a result of intracranial dissemination of adenomatous cells during operation. It is assumed that in some cases ectopic pituitary tissue may retain endocrine function leading to a sustained pituitary function even after a radical hypophysectomy.

Adenoma↗
PubMed1978

Hereditary mirror movements--a case report.

A five-year-old girl with abnormal mirror movements is described. The phenomenon is observed in the distal parts of the extremities and is most marked in the hands. An extensive neuropediatric examination including computerized tomography of the brain has not revealed any further abnormalities, nor has it been possible to identify the pathogenetic mechanism. The clinical picture corresponds to that previously reported in cases of hereditary mirror movements--a condition with unknown pathogenesis affecting individuals that in other respects are neurologically normal. The disorder is considered to be dominantly inherited but in this case available data suggest a recessive mode of inheritance. There is no doubt that the girl of this report is getting increasingly embarrassed by her condition. Obviously mirror movements of this degree constitute a slight to moderate handicap.

Child, Preschool↗
PubMed1978

Pituitary adenoma and visual function. The prognostic value of clinical, ophthalmological and neuroradiologic findings in 51 patients subjected to operation.

The series studied included 51 patients subjected to operation for pituitary adenoma. The visual status was analysed both pre- and postoperatively. The pre- and postoperative parameters were compared with clinical information, ophthalmological and neuroradiological findings with a view to an evaluation of their prognostic value. In 36 patients with chromophobe adenoma, visual field defects were present in 92% before the operation; visual function improved in 62% and returned to normal in 24%. Among 15 patients with eosinophil or mixed adenoma, only two (13%) had visual field defects pre-operatively. In those patients where operation was followed by a distinct visual improvement, the pre-operative ophthalmological findings were as follows: visual acuity greater than 6/24, normal optic discs, visual field defects up to two quadrants, and pneumoencephalographic findings suggestive of only a small suprasellar tumour.

Adenoma↗
PubMed1977

Calcium deficiency, pregnancy, and lactation in rats. Microscopic and microradiographic observations on bones.

Adult female rats were subjected to a calcium-depriving regimen (calcium-deficient diet containing oxalate + pregnancy + lactation) to obtain maximum bone mineral mobilization in as short a time as possible. The femur and tibia were investigated by histological, microradiographic and fluorescent microscopic methods. The regimen caused osteoporosis, which varied in severity with the degree of calcium deprivation. Most of the bone tissue removed was taken from the metaphyseal trabeculae and from the endosteal surface of the diaphysis. The remaining bone tissue seemed unchanged. The cells responsible for the bone removal did not seem to be multinucleated osteoclasts, but mononuclear, hypertrophied, elongated cells, possibly derived from the "resting" osteoblasts normally lining the bony surfaces. No signs of osteocytic osteolysis were observed. Bone formation was reduced, but present even in the most calcium-deprived animals. No increase in the amount of osteoid was observed.

Animals↗