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Biomedical subjects

P Rasmussen

Publications and source records attributed to P Rasmussen.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Do pregnant women with a low-situated placenta in the 16th week constitute a risk group?].

The object of this investigation was to elucidate whether pregnant women with low-placed placentae in the 16th week of pregnancy had more frequent haemorrhagic complications during pregnancy or during delivery and to demonstrate how many had placenta praevia at the time of delivery. In addition, the frequency of Caesarean section, the perinatal mortality, birthweights under 2,500 g in the infants delivered and placental anomalies were registered. A total of 1,572 pregnancies were investigated sonographically at about the 16th week of pregnancy and in 166 (10.6%) the placenta was found in the lower uterine segment. 40% of the 15 women with complete placenta praevia at the 16th week of pregnancy developed haemorrhage necessitating hospitalization, 27% were delivered by Caesarean section and 20% had placenta praevia at delivery. Out of 99 women with partial placenta praevia at the 16th week of pregnancy, one was found to have placenta praevia at the time of delivery but no significantly increased risk of haemorrhage necessitating hospitalization, abortion or Caesarean section. In 52 women with "deep insertion" of the placenta at the 16th week of pregnancy, one was subsequently found to have complete placenta praevia but the frequency of complications was not increased as compared with that in women with a free orifice. This investigation reveals a basis for control sonography of women with complete placenta praevia at the 16th week of pregnancy.

Female↗
PubMed1990

Facial pain. I. A prospective survey of 1052 patients with a view of: definition, delimitation, classification, general data, genetic factors, and previous diseases.

1052 patients with facial pain have been examined and followed up by the author for an 18-year period. The patients are classified according to type of attack into: Typical Trigeminal Neuralgia (brief pain paroxysms with pain-free intervals). Atypical Trigeminal Neuralgia (pain paroxysms with intervals of pain or paroxysms lasting for minutes). Non-neuralgiform Facial Pain (pain lasting or occurring for long periods). The material was equally distributed between patients with Neuralgia and Non-neuralgiform Facial Pain. In the majority of cases Trigeminal Neuralgia occurred after the age of 50. Non-neuralgiform Pain mainly between 30 and 50. There is a majority of women with Non-neuralgiform Pain. No genetic factors could be demonstrated. A detailed registration of previous diseases in the central nervous system, the peripheral nerves, and the facial structures revealed no relation to important aetiological factors.

Adult↗
PubMed1990

Facial pain. II. A prospective survey of 1052 patients with a view of: character of the attacks, onset, course, and character of pain.

The material, definition, delimitation, and classification of facial pain, general data, hereditary conditions, and previous diseases have been discussed in a preceding study. According to the character of the attacks the material has been classified into TTN = Typical Trigeminal Neuralgia (1/4), ATN = Atypical Trigeminal Neuralgia (1/4), and NNFP = Non-neuralgiform Facial Pain (1/2). The typical Trigeminal Neuralgia is a transitory, shooting pain, well defined. The other two groups are less well defined. The patients come to be treated by specialists 1-5 years after the onset of pain. The oral cavity is often perceived as the origin of the pain. A systematic examination shows that demonstrable pathological diseases in the masticatory organs are rarely connected with the pain condition. Dental treatment has provided poor results. Facial pain is a very constant phenomenon which does not- or only to a negligible degree--change over an agelong course. In the present material 8 characters of pain are used: Shooting-cutting, boring, squeezing-pressing, throbbing-hammering, dull, burning-smarting, prickling-sticking, paraesthetic. With the exception of a few cases of apoplexy and herpes zoster there is no pain reaction which can be referred to on an aethilogical basis.

Adult↗
PubMed1989

Fibrous dysplasia of the skull with acromegaly and sarcomatous transformation. Two cases with a review of the literature.

Two cases of fibrous dysplasia of the skull are reported. Both patients were young women with acromegaly and were treated with radiotherapy. Progressive pareses of cranial nerves, pain, and a malignant course of the disease were characteristic in both patients, and the diagnosis of osteogenous sarcoma proved in one of them by histological examination. The clinical picture of fibrous dysplasia of the skull and the role of radiotherapy with the risk of development of malignancy is discussed.

Acromegaly↗
PubMed1988

Lipid X protects mice against fatal Escherichia coli infection.

Lipid X, the major monosaccharide precursor of lipid A, is nontoxic and has previously been shown to protect mice and sheep from the harmful effects of endotoxin. To test the hypothesis that lipid X could be therapeutic against infections with gram-negative organisms, neutropenic ICR mice were infected by intramuscular inoculation of Escherichia coli and subsequently treated with lipid X alone or in combination with the antibiotic ticarcillin. Lipid X slightly prolonged survival; treated mice had a significantly improved rate of survival 18 h after intramuscular inoculation as compared with controls (P less than 0.025). By 24 h, however, this difference disappeared. When lipid X was combined with ticarcillin, survival differences were both significant and prolonged. Treatment of mice with one to two doses of lipid X for a total dose of 1 mg intravenously and with 1,200 mg of ticarcillin per kg every 6 h improved survival over a 48-h treatment period from 5 to 23% (P less than 0.0025). Treatment with lipid X and ticarcillin over a broad range of antibiotic dosages in 362 mice demonstrated improved survival of two- to fourfold (P less than 0.0001 at 24 h after inoculation, P less than or equal to 0.0005 at 48 h, and P less than or equal to 0.0001 at 5 days). Lipid X enabled the dose of ticarcillin necessary to protect 50% of mice from death to be reduced by two- to fivefold. Pretreatment with lipid X was not necessary to improve survival: 16 of 17 (94%) infected and visibly ill animals that received lipid X and ticarcillin 6 h after thigh inoculation survived versus 30 of 44 (68%) control animals treated with ticarcillin alone (P less than 0.0001). Lipid X had no antimicrobial activity in vitro. Lipid X is a novel agent that enhances survival in an animal model of severe infection with gram-negative organisms.

Animals↗
PubMed1987

Maintenance etidronate in the prevention of malignancy-associated hypercalcemia.

Normocalcemic patients with cancer who had been successfully treated for an episode of hypercalcemia were enrolled in a randomized, multisite, double-blind, placebo-controlled trial designed to determine the efficacy of maintenance oral etidronate in preventing the recurrence of moderate to severe hypercalcemia (serum calcium level, greater than 11.5 mg/dL [greater than 2.87 mmol/L]). Ten (40%) of 25 etidronate-treated patients and 17 (46%) of 37 placebo-treated patients had recurrence of hypercalcemia within 150 days. Although patients taking etidronate had a longer time to the development of hypercalcemia (median, 55 days vs 28 days), this was not significantly different from the control group. The high attrition rate in this trial from hypercalcemia and other malignancy-related causes represents a major difficulty in conducting studies with agents that may require prolonged administration before producing a therapeutic effect.

Administration, Oral↗
PubMed1986

Chronic facial pain following diseases affecting the maxillary antrum. The influence of peripheral impulses from the maxillary air sinus is not significant in their maintenance.

For the purpose of examining the significance of a pain focus in the maxillary air sinus denervation of the mucosa of the sinus by transantral maxillary nerve section was performed. The material comprises 20 patients with pain in the distribution of the infraorbital nerve and previous disease of the relevant sinus. All patients had been treated previously without any benefit from peripheral surgery of the infraorbital nerve. Only 20% had any benefit of the proximal avulsion for more than three months. It is concluded that impulses from the mucosa of the maxillary sinus do not play any part in the occurrence or persistence of facial pain in this highly selected material.

Adult↗
PubMed1986

Effect of calcium deprivation on rat dams on fetuses and newborn offspring.

Calcium-deficient rats were put to breeding, and fetuses and offsprings were collected at 18 days in utero, at birth, and at 5-10 days post partum. Furthermore, blood and milk were collected from the dams, and blood from the offsprings. The rat pups had normal weights at 18 days in utero and at birth, whereas at 5-10 days post partum the growth was significantly reduced. The relative amount of total solids in the body was also decreased at 5 and 10 days post partum (increased water content). Despite the fact that serum Ca in the dams was severely reduced, the calcium content in the serum of the offspring was only moderately lowered, and there was no correlation between serum Ca in dams and offspring. The content of total solids in the rat milk was increased, whereas the calcium content remained unchanged. The body content of Ca and P in the rat pups was decreased only at 5 and 10 days post partum. The degree of reduction was nearly the same for all these elements, amounting to 15-19% at 5 days post partum and 38-40% at 10 days post partum. If, however, the content of the elements was calculated as percentage of total body solids, a significant increase was found for all of them at 5 and 10 days post partum. Significant differences in Ca:P ratios were not found at any age.

Animals↗
PubMed1986

Prospective evaluation of carcinoembryonic antigen levels and alternating chemotherapeutic regimens in metastatic breast cancer.

Ninety-seven eligible and evaluable women with metastatic breast cancer were placed on a prospective clinical protocol to evaluate the use of continuous cyclic therapy with dibromodulcitol, doxorubicin, vincristine, tamoxifen, and fluoxymesterone (DAVTH) v DAVTH alternating with cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP); and the use of pretreatment and serial carcinoembryonic antigen (CEA) levels in these patients. Continuous DAVTH and DAVTH/CMFP were equivalent therapies with respect to response rates, time to treatment failure (TTF), and survival. Pretreatment CEA levels were elevated (greater than 5 ng/mL) in 42/97 patients and less than 5 ng/mL in the remaining patients. Patients with elevated pretreatment CEA levels were more likely to be estrogen receptor (ER) positive (P = .006), to have prolonged disease-free intervals (P = .017), to have hepatic (P = .004) and/or osseous (P = .01) metastases, and to have multiple sites of metastatic disease (P = .004). Pretreatment CEA levels did not significantly predict for overall response rates, TTF, or survival; nonetheless, those patients with low pretreatment CEA levels had more complete responses (CRs) (16/55 v 4/42; P = .02). Serial CEA levels during therapy revealed a number of interesting patterns. During the first 4 months of treatment, serial CEA levels in responding patients either (1) progressively declined (15/29 women with elevated pretreatment CEA levels), or (2) initially rose significantly (mean, 243% of pretreatment value) and then declined (14/29 women with elevated pretreatment CEA levels). Peak CEA levels in the latter patients were seen 27 to 135 days following initiation of cytotoxic therapy. In some patients the initial increase in the CEA level was incorrectly interpreted as evidence of impending disease progression. CEA levels frequently increased around the time of clinical disease progression. However, rising CEA levels rarely provided a clinically meaningful lead time before the appearance of other clinical evidence of disease progression. These data suggest that routine pretreatment and monthly serial CEA levels in metastatic breast cancer patients have minimal use in clinical practice. Two further noteworthy findings were observed in this prospective study. First, patients with an unknown ER status had a prolonged median survival when compared with patients with ER positive or negative tumors; this appeared to be related to prolonged disease-free intervals in ER unknown patients. Second, two case of secondary acute leukemia were seen in patients treated with continuous DAVTH therapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

"Forme fruste" of Rett syndrome--a case report.

We report on a 17-year-old girl considered to represent a "forme fruste" of Rett syndrome. The history showed normal psychomotor development until age 20 months, when the girl successively lost acquired speech and developed autistic traits, moderate dementia, partial apraxia and microcephaly. However, she never stopped using her hands purposefully, nor did she develop the hand stereotypies characteristic of Rett syndrome. From age 4 years she successively became more communicable and regained some of the previous abilities including some speech. At 17 she showed most of the abnormalities characteristic of adolescent girls with Rett syndrome but was still only moderately retarded, with remarkably preserved motor functions. She had a peculiar apraxia. She seemed to lack "the key" to using her hands, while retaining a pincer grasp and some manipulative skills in her fingers. - It is suggested that the phenotype of Rett syndrome can vary considerably and that "formes frustes" may not be an exceptional rarity among mentally retarded girls.

Adolescent↗