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Biomedical subjects

P Probst

Publications and source records attributed to P Probst.

At least 163 records · Page 9Linked to original sources
PubMed1979

[Scintigraphy in cardiomyopathy].

The function of the right ventricle (RV) and left ventricle (LV) was evaluated in 32 patients with congestive cardiomyopathies (COCM), 10 patients with hypertrophic cardiomyopathy (HOCM) and 21 normal subjects (N). In all these patients myocardial perfusion was analysed using quantitative 201 Tl myocardial perfusion imaging. In COCM parameters of RV and LV performance were significantly reduced (p less than 0.01); regional wall motion analysis revealed a reduced radial shortening ability. Regional Tl-distribution was not different in COCM and N; however, relative Tl-uptake was significantly reduced (p less than 0.05). 80% of all patients with COCM showed the RV free wall on Tl-perfusion scintigrams. These scintigraphic aspects allow a noninvasive differentiation of a disturbed LV function and the classification of coronary and primary myocardial etiology. In patients with COCM the scintigraphically determined thickness of septum and free wall of LV was increased as compared to N (p less than 0.05). The ratio septum/lateral wall of LV averaged 1.3 +/- 0.20. Quantitative analysis of regional Tl-uptake revealed increased segmental relative Tl-uptake. In the majority of patients there was a disproportionate septal hypertrophy on the gated blood pool scan in LAO. These radionuclide techniques allow a dynamic two-dimensional evaluation of the interventricular septum and the LV.

Cardiomegaly↗
PubMed1979

[The reliability of needle puncture in the diagnosis of benign renal cysts? (author's transl)].

Confirmation of the diagnosis of a benign renal cyst through needle puncture is being reported with increased frequency. The puncture reveals either a clear, cloudy or bloody fluid, or no fluid at all. The authors analyze 88 of their own and 805 cyst punctures from the literature. A benign cyst was always present when the aspirated fluid was clear (763 cases). When the aspirated fluid was cloudy or bloody (130 cases) a malignant kidney tumor was found in 35% of the cases. Complications from cyst punctures are described. The authors feel that needle puncture is a highly effective method in the differential diagnosis of renal masses. It can also be used when multiple cysts are present on one or both sides.

Biopsy, Needle↗
PubMed1979

[Morphology of coronary vessels in coronary heart disease. An analysis of 930 coronary angiograms].

Coronary anatomy was analyzed in 930 patients who underwent coronary arteriography because of coronary artery disease. There was a slight predominance of single vessel disease, whereas double and triple vessel disease were equally distributed. A left main (LM) lesion was found in 5.2%, with an additional right coronary artery lesion in 3.3%. The left anterior descending (LAD) artery was involved most frequently, followed by the right coronary artery (RCA) and left circumflex (Cx). The LAD demonstrated more often a proximal stenosis than the RCA and Cx. If the LM is associated with a RCA-stenosis then the LAD and Cx are involved more commonly, suggesting a more advanced disease in all major vessels. The analysis of ventricular function revealed a significant deterioration according to the number of diseased vessels. If the LM is associated with a RCA lesion, then the hemodynamics are similar to a 3-vessel disease, whereas isolated LM lesions are associated with good ventricular function according to the lesser degree of coronary sclerosis. The deterioration of the hemodynamics in correlation with coronary vessel involvement is significant, however due to the large standard deviations conclusions for the individual patient can not be drawn.

Coronary Angiography↗
PubMed1978

A variation of scimitar syndrome.

Variations of the scimitar syndrome have been reported previously, the most common being the absence of systemic arterial supply to the right lung and varying degrees of lung hypoplasia. Anomalous scimitar-like veins draining the entire right lung and connecting normally to the left atrium have been reported. The case presented is unique in that there is marked hypoplasia of the right bronchial tree and a large bronchogenic pulmonary cyst without dextroposition of the heart and anomalous systemic arterial supply to the right lung.

Abnormalities, Multiple↗
PubMed1978

Percutaneous transhepatic drainage catheter: a valuable therapeutic aid in obstructive jaundice.

Percutaneous decompression of the biliary system is a useful and well established procedure which can be carried out with negligible risk and may be of great benefit to the patient. The main indications are pre-operative decompression and primarily decompression of patients with inoperable obstructive neoplastic disease. In order to provide drainage, the catheter should be advanced under fluoroscopic control into one of the major radicles ore preferably into the distal common duct beyond the point of obstruction. This ideal internal drainage into the duodenum was accomplished in the reported patient with sclerosing cholangitis who was markedly improved by this procedure.

Catheterization↗
PubMed1978

Which embolic material is best suited for which embolization procedure?

Various embolization cases are described, and these require certain embolization materials. In our experience Gelfoam particles are very well suited for gastrointestinal tract lesions. Ivalon shavings gave excellent results in congenital arteriovenous malformations with permanent occlusions. Bristle brushes are a new device for larger artery occlusion. Stainless steel coils in combination with silk tufts proved thrombosis of large AV fistuals or of aneurysms particularly of the splenic artery.

Abdominal Injuries↗
PubMed1978

Nonsurgical treatment of splenic-artery aneurysms.

Splenic-artery aneurysms are commonly found incidentally during abdominal angiography. Because approximately 10% of these aneurysms may rupture and lead to fatal hemorrhage, surgical treatment is indicated. A new, nonsurgical approach is described in which the splenic-artery aneurysm is packed with foreign matter introduced through a catheter to induce thrombosis. The procedure can be carried out under local anesthesia and is the preferred technique in high-risk patients. As more experience is gained with this procedure, it can be performed on an elective basis under local anesthesia and the patients can be spared the disadvantages of laparotomy.

Aged↗
PubMed1978

The use of the bristle brush for transcatheter embolization.

Small nylon brushes with a stainless steel core have been found safe and effective for transcatheter arterial occlusion. Studies performed in 14 dogs demonstrate the brushes result in rapid occlusion of the renal artery. Follow-up studies for periods up to ten months document the safety and permanence of the occlusion. The animal studies reported herein suggest that these devices can be safely used in humans in cases where large artery occlusion is desired.

Animals↗
PubMed1978

Improved safety of splenoportography by plugging of the needle tract.

Splenoportography, a useful preoperative diagnostic procedure in patients with portal hypertension, has been largely discontinued because of the risk of hemorrhage. We have used both Ivalon and Gelfoam in particle and plug form to plug the needle tract after splenoportography. Initial studies were conducted on six dogs. Plugging of the needle tract by injection of suspensions of small Gelfoam or Ivalon particles resulted in intravasation of these particles into the splenic vein. This was demonstrated by radioactive tagging of particles and the direct collection of splenic blood during the intrasplenic injection. Plugging of the splenic needle tract with compressed Gelfoam caused immediate, complete cessation of bleeding in fully heparinized animals. Because of these experimental results, five humans with decreased platelet counts and severe portal hypertension underwent successful splenoportography without significant hemorrhage. At surgery, successful plugging of the needle tract by Gelfoam was confirmed.

Adult↗
PubMed1978

[Oculoauriculovertebral dysplasia (author's transl)].

A case of okulo-aurikulo-vertebral syndrome in a three year old girl is described. The similarities between the maxillary arch syndromes are emphasized on the one hand and on the other the relatively frequent occurrence of congenital unilateral facil palsy with congenital cardiac defects is outlined. Aetiological hypotheses are discussed.

Abnormalities, Multiple↗
PubMed1978

[Effect of meproscillarin on left ventricular hemodynamics (author's transl)].

In 10 patients with angiographically proven coronary artery disease we investigated the influence of the glycoside 14-hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) on left ventricular performance with invasive methods. After a single i.v. bolus injection a decrease in left ventricular end-diastolic pressure associated with an increase of the maximum rate of pressure rise (dp/dtmax) and left ventricular pressure (LVP) was observed. These changes were not accompanied by significant alterations of the heart rate during an observation period of 60 min.

Cardiac Glycosides↗
PubMed1978

Assessment of regional wall motion in coronary artery disease using radionuclide methods.

72 patients with CAD, 10 patients with congestive cardiomyopathies and 10 normal subjects were evaluated by radionuclide angiography. Comparison with contrast angiography showed good results for LVEF (r = 0.83). Regional asynergies observed in the radionuclide angiography correlated well with defects in thallium scintigrams. Extent of abnormal wall motion was measured and compared with normals, appreciating the deviation from the normal mean radial shortening. Good correlation could be demonstrated with radionuclide ventriculography. In 80% of congestive cardiomyopathies the right ventricle wall became visible in the thallium scintigram.

Cardiomyopathies↗
PubMed1977

[Behaviour of erythrocytes in patients with aortic of mitral stenosis (author's transl)].

The behaviour of red blood cells was studied in 17 patients with aortic stenosis and 14 patients with mitral stenosis. Anemia was present only in 1 out of 17 patients with highgraded aortic stenosis. 8 of the 17 patients showed a reduced survival time of the red blood cells indicating hemolysis in a compensated stage. 14 cases of mitral stenosis showed no evidence of hemolysis. There was a significant inverse relationship (r = --0,85) between the valve gradient and the survival time of the erythrocytes in patients with aortic stenosis; valve area and survival time were directly related (r = 0,75). In mitral stenosis, there was no significant correlation between gradient or valve area and survival time. This suggests that the gradient through the valve rather than the reduced valve area is responsible for the damage of the erythrocytes; in addition, hemolysis appears to be dependent on pressure gradient rather than on valve pathology or reduction of valve area per se.

Anemia↗