Biomedical subjects

P Probst

Publications and source records attributed to P Probst.

At least 199 records · Page 11Linked to original sources

PubMed1975

[Angiography in acute gactrointestinal hemorrhage].

The indications for and diagnostic value of visceral angiography in 30 cases of acute gastrointestinal bleeding are discussed. In one third of these emergency angiograms the etiology of the bleeding could not be demonstrated. In two thirds of the cases the source of bleeding was successfully localized. In half the positive angiograms the bleeding site was shown directly in the form of extravasation of contrast, while in the remaining half pathological findings were demonstrated without evidence of contrast media extravasation.

Adult↗

PubMed1975

[Radiological diagnosis of closed trauma to the aorta (author's transl)].

Closed injury to the thoracic aorta at the isthmus occurred after street accidents in eight persons (five males, three females, aged 17-55 years). The lesions ranged from isolated intimal rupture to complete loss of continuity of the aorta. Radiological diagnosis or thoracic surgical exploration took place in five patients within 48 hours of the accident, while in the remaining three--alle with a false aneurysm of the thoracic aorta-the time elapsed before accurate diagnosis ranged from three months to seven years. Five patients were successfully operated upon. It is stressed that successful surgical intervention depends on early and accurate radiological diagnosis (chest X-ray and, if necessary, aortogram).

Accidents, Traffic↗

PubMed1975

Inefficacy of "therapeutic" serum levels of digoxin in controlling the ventricular rate in atrial fibrillation.

Although therapeutic and toxic serum concentrations of digoxin have been established, there is sparse information permitting correlation of drug level with clinical effect. This study was undertaken to assess the radioimmunoassay serum digoxin levels in 30 patients with acute atrial fibrillation (38 determinations) and 30 patients with chronic atrial fibrillation (54 determinations). Those with chronic fibrillation were subdivided into those in clinically stable condition (14 patients), and those seriously ill and in clinically unstable condition (16 patients). Slowing of ventricular rate in patients with stable, chronic atrial fibrillation was accomplished in 10 of 16 instances by "therapeutic" and "subtherapeutic" levels of digoxin (less than 2 ng/ml). Ventricular rate was "controlled" (65 to 95 beats/min) with therapeutic levels of serum digoxin in only five instances of acute atrial fibrillation and seven of unstable chronic atrial fibrillation. In 43 studies (23 of acute atrial fibrillation, 20 of chronic atrial fibrillation), a rapid ventricular rate (95 to 140 beats/min) persisted in the presence of "therapeutic" or high levels of digoxin. Thirty-nine of these were in patients who were seriously ill with conditions such as infection, hypoxia or recent thoracotomy. Slowing of the ventricular rate required "toxic" concentrations of digoxin (2.5 to 6 ng/ml) in 15 instances. We conclude that sufficient amounts of digoxin to achieve "therapeutic" serum concentrations may fall to lower the ventricular rate in atrial fibrillation to less than 100 beats/min, especially when a serious, complicating illness coexists.

Atrial Fibrillation↗

PubMed1975

[Bloodgas changes during heart catheterisation in children under basal sedation (author' transl)].

A form of basic sedation for cardiac catheterisation in children with congenital heart disease is described. The drugs used (Toronto cardiac mixture, papaveretum--hyoscine respectively) offer a true alternative to general anesthesia. Blood gases and acid-base status of 32 children aged two days to twelve years were investigated. The observed tendency towards metabolic acidosis is believed to be related to the angiographic contrast medium.

Acid-Base Equilibrium↗

PubMed1975

[Indication for preventive pacemaker implantations in patients with severe disorders of atrioventricular conduction].

A method for the evaluation of patients with severe conduction disturbances who might develop Adams-Stokes attacks or total A-V block is described. In 9 patients with conduction disturbances a "stress test" of the conduction system with small dosis of Ajmalin was performed. In 2 patients a higher degree of A-V block developed (2: 1 block, total A-V block). These patients were considered as candidates for prophylactic pacemakerinsertion. During this procedure a temporary pacemaker electrode has to be put into the right ventricle to provide saftey for the patient.

Adult↗

PubMed1975

[Electric stimulation as a means for the diagnosis of atrioventricular conduction disorders].

A patient with 2 : 1-block and right-bundle-branch block is described, who developed a high-degree-AV block distal to the bundle of His during electrophysiological investigations. Rapid atrial pacing caused total AV block distal to the His bundle. Rapid pacing from the right ventricle also caused total AV block after sudden discontinuation of pacing. The duration of total AV block was 25 to 60 seconds and the preautomatic time 2300-4750 msec according to rate and duration of stimulation. These methods are considered as good tools to evaluate patients with severely diseased conduction system, who might develop total AV block or Adams-Stokes seizures.

Adams-Stokes Syndrome↗

PubMed1975

[Apexcardiography in coronary disease].

The value of the apex cardiogram (AKG) for identification of diastolic extrasounds is established. The present study attempts to correlate the so called a-wave index and the systolic portion of the AKG-curve with the results of left heart catheterisation in 15 patients with coronary heart disease (KHK). The position of point U (the lowest point between the first and the second systolic wave) during mechanical systole and the relative height of the second systolic wave do not correlate with LVEDP, dp/dt and the a-wave index. In contrast to a group of 22 healthy persons the a-wave index of the KHK-patients was significantly higher (17.5% vs. 5.7% on average) and the position of point U was significantly earlier (42.5% vs. 62% on average, of the duration of mechanical systole).

Adolescent↗

PubMed1975

[Dependability of various catheter systems for the determination of contractility parameters].

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Animals↗

PubMed1975

[Effect of potassium-magnesium aspartate on hemodynamics and myocardial metabolism of coronary disease patient during beta receptor stimulation].

2 series of patients with angiographically proven coronary artery disease were studied under the influence of an infusion of a beta-receptor stimulating drug (heptaminole) and of kalium-magnesium-aspartate (KMA) in high (series: I: 1000 mg of heptaminole in 25 min) and low doses (series II: 200 mg of heptaminole in 25 min) of beta-receptor stimulation. The results confirm the finding that high dose beta-receptor stimulation in patients with severe coronary artery disease results in failure of the contractile mechanism of the heart with the beta-receptor angina. However, administration of KMA simultaneously with the beta-receptor stimulator seems to be able to prevent the expected decrease of lactate extraction and results in no change in lactate AVD in series I and even in an 11% increase in lactate AVD in series II. Experimental data concerning the biochemical effects of KMA suggest that its ability to provide adequate amounts of oxaloacetone and hence to improve the function of the bricarbonic acid cycle seems to be of special importance. For this action to become relevant in coronary artery disease a situation would have to be postulated, in which an additional limiting factor of oxydative metabolism would be an inadequate supply of Krebs-cycle intermediates.

Acetoacetates↗

PubMed1975