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Biomedical subjects

P Phillips

Publications and source records attributed to P Phillips.

At least 253 records · Page 14Linked to original sources
PubMed1979

Status of granuloma inguinale in Papua New Guinea.

Granuloma inguinale has been endemic in Papua New Guinea for at least eighty years and recently appears to be increasing, particularly in the urban centres. Most patients were found to be recent migrants to the Port Moresby area with low socioeconomic status and poor personal hygiene. The disease was found more frequently in males. A possible association between carcinoma of the penis and granuloma inguinale was observed. Lesions were chronic, progressive and located mainly in the genital region. Attempts to culture the causative agent were unsuccessful.

Adolescent↗
PubMed1979

Isolation and characterization of endothelial cells from rat and cow brain white matter.

A procedure is described for obtaining pure cultures of endothelial cells from rat and cow brain white matter. The morphology of the tissue-cultured cells was studied by both light and transmission electron microscopy. Weibel-Palade bodies, described in the literature as specific for endothelial cells, appeared in small numbers in our cultured cells. Autoradiographic, scintillation counting, immunological and histochemical studies were performed. The usefulness of pure endothelial cell cultures is discussed.

Alkaline Phosphatase↗
PubMed1977

Jaw wiring in treatment of obesity.

17 patients with severe (median percentage above ideal weight 100%) and resistant obesity underwent jaw wiring. There were no major complications and patients tolerated the procedure and subsequent minor inconveniences. All patients lost weight at a rate (median 25-3 kg in six months) comparable with that of intestinal bypass surgery and one achieved and maintained her ideal weight. Two-thirds of the patients, however, regained some weight after the wires were removed. Jaw wiring is a simple effective procedure which can be carried out in most hospitals, and has a place in an integrated approach to obesity.

Adolescent↗
PubMed1976

Tumour angiogenesis factor (TAF) in human and animal tumours.

Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcutaneous fascia or rats. Controls, e.g. similar extracts of rat liver or human kidney, did not induce neovascularisation. The endothelium of newly-formed blood vessels contained many mitotic figures. A limitation of this method is that it is qualitative only. In order to develop a quantitative in vitro assay for a tumour angiogenesis factor (TAF), short-term primary cultures were initiated from adult rat brain white matter, as cells from such cultures were shown to be vascular in origin. Addition of fractions containing TAF (B and C) which were active in vivo failed to stimulate thymidine uptake by the cells. The possible reasons for this failure and the therapeutic potential of TAF in cancer control are discussed.

Adenocarcinoma↗
PubMed1976

Sport-related attitudes and the-Philosophies of Human Nature Scale.

The revised Philosophies of Human Nature scale was presented to 94 females and 94 males to develop normative data. There were no significant sex differences in the norms. A questionnaire about sports was presented at the same time to determine relationships between the two scales. Females who claimed frequent sports participation were less likely to have an internal locus of control and were less likely to believe that human beings are complex than females who claimed infrequent participation. A comparison of those who like and dislike sports gave no significant difference for either sex on the sub-scales of Philosophies of Human Nature. The findings are consistent with previous research which generally shows little or no effect of interest or participation in sports on personality traits.

Adult↗
PubMed1973

A new device for assessing motor skills in the rat.

An automated climbing apparatus to test locomotor capacity in rodents is described along with programming circuitry and a description of the printed circuit process. Past application is noted and in addition future uses are suggested.

Animals↗