Search PubMed⌕ Search

Biomedical subjects

P Phillips

Publications and source records attributed to P Phillips.

269 records · Page 15Linked to original sources
PubMedDate not supplied

Invasive hyalohyphomycosis caused by Scopulariopsis brevicaulis in a patient undergoing allogeneic bone marrow transplant.

Scopulariopsis brevicaulis is a common soil saprobic mould. Occasionally, S. brevicaulis has been reported as an etiologic agent of human disease. The spectrum of human mycoses includes toenail infection, hypersensitivity pneumonitis, fungus ball formation in a preformed pulmonary cavity, and, most recently, documented deep tissue infections in immunocompromised hosts. A case of invasive hyalohyphomycosis of the great toe caused by S. brevicaulis is reported in an allogeneic bone-marrow transplant recipient.

Adult↗
PubMedDate not supplied

Invasive external otitis caused by Aspergillus.

Invasive external otitis occurs almost exclusively in patients with longstanding diabetes. Except for occasional cases, the etiologic agent has been Pseudomonas aeruginosa. We report a case caused by Aspergillus species in a diabetic patient with acute leukemia. Persistent infection was documented by culture and histology after a course of intravenous amphotericin B (total dose, 2 g). Clinical resolution occurred in association with a 3-month course of oral itraconazole. Four previously reported cases of invasive aspergillus otitis are reviewed.

Aspergillosis↗
PubMedDate not supplied

Exchange transfusion as an adjunct to the treatment of severe falciparum malaria: case report and review.

Malaria associated with complications or a fatal outcome is almost always caused by Plasmodium falciparum. The mortality due to this disease parallels the degree of parasitemia. Successful use of exchange blood transfusion as a therapeutic adjunct for this infection was first reported in 1974, although the efficacy of this procedure has not been established by randomized, controlled trials. The rationale for this form of therapy is based on: (1) rapid reduction in the parasite load by direct removal; (2) decreased risk of severe intravascular hemolysis and its consequences (disseminated intravascular coagulation and renal dysfunction); (3) improved rheology with transfused blood and reduced microcirculatory sludging; and (4) improved oxygen-carrying capacity with transfused erythrocytes. We describe a case of severe falciparum malaria and review the literature describing the use of exchange transfusion for treatment of this infection.

Adult↗
PubMedDate not supplied

Tolerance to and efficacy of itraconazole in treatment of systemic mycoses: preliminary results.

Twelve patients with mycotic infections were treated with itraconazole during a one-year period. Patients had the following conditions: coccidioidomycosis (three), histoplasmosis (three), mucocutaneous candidosis (two), aspergillosis (three), and urinary tract infection due to Torulopsis glabrata (one). The daily dose of itraconazole ranged from 100 to 200 mg. Ten of the 12 cases were assessable. Clinical improvement was observed in six patients, two with coccidioidomycosis, two with mucocutaneous candidosis, one with histoplasmosis, and one with aspergilloma. Four patients did not respond to therapy; two of these patients had aspergillosis, one had histoplasmosis, and one had T. glabrata infection. No adverse effects were attributable to itraconazole.

Adult↗
PubMedDate not supplied

Editorial: Think.

Explore the source record for details and available documents.

Adaptation, Psychological↗
PubMedDate not supplied

Neonatal pain management: a call to action.

Pain is a complex phenomena that is at best illusive in the neonate. Pain management has become a hot topic in the neonatal field due to recent research on neonatal pain response that is changing the way we view pain perception and management. Specific information on the assessment and treatment of pain in neonates is offered along with methods of strategic planning to assist nurses to advocate for improved neonatal pain management.

Humans↗
PubMedDate not supplied

Family-centered care at home for families with children who are technology dependent.

The philosophy of family-centered care recognizes parents as equal in partnerships with professionals. An adapted nursing process can provide a useful mechanism for members of this partnership to create and maintain a system that promotes an optimal quality of life at home for children who are technology dependent and their families. A family-centered assessment requires the nurse to facilitate the family's self-assessment and promote a family systems perspective. The family and the nurse together develop a plan of care, with the family establishing priorities. The nurse assumes joint responsibility with the family in implementing the plan of care, and promotes the principle of normalization and the use of informal options whenever possible. Evaluation is formal, informal, and ongoing and includes the family and nurse's evaluation of both outcome and process.

Adult↗
PubMedDate not supplied

Amphotericin B use in a major acute care hospital.

A retrospective study was undertaken to assess the use of the antifungal agent amphotericin B in a major acute care hospital. Data were reviewed from 82 patients who were prescribed amphotericin B at Vancouver General Hospital between March 1 and September 1, 1990. Sixty-one percent of the patients treated with amphotericin B were from the hematology service, 22% were from the intensive care unit (ICU) service, and the remainder were from other hospital services. Fever of unknown origin was the most common reason for amphotericin B use in the hematology patients, while candidemia was most prevalent in the ICU patients. Renal dysfunction during treatment was common and related to the dose received. Test doses were used in the majority of courses, and premedications were also common. Cumulative doses administered were typically lower than intended. Amphotericin B treatment was considered successful in 46% of the cases reviewed. This review provides insight into how amphotericin B is used at one hospital and how this use may be improved. Potential applications for fluconazole are also discussed.

Adult↗
PubMedDate not supplied

Diabetes and the menopause. Special considerations.

The menopause marks an important transition into the last third of a woman's life. It gives the woman and her health professionals an opportunity to review health risks, plan preventive activities, and establish monitoring strategies. This is especially important in women with diabetes because of the compounding menopausal cardiovascular risk and those associated with diabetes. The importance of the menopause is often not appreciated by women with diabetes, nor by their health professionals, and opportunities to avoid future problems may be missed. This article emphasises the importance of cardiovascular protection and the special value of hormone replacement therapy in women with diabetes at and beyond the menopause.

Aged↗