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Biomedical subjects

P Phillips

Publications and source records attributed to P Phillips.

At least 235 records · Page 13Linked to original sources
PubMed1983

Nocturnal penile tumescence with stamps: a comparative study under sleep laboratory conditions.

The usefulness of nocturnal penile tumescence with stamps to measure erections during sleep has been evaluated under laboratory conditions and compared to strain gauge recording. If the ring of stamps does not break a diagnosis of organic dysfunction is supported. However, if breakage occurs at the perforations no diagnostic conclusion can be made. The diagnostic importance of nocturnal penile tumescence with stamps is limited.

Adult↗
PubMed1983

Relationship of angiogenesis factor in synovial fluid to various joint diseases.

A low-molecular-weight freely dialysable angiogenesis factor has been isolated from 49 synovial fluids obtained from patients with various joint diseases. An analysis of disease type and incidence of freely dialysable angiogenesis activity showed that the osteoarthrotic group had a significantly higher incidence than all the other groups (p = 0.0332). Angiogenesis factor has also been detected in a bound form in the retentates of fluids which gave positive results for dialysable factor. The possibility that an imbalance between carrier-bound and free factor may have a causative role in disease is discussed.

Angiogenesis Inducing Agents↗
PubMed1983

Seclusion and restraint and prediction of violence.

The authors studied the use of seclusion and restraint on an inpatient unit in a state psychiatric hospital. Of 69 randomly selected inpatients, 51% experienced seclusion or restraint at least once. More psychotic than nonpsychotic patients required seclusion or restraint. However, neither psychosis/nonpsychosis nor voluntary/involuntary admission status predicted the likelihood of violent threats or actions. Patients experiencing seclusion and restraint showed a nonsignificant trend toward longer mean length of stay in the hospital. The frequency of patient behavior leading to seclusion or restraint appeared to be directly related to the stimulation caused by the presence of many staff members and other patients.

Adolescent↗
PubMed1983

Protein turnover in the elderly: a comparison between ill patients and normal controls.

Total body protein turnover was measured in a group of ill geriatric patients and compared with healthy elderly controls. The subjects were fed a liquid formula and a tracer dose of [15N]-glycine by nasogastric tube. Total body nitrogen flux and hence protein synthesis and breakdown rates were calculated from the abundance of 15N in urinary ammonia. Urinary creatinine excretion and plasma albumin were also measured. The ill subjects had significantly higher total body nitrogen flux (P less than 0.025), protein synthesis (P less than 0.025) and breakdown rates (P less than 0.025) and significantly lower plasma albumin (P less than 0.01) and 9-h creatinine excretion (P less than 0.01) than the control group. This increase in protein turnover in spite of a reduced muscle mass in the ill subjects appears to be mainly due to the effects of tissue trauma and inflammation.

Aged↗
PubMed1982

A low-molecular-weight angiogenic factor in cat retina.

A low-molecular-weight angiogenic factor has been isolated from healthy adult cat retinas. The factor, which has been purified by diethylaminoethyl (DEAE) cellulose chromatography and affinity chromatography, stimulates neovascularisation of the chick chorioallantoic membrane and has a number of properties similar to those previously described for a tumour factor. The finding of an angiogenic factor in healthy retina and its relationship to previously described inhibitors of angiogenesis is discussed.

Angiogenesis Inducing Agents↗
PubMed1982

Purified tumour angiogenesis factor enhances proliferation of capillary, but not aortic, endothelial cells in vitro.

Purified tumour angiogenesis factor (TAF) obtained from rat Walker 256 carcinoma and found to induce neovascularization in vivo was examined for its effect on endothelial cell cultures of capillary (CBEC), cow aorta (CAEC) and pig aorta (PAEC) in vitro. Treatment with TAF increased the growth of capillary but not aortic endothelial cells, and then only when the cells were growing on a native collagen substratum. These data show an important growth difference between endothelial cells, in that the ability to proliferate in response to TAF depends not only on the substratum used but also on the vascular origin of the cells.

Angiogenesis Inducing Agents↗
PubMed1981

Delayed appearance of a circulating myocardial depressant factor in burn patients.

Fourteen burn patients and four normal controls were studied for the plasma activity of a myocardial depressant factor (MDF). The mean age of the burn patients was 40.4 years and the burn area was 61.9% of body surface. MDF activities were 28 +/- 3 units in the burn patients on day 1 and 56 +/- 4 units on days 4 and 5. This compares with 23 +/- 3 units for the control patients. Despite maintenance of high cardiac output by fluid therapy, only three of the 14 patients (21%) survived. Our data show the presence in burn patients of MDF, which may contribute to high mortality rates in these patients.

Adult↗
PubMed1981

Puerperal haematological indices.

Haematological indices were studied serially in 33 healthy women, at one week before delivery, during the first six days of the puerperium, at six weeks and six months post partum. Red cell count, haemoglobin concentration and haematocrit decreased during the first four days of the puerperium; haemoglobin concentrations up to 3.5 g/dl less than pre-delivery values were recorded in the absence of clinical postpartum haemorrhage. The second puerperal day haemoglobin concentration correlates most closely with the six week postpartum value. A leucocytosis of greater than 20 X 10(9)/1 was found on the first puerperal day in 15 per cent of the women studied.

Erythrocyte Count↗
PubMed1980

Angiogenic factor from synovial fluid resembling that from tumours.

Synovial fluids from 2 of 2 patients with osteoarthritis, 2 of 8 with rheumatoid arthritis, and 2 of 2 with ankylosing spondylitis contained a low-molecular-weight angiogenesis factor apparently identical with that derived from tumours. The amount of factor present was highest in patients with osteoarthritis, 2 patients with psoriatic arthropathy gave negative results. It is suggested that angiogenesis factor is involved, directly or indirectly, in the production of synovial exudate.

Adult↗
PubMed1980

Stimulation by a low-molecular-weight angiogenic factor of capillary endothelial cells in culture.

A low-mol.-wt compound isolated from rat Walker 256 carcinoma and found to induce neovascularization in vivo was tested on cultures of cow brain-derived endothelial cells (CBEC) growing on plastic and collagen substrates. This factor had a mitogenic effect on CBEC cultured on native collagen gels and for this reason has been called "endothelial-cell-stimulating angiogenesis factor" (ESAF). CBEC growing on plastic culture dishes or denatured collagen films were not stimulated by ESAF. The mitogenic effect of ESAF was equally apparent when added to cells already attached to the native collagen substrate or when the collagen substrate was pre-incubated with ESAF before plating the cells. A floating collagen gel pre-incubated with ESAF in cultures of CBEC growing on plastic dishes did not stimulate cell growth. Our data indicate that the substrate influences cell behaviour and that CBEC only respond to ESAF when growing on a native collagen substrate.

Angiogenesis Inducing Agents↗
PubMed1980

Ultrastructure of Calymmatobacterium granulomatis in Lesions of granuloma inguinale.

Biopsy specimens from the lesions of 14 patients with granuloma inguinale were examined by electron microscopy. Calymmatobacterium granulomatis, the presumed causative agent, was observed within the phagosomes of many macrophages, but only rarely in polymorphonuclear leukocytes. The morphology of the organisms was that of a gram-negative bacteria having a large capsule and no flagella. These morphologic observations are consistent with published findings suggesting that this organism is related antigenically to organisms of the genus Klebsiella.

Calymmatobacterium↗
PubMed1979

Tumour angiogenesis factor (TAF) and its neutralisation by a xenogeneic antiserum.

Tumour angiogenesis factor (TAF) has been extracted from a variety of animal and human tumours. Its ability to induce neovascularization in two bioassays, viz. rat air-sac and chick chorioallantoic membrane, is demonstrated. Similar extracts from normal tissues fail to induce angiogenesis. TAF extracts have been used to raise a xenogeneic antiserum, the specificity of which was investigated using classical immunological methods. Its ability to neutralize the biological activity of TAF using the two in vivo assays, was also demonstrated.

Allantois↗