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Biomedical subjects

P Lynch

Publications and source records attributed to P Lynch.

At least 145 records · Page 8Linked to original sources
PubMed1978

Cutaneous plasmacytomas in myeloma. Relationship to tumor cell burden.

Solitary cutaneous plasmacytomas may occur as benign tumors that are confined to the skin, whereas multiple lesions are generally associated with systemic plasma cell disease. Cutaneous plasmacytomas developed in two patients with documented multiple myeloma; this development occurred late in the course of their disease at a time when their systemic plasma cell tumor burden was large-approximately 3 kg in mass, which represented 2 to 3 x 10(12) cells. The occurrence of cutaneous plasmacytomas in patients with multiple myeloma is generally late in the course of the disease and should be considered as a bad prognostic sign.

Aged↗
PubMed1976

Familial risk and cancer control.

An intensive study of the family history of cancer in 4,515 patients screened consecutively by a multiphasic mobile cancer detection unit showed, after age correction, that cancer had developed in 8.9% of the probands when there was one cancer in a single first-degree relative, 16.2% had cancer with two family members affected, and 27.4% had cancer when three or more family members had been affected. This constituted a significant correlation between family and personal histories of cancer in these patients. Extrapolation to the United States population with cancer-control implications are given.

Age Factors↗
PubMed1976

Coronary angiography with diatrizoate and metrizamide. Comparison of ionic and non-ionic contrast medium effect on coronary blood flow in dogs.

The non-ionic contrast medium metrizamide produced a smaller coronary flow increase than the ionic medium diatrizoate after injection into the main left coronary artery in dogs and had also a shorter transit time through the coronary vessels. The coronary veins were better filled with metrizamide. The reduced coronary flow effects of metrizamide compared to ionic contrast medium and the improved venous filling makes metrizamide a favorable contrast material for use in coronary angiography.

Animals↗
PubMed1975

Breast cancer genetics and cancer control. Tumor association.

Verified breast cancer was present in a father, his mother, and his daughter. His sone had a brain tumor (by history) and his grandson, (ehs sone of the affected daughter), had a histologically verified rhabdomyosarcoma. This familial aggregation of cancers (except for leukemia, which is absent) is consistent with a newly described familial breast cancer syndrome. A single pleiotropic, dominantly transmitted gene, possibly interacting with carcinogenic factors, such as an oncogenic virus, may be the cause. A cancer-control potential exists for tumor associations such as those exhibited in this kindred, as well as for other cancer genetic syndromes where careful consideration is given to all histologic varieties of cancer.

Adolescent↗
PubMed1975

Family studies of malignant melanoma and associated cancer.

This study comprises five cancer prone families with one or more occurrences of melanoma in context with a variety of other histologic types of cancer, including an excess of multiple primary malignant tumors. The genetic mode of transmission of cancer in each family was consistent with a dominant factor which has seemingly predisposed these patients to a general cancer diatheses. The tumor spectrum included malignant melanoma and cancers of the breast, gastrointestinal tract, lung and lymphoproliferative system. Recently, S1 and S2 antigens were noted to occur with malignant melanoma and the same variety of tumors which have occured in these five families.

Adult↗
PubMedDate not supplied

Chest muscle activity and panic anxiety: a preliminary investigation.

This report represents a pilot investigation of the role of chest muscle electromyographic (EMG) activity in developing panic episodes. Chest EMG activity was obtained as part of a larger study examining ventilatory differences between panic sufferers and normal controls. Frontalis EMG, heart rate, and minute ventilation (breathing rate and tidal volume) were also obtained during the study. The ventilatory procedure involved exposing the subjects to three periods of carbon dioxide gas inhalations (1%, 3%, 5%; balance oxygen). Subjective measures of frightening cognitions and body sensations were obtained across the inhalation phases as well. The panic disorder subjects were divided, on the basis of subjective anxiety ratings obtained throughout the study, into high anxious (HA) and low anxious (LA) panic disorder groups. The HA panic disorder patients exhibited significantly higher chest EMG activity than the LA panic disorder patients and controls across all phases of the experiment. In addition, the chest EMG predicted, better than the other physiologic measures, the number of frightening cognitions and sensations reported by the subjects during the baseline and 5% CO2 inhalation phases. Overall, the results were supportive of the further study of chest wall EMG activity in the pathogenesis of panic attacks.

Adult↗
PubMedDate not supplied

Addition of calcium or other cations and of oxygen to ionic and non-ionic contrast media. Effects on cardiac function during coronary arteriography.

Metrizamide is a new non-ionic water soluble contrast agent. Isolated rabbit hearts were perfused with solutions of 1) metrizamide, 2) metrizamide with plasma equivalent amounts of cations, 3) oxygenated metrizamide, 4) oxygenated metrizamide with cations, 5) diatrizoate. Solutions of 1) metrizamide, 2) metrizamide with plasmaequivalent amounts of cations, 3) metrizamide with calcium ions, 4) metrizoate (ionic medium) with calcium ions, metrizoate with 5) low and 6) high sodium content and 7) diatrizoate were injected into the left coronary artery of dog hearts in vivo. Maximal change of myocardial contractile force was measured with a strain gauge arch. Changes in aortic blood pressures were also recorded. In both sets of experiments metrizamede affected these parameters less than the ionic contrast media. The addition of calcium ions to both ionic and non-ionic media reduced the adverse effects on the observed cardiac funcitons, while simultaneous addition of plasma equivalent amounts of four cations as metrizoate salts had no beneficial effects. Sodium ions had in high concentration deleterious effects on cardiac performance. Oxygen saturation of the contrast medium had no observable effect. The adverse effects on cardiac mechanical function of sodium ions and possibly other cations contained in a contrast medium solution might be counterbalanced by the addition of calcium ions to the solution.

Aminoglycosides↗
PubMedDate not supplied

Heart transplantation in neonates and in children.

Between May 1988 and July 1991, 28 neonates and children underwent orthotopic heart transplantation at Children's Memorial Hospital in Chicago. Indications for heart transplantation were hypoplastic left heart syndrome (10), dilated cardiomyopathy (13), aortic stenosis with endocardial fibroelastosis (1), complex D-transposition of the great arteries after Senning repair (1), L-transposition of the great arteries with single ventricle after shunt (1), cor biloculare, pulmonary atresia, and situs inversus after Fontan (1), and chronic rejection after heart transplantation for hypoplastic left heart syndrome (1). The age at time of transplantation ranged from 2 days to 17 years (mean, 5.3 +/- 6.1 years). Early deaths were from intraoperative donor right ventricular failure (2) and acute rejection after a second transplant procedure at 21 days (1), for an in-hospital mortality rate of 10.7%. Immunosuppression was with cyclosporine, azathioprine, and prednisone, with an attempt to discontinue the prednisone in neonates at age 6 months as guided by endomyocardial biopsy. Rejection episodes were treated with methylprednisolone pulse (34) or with OKT3 (4). Endomyocardial biopsy (in patients older than 6 months) was used extensively, and acute rejection was diagnosed in 29 of 301 biopsies. Three late deaths occurred (mean follow-up, 16.3 +/- 11.8 months): one of acute rejection at 13 months, one of viral pneumonia at 7 months, and one of intraabdominal sepsis as a complication of peritoneal dialysis at 5 months. Actuarial survival at 2 years is 77% +/- 9% (standard error of the estimate). Heart transplantation for neonates and for children can be performed with acceptable operative mortality. Intermediate results with triple therapy immunosuppression and an intensive rejection surveillance regimen relying on endomyocardial biopsy are encouraging.

Actuarial Analysis↗