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Biomedical subjects

P Lynch

Publications and source records attributed to P Lynch.

150 records · Page 9Linked to original sources
PubMedDate not supplied

Surgical blood exposures after the OSHA bloodborne pathogens standard: frequency and prevention.

1. Approximately 22.4 million surgical procedures are performed annually in US hospitals. Up to 2,688,000 personnel exposures to blood may occur annually. Punctures would account for 349,940 (13%) of those exposures, and 38,493 patients would have contact with blood from the punctured personnel. 2. Epidemiologists use parameters of time, place, and person to describe situations and identify prevention strategies: who is at increased risk, what devices and activities lead to more frequent exposures, when exposure frequency is greatest, and where blood contact actually occurs. The answers to these questions form the basis for successful prevention; without the correct answers operating rooms either miss the target or spend far too much money preventing low-risk events. 3. OSHA and previous researchers estimated that a substantial portion of blood exposures could be prevented by either changing certain practices such as passing loaded suture holders, or by protective attire such as fluid-resistant gowns.

Blood↗
PubMedDate not supplied

Spectrum of humoral rejection after pediatric heart transplantation.

The deposition of immunoglobulin and complement 3 in the coronary microvasculature (humoral rejection) has been associated with poor outcome after heart transplantation. The purpose of this study is to relate the incidence of immunoglobulin and complement 3 myocardial deposition to the clinical course of pediatric heart transplant patients. One hundred thirty-one biopsy specimens from 30 patients, whose mean age at transplantation was 4.9 years (range, 2 days to 17 years), were processed for light microscopy and immunofluorescence. The mean follow-up was 25 months (range, 6 to 63 months). All patients underwent annual selective coronary artery angiography. No cellular or humoral rejection was seen in 97 biopsy specimens. Humoral rejection without cellular infiltrate was found in eight biopsy specimens from four patients (13%). Of 19 grade 1A, B (mild) biopsy specimens, 17 showed only cellular rejection, and two showed a mixed pattern of cellular and humoral rejection. Of six grade 2,3 (moderate) biopsy specimens, four showed only cellular rejection, and two showed a mixed pattern. The only grade 4 (severe) biopsy specimen revealed a mixed pattern. Three patients have had persistent immunoglobulin M and complement 3 deposits. One of these had angiographic evidence of accelerated graft coronary artery disease 2 years after transplantation, which was later confirmed at autopsy. Coronary artery disease has not been detected by serial angiography at 1 year (28 patients), 2 years (18 patients), 3 years (15 patients), 4 years (five patients), and 5 years (one patient). Humorally mediated rejection occurs with and without cellular rejection after pediatric heart transplantation. Humoral rejection may persist after treatment and resolution of severe cellular rejection episodes.(ABSTRACT TRUNCATED AT 250 WORDS)

Biopsy↗
PubMedDate not supplied

Eye injury and sport: sport-related eye injuries presenting to an eye casualty department throughout 1995.

A survey was undertaken of all patients attending the Eye Casualty Department at Waterford Regional Hospital with sports injuries in the twelve-month period 1st January 1995 to 31st December 1995. Ninety eight patients had problems associated with sport. Hurling was responsible for the largest group (30%) and football of different codes accounted for 29%. The next largest group was the racquet sports (13%). The most common injuries were to the anterior chamber (hyphaema and microhyphaema: 36%). There were three orbital fractures. 26 patients (27%) were admitted. 83 patients (85%) were male. The median age was 20 years. Sport is a significant cause of eye injury, which is often serious, and affects mostly young healthy males.

Adult↗