Search PubMed⌕ Search

Biomedical subjects

P Gerber

Publications and source records attributed to P Gerber.

At least 37 records · Page 2Linked to original sources
PubMed1993

Lymphoproliferative disorders in an IL-7 transgenic mouse line.

A high incidence of severe lymphoproliferative disease was observed in a newly generated strain of mice carrying murine IL-7 as a transgene under the control of the E alpha (MHC class II) promoter. An analysis of the cells from lesions in these mice shows the selective expansion of cells at an early stage of B cell development and, more interestingly, expansion of cells phenotypically identical to the recently reported bipotent (B/macrophage) stem cell populations described in midgestation embryonic liver. Such cells can be propagated (and remain dependent upon) bone marrow feeder cell lines obtained from IL-7 transgenic mice. A molecular analysis of fresh and cultured cells reveals that the lesions are oligoclonal, or in rare cases monoclonal, and include clones of cells with unrearranged Ig heavy chain loci. These data suggest that IL-7 acts at multiple stages of B cell development. Furthermore cell lines derived from IL-7 transgenic mice may provide a novel source of rare factor-dependent bipotent stem cells.

Animals↗
PubMed1990

[Semiautomatic insulin injection equipment (pens)].

To the best of our knowledge, a good glycaemic control must be advised to avoid or delay the degenerative complications of diabetes, bearing in mind an increased risk of hypoglycaemias. Among other techniques, a treatment consisting of multiple injections (basal-bolus concept) is one way to achieve a good control. Although this form of treatment is rather restrictive (frequent blood glucose determinations), the use of pens makes it more acceptable. A fully informed and cooperative patient is a prerequisite before considering this particular type of insulin therapy which, however, is usually not very helpful for older diabetics. It is a misconception to think that every patient receiving insulin should do so with a pen, just as it is incorrect to recommend multiple injections for all type I diabetics. Whether such a therapeutic strategy is indicated should be established for each patient individually. In addition, the fashion for pens should not distract us from all the other problems associated with inadequate diabetic control, such as foot care and systematic blood pressure measurements.

Diabetes Mellitus, Type 1↗
PubMed1990

Symptomatology of late-life minor depression among primary care patients.

Patients of four general internists and four family physicians were interviewed by two psychiatrists to identify those suffering from depressive disorders. Nineteen elderly (60 years of age and older) patients and 22 younger (between 18 and 59 years of age) patients met Research Diagnostic Criteria (RDC) for minor depressive disorder, and 73 elderly and 79 younger patients had no psychiatric disorder. In general, the elderly depressed medical outpatients and the younger depressed medical outpatients had similar symptomatology, as did the elderly and nonelderly medical outpatients without psychiatric disorders.

Adult↗
PubMed1990

[Hydroxylapatite-coated total prosthesis of the hip].

Since 1987, 80 hydroxyapatite-coated (HA) cementless total hip prostheses have been implanted. Thirty patients were examined 21 months postoperatively and the results compared with data for uncoated prosthesis. Earlier mobilization and freedom from pain, together with evidence of bone ingrowth without connective tissue membrane formation, confirmed the benefits of HA-coated prostheses.

Aged↗
PubMed1989

[Mushroom ileus without previous intestinal obstruction].

A case is described of obstruction of the small bowel after consumption of 500 g edible mushrooms (Cantharellus cibarius). No fibrous bands or adhesions were found on laparotomy. When preparing the meal the mushrooms were not cut up, nor were they properly chewed due to the patient's defective dental prosthesis. 11 days after the meal the patient passed largely intact mushrooms. In retrospect the impacted mushrooms could be assumed on X-ray after barium meal. Since even without intra-abdominal adhesions impacted mushrooms can cause mechanical obstruction, it is recommended that mushrooms be cut up, chewed well and consumed only in moderate portions even when large quantities are available.

Adult↗
PubMed1989

[Experimental pancreatic duct occlusion with polyurethane].

Pancreatic transplantation requires an effective method to manage exocrine secretion. A new technique to eliminate the exocrine function of the pancreas by obstruction of the duct with polyurethane was investigated in terms of function, outcome and morphology. Polyurethane is an alcoholic solution of block copolymers with the property of polymerizing within 5-10 min. In this study the in-situ pancreatic tail model in dogs was utilized, the pancreatic duct was cannulated and injected with 2-3 ml of polyurethane. As a result, complete atrophy and fibrosclerosis of the exocrine tissue was obtained leaving islets well vascularized and functioning for the entire experimental periods. All animals remained normoglycemic and showed normal K-values. Amylase levels were found to be maximally elevated at 24 h and returned to normal within 2 weeks after duct occlusion. Insulin, glucagon and somatostatin levels remained normal. Because of its ability to effect a complete occlusion of the pancreatic ducts with subsequent atrophy of the exocrine gland and without notable disturbance of endocrine function, we feel that polyurethane solution is superior to previously used materials for this purpose.

Animals↗
PubMed1988

Hotson's syndrome--the "all-or-nothing" rule.

Whenever a plaintiff has lost a chance of a better medical result, which might have been achieved by prompt diagnosis and correct treatment, he or she must recover 100% of the award of damages provided that the plaintiff can prove that he or she had a better than 50% chance of an improved result.

Australia↗