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Biomedical subjects

P Gerber

Publications and source records attributed to P Gerber.

At least 55 records · Page 3Linked to original sources
PubMed1988

The enhancer in an MHC class II gene, in vitro and in mouso.

The E alpha class II gene of the major histocompatibility complex is expressed in a variety of immunocompetent cells. Part of the control of tissue-specific expression is mediated by a block of sequences found far upstream of the transcriptional startsite; this stretch is necessary for expression in the B lymphocytes of transgenic mice, but largely dispensable elsewhere. We review the evidence for the role of this region in E alpha transcription in transgenic animals, as well as data from transfections into tissue-culture cells, which indicate that this region has non-specific enhancer activity. We discuss possible models to explain how a non-specific enhancer can participate in cell-specific control.

Animals↗
PubMed1987

Vasectomies are legal--even in Queensland.

Consent by patients to voluntary sterilization frees surgeons from criminal responsibility for assault when such consent is given freely with the knowledge of the purpose and consequence of the procedure, and when the operation is performed with professional skill. However, it is considered unethical for surgeons to sterilize a married man or woman of child-bearing age unless they have satisfied themselves that the other party to the marriage has consented to the procedure.

Australia↗
PubMed1987

Psychiatric symptoms in the elderly in a primary care practice.

During a 15-month period in a rural group medical practice 1063 patients of four general internists completed a 49-item version of the Hopkins Symptom Check List (HSCL). This version of the HSCL measured symptoms of depression, anxiety, phobic anxiety, hostility, and interpersonal sensitivity. In comparison to younger groups, the elderly patients reported decreased symptomatology on all HSCL scales except the phobic anxiety scale. These differences could be due to a reporting effect, selective migration or mortality, a cohort effect, or they could reflect a true age effect, the view favored by the authors.

Aged↗
PubMed1986

Medical negligence and legal causation--where the twain do not meet.

Medical neglect is legally irrelevant where it can be shown that it did not cause the harm that is the source of the complaint. On the other hand, there are problems with causation and quantum where the failure to apply appropriate care has the consequence of depriving the plaintiff of the chance of a better medical result.

Australia↗
PubMed1986

[Experimental studies of the significance and mechanism of desensitization to the gonadotropin-inhibiting effect of estrogen. 2. Detection and mechanisms of preovulatory desensitization in the ovarian cycle].

It has recently been demonstrated in women and several mammalian species that the basal LH secretion increases prior to the ovulation-inducing LH surge in spite of a simultaneous rise of the estrogen level in the blood. The temporary relative inefficiency of estrogen in its negative feedback action may be necessary to make adequate gonadotrophic support of final preovulatory follicle maturation possible. To study the mechanisms underlying this phenomenon, the gonadotrophic response to a single injection of estradiol benzoate (EB) was evaluated in acutely ovariectomized adult rats during the different stages of a 4-day ovarian cycle. The results showed that the sensitivity to the gonadotrophin-inhibiting effect of EB is high during late estrus and early metestrus. Between metestrus and diestrus it suddenly declines, and EB did not inhibit the hypophysial gonadotrophin secretion from diestrus through the morning of the subsequent estrus. The cyclic variation of the sensitivity to the negative estrogen feedback is probably not based upon an endogenous rhythm that is independent of the ovarian hormone secretion, because similar variability of the gonadotrophic response to estrogen was not found in rats that had been castrated three days before the injection of EB. A further experiment demonstrated that bilateral implants of EB placed in the medial preoptic area (MPOA) of ovariectomized rats significantly reduced the gonadotrophin-inhibiting effect of s. c. injected estradiol, whereas similar implants located in the mediobasal hypothalamus were completely ineffective in this regard. Since bilateral lesioning of the MPOA in long-term ovariectomized females also lowered the sensitivity to estrogen, the conclusion may be drawn that preovulatory desensitization to the negative estrogen feedback is probably induced in cyclic female rats by an inhibitory effect on medial preoptic neurones of the increase of circulating estrogen recorded in metestrus. In accordance with this assumption, imitation of the periovulatory diminution of estrogen action on the MPOA of intact rats by the removal of medial preoptic EB implants in castrated females during the afternoon of proestrus, resulted in high sensitivity to estrogen during estrus and metestrus. The possible clinical significance of the hitherto not described preovulatory desensitization is briefly discussed.

Animals↗