Search PubMed⌕ Search

Biomedical subjects

P David

Publications and source records attributed to P David.

At least 181 records · Page 10Linked to original sources
PubMed1982

Factors predicting working status after aortocoronary bypass surgery.

The working status of 1165 patients aged 59 years or less (mean 49.8 years) was evaluated 7 to 77 months (mean 36 months) after aortocoronary bypass surgery. Although 76% of the patients eventually returned to work, only 56% were working 6 months after their operation. The proportion of patients working peaked at 2 years after the operation (at 66%) and decreased progressively to 56% at 4 years and 53% at 5 years without ever reaching the proportions that applied 12 and 6 months before the operation (84% and 69% respectively). Multivariate analysis identified three socioeconomic and three clinical variables as predicting the working status at 6 months and at yearly points during the first 4 years after the operation. Of the socioeconomic variables analysed, preoperative unemployment of long duration, a preoperative occupation that required strenuous physical effort and a low level of education were, in that order, the strongest predictors of postoperative unemployment. Among the clinical variables, associated noncardiovascular illness and the severity and duration of angina pectoris independently influenced the patients' post-operative working status. The authors conclude that modification of some of these variables should by attempted both before and after aortocoronary bypass surgery to see whether the rate of return to employment after the operation can be improved in selected patients.

Adult↗
PubMed1982

When is there a full recovery for a myasthenia gravis patient?

A myasthenia gravis (MG) patient who seems to have recovered can later have recurrence of myasthenic signs. Clearly clinical remission does not always correspond to the normalization of all the factors involved in the pathogenesis of the disease. In ten patients who had apparently recovered from MG, electromyographic tests of repetitive supramaximal stimulation were performed and the anti-acetylcholine receptor (anti-AChR) antibody was assessed. In two of the ten patients all these tests were normal, thus showing lack of electromyographic myasthenic fatigability and the absence of circulating anti-AChR antibodies. Our hypothesis is that for these two subjects the risk of a recurrence of MG is lower than for the others.

Adolescent↗
PubMed1982

Employment following aortocoronary bypass surgery in young patients.

The work status following aortocoronary bypass surgery was evaluated by questionnaire in 268 male patients aged 44 years or less, after a mean follow-up of 38 months. During follow-up, 87% resumed work; when analyzed on a yearly basis, the rate of patients at work peaked at 2 years (80%) and then declined to 70% at 4 years. Multivariate analyses showed that the two most important preoperative variables predictive of work status after surgery were (1) the length of the period of not working, and (2) the educational level. Other influential factors were the presence of an associated vascular disease and the type of work, annual income and functional class. The postoperative health status, as described by the patient, was also closely correlated with return to work. Recurrence of angina after surgery impaired work resumption. A majority of patients who were never gainfully employed after surgery attributed the reason to their physician, while 93% of them stated that they received financial aid from the government.

Adult↗
PubMed1982

[Two-dimensional echocardiography in subvalvular aortic stenosis. Apropos of 20 cases].

Twenty cases of discrete subvalvular aortic stenosis in children aged from 8 months to 23 years were examined by 2-dimensional echocardiography and cineangiography. Fifteen of these patients subsequently underwent open heart surgery to relieve the obstruction. In 18 cases the obstacle was a fixed stenosis (13 type I, 3 type II and 2 type III) and in two cases, the obstacle was provoked by accessory tissues of the anterior mitral leaflet. The echocardiographic incidences used were the left parasternal long axis, the apical LAO-equivalent, and longitudinal and transverse subcostal views. In type I, fixed subvalvular stenosis, one fine abnormal echo was visualised in the left ventricular outflow tract throughout the cardiac cycle immediately below the aortic valve, best seen on apical views. Twelve of the 13 stenoses of this type were demonstrated by 2D echocardiography. In type II stenosis an abnormal thickened echo was visualised in the left ventricular outflow tract at a distance from the aortic cups. The adherence of this abnormal echo to the anterior mitral leaflet was best demonstrated by apical views. All three cases of this type were demonstrated by echocardiography. Type III stenosis was characterised by widespread narrowing of the subaortic region with irregular borders. Obstruction due to accessory tissues of the anterior mitral leaflet were well demonstrated in left parasternal long axis and apical views. They showed an even rounded mass of echos attached to the anterior aspect of the anterior leaflet prolapsing into the left ventricular outflow tract. Both cases in this series were diagnosed by 2D echocardiography. Therefore, 2D echocardiography with apical and subcostal views is a valuable method for diagnosing subvalvular aortic stenosis and for determining its anatomical type.

Adolescent↗
PubMed1981

[Presence of lymph-vascular anatomical units in dermoid cysts and the probable existence of a local immune defense system in various tissues].

Studies on tooth eruption in several ovarian dermoïd cysts showing the existence of immune defense gingival structures has allowed the presence of similar structures associated with respiratory and digestive differentiation zones to be observed. These structures are formed of histiocyto-plasmocyto-lymphocytes associated with capillary loops. The origin and histogenesis of those structures remains to be clarified but they suggest the probable existence of localised immune defense systems within certain tissues.

Cell Differentiation↗
PubMed1981

Clinical features of amyotrophic amyotrophic lateral sclerosis.

The clinical features and course of amyotrophic lateral sclerosis are discussed. The data on a series of 116 patients are compared with those of the literature. The following points emerge: 1) when the disease starts before the age of 50, the prognosis is often less poor than usual; 2) the forms with spinal, and especially cervical, onset appear to be less rapid than bulbar forms; 3) in 20% of the patients survival is over 5 years. There may be some unknown factor that increases the resistance of some subject to the disease.

Adult↗
PubMed1981

[Small-caliber vascular prosthesis].

Further research on biomaterials should permit the development of an adequate microarterial prosthesis. This program should also allow improvements of the presently available arterial substitutes. Various types of conduits have been tested on an experimental model: prosthetic tube, biological conduits either preserved or chemically modified. The most encouraging results have been observed with an arterial conduit, prepared from fresh aorta, treated by trypsin and glycosaminoglycans.

Animals↗