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Biomedical subjects

P David

Publications and source records attributed to P David.

At least 199 records · Page 11Linked to original sources
PubMed1981

[Diagnosis and localization of ventricular septal defects by two-dimensional echocardiography. 50 cases].

A series of 50 children aged between 1 month and 15 years old, with ventricular septal defects (VSD) were investigated by two-dimensional sector scanning and cineangiography. Fifty other children of the same age group with congenital heart disease without VSD were also investigated by two-dimensional echocardiography and angiography. No VSDs were diagnosed by echocardiography in children with angiographically intact inter ventricular septa. In the group with VSD, two-dimensional echo localised with precision: --36 membranous VSDs (36/36) --5 infundibular VSDs (5/6) --2 isolated muscular VSDs (2/2) --I atrioventricular canal type VAD (I/I) --3 multiple VSDs (3/5). The subcostal view was the most useful for visualising the VSD in 49 out of 50 cases. The parasternal views only showed the VSD in 23 cases, and the apical views only in II cases. The dimensions of the left heart chambers and the movement of the interatrial septum gave an indication of the volume of the left-to-right shunt. Dilatation of the left heart chambers and bowing of the interatrial septum into the right atrium in systole were observed in all cases where QP/QS greater than 2, except when there was an associated atrial septal defect. Two-dimensional echo also detected associated lesions: pulmonary stenosis (9/9), prolapse of an aortic valve cusp (4/5), atrial septal defect (2/2), stradling of the tricuspid valve (I/2). Two-dimensional echocardiographic short axis subcostal views are reliable in the detection and localisation of VSD. Nevertheless, trabecular and apical VSDs are particularly difficult to visualise and the use of pulsed Doppler coupled with two-dimensional echocardiography should enhance the sensitivity in diagnosing this type of VSD.

Adolescent↗
PubMed1981

[Diagnosis of a complete atrioventricular canal with infundibular pulmonary stenosis and left superior vena cava by 2-dimensional contrast echocardiography. Apropos of a surgically treated case].

The case of an eight year old child with complete atrioventricular canal, pulmonary infundibular stenosis and persistent left superior vena cava draining into the coronary sinus is reported. Two-dimensional echocardiography with injection of contrast in a left arm vein gave a precise and complete diagnosis of the malformations before catheterisation and angiography. The complete atrioventricular canal was demonstrated by apical four-chamber views. The pulmonary infundibular stenosis was visualised by a short axis subcostal view. Contrast echocardiography in the apical four-chamber view showed a right-to-left shunt at atrial level at the site of the ostium primum and a right-to-left shunt at ventricular level just below the hemivalve. The left superior vena cava was detected by a short axis suprasternal view which visualised its vertical trajectory as far as the coronary sinus. The lesions were confirmed at surgery, and a complete repair was performed.

Atrioventricular Node↗
PubMed1981

[Use of thyrocalcitonin by the trans-dentinopulpal route as a means of stabilizing and preventing rejection of human teeth homografts. Results and radiological changes (author's transl)].

Clinical and radiological results of an antirejection therapy based on the local action of a thyroid hormone, thyrocalcitonin, were studied. A double action was noted as it may stop the rhyzalase, and, more particularly, it reestablishes normal alveolodental relationships. Immunological factors are discussed. The therapeutic mode of action is emphasized as being a new method of local treatment.

Calcitonin↗
PubMed1980

[Simple cholecystectomy without drainage. A dilemma?].

A retrospective study was carried out to show the uselessness of the routine employment of the drainage after simple cholecystectomy. 1425 patients underwent cholecystectomy because for cholelithiasis; of these 164 (13%) were drained because of adhesions, concomitant pancreatitis, inadvertent damage, empiema, gangrena and perforation of the gallbladder. In no case of the 1261 patients without drainage it has been possible to demonstrate the presence of one of those complications for which the use of a drainage after simple cholecystectomy is commonly advised.

Cholecystectomy↗
PubMed1980

Cholecystectomy without drainage: a dilemma?

A retrospective study was carried out to show the uselessness of routine drainage after simple cholecystectomy. Cholecystectomy was performed in 1,425 patients with cholelithiasis; 164 (13 percent) were drained because of adhesions, concomitant pancreatitis, inadvertent injury, gangrene, empyema and perforation of the gallbladder. None of the complications for which the use of drainage after simple cholecystectomy is commonly advised were observed in any of the 1,261 patients without drainage.

Cholecystectomy↗
PubMed1980

Cephalic and noncephalic references in brain stem-evoked potential recording.

55 controls were studied to investigate the morphology of brain stem evoked potential, utilizing variable electrode arrays. In a first series the active electrodes placed at Cz and subocciput (SO) were referred to the linked earlobes. In a further 15 recording sessions, Cz, SO and A1A2 were connected to a noncephalic (hand) electrode. In the former array there was a reversed and depressed Vth wave in 95% of the cases at SO, while in the latter the peaks were phase and time-locked at all the recording sites coupled to a depressed IV-V complex from SO and A1A2 in respect to Cz.

Acoustic Stimulation↗
PubMed1980

[Changes in work status in a French-Canadian population after aorto-coronary bypass surgery].

Work status after aortocoronary bypass surgery was evaluated in 1 320 male patients who were less than 60 years old at the time of their operation. The percentage of working patients is maximal two years after surgery (66.5 p. 100) and decreases gradually (53 p. 100) at five years. This percentage remains lower than the 84 p. 100 and 69 p. 100 which were observed twelve and six months before the operation. Multivariate analyses showed that the length of the period of pre-operative inactivity had a preponderant role in predicting work status after surgery. The second best predictor was the type of work in patients aged 45 or more and the educational level in younger patients. All other variables-duration of illness, functional class, other illness, postoperative complications, marital status, annual income, age-had a lesser role. Variables predictive of continued employment (greater than or equal to 2 ans) after surgery were similar. Univariate analyses on postoperative factors showed a negative correlation between recurrence of angina and return to work. A majority of patients who never returned to work after surgery kept a stable income (65.5 p. 100) and 83 p. 100 of them received financial aid from the government.

Coronary Artery Bypass↗
PubMed1980

[Indirect and direct indicators of pulp repair of human homografts. Preliminary studies of histoclinical correlation (author's transl)].

A clinical experimental study involving human grafts (heterochronic and heterogenic homografts) was carried out after different techniques (isolation, preservation, decontamination, freezing-thawing cycles of grafts). Surgical application then the clinical and radiological course were followed up over a period of up to 4 years. Some pulp specimens were examined histologically. Clinical, radiological and histological correlation was envisaged in order to offer hypotheses, in particular immunological, with regard to the course of the process.

Dental Pulp↗
PubMed1980

Mass production of insect cells in suspension.

The production of insect pathogenic viruses for the use in integrated pest control is presently done in vivo in populations of their natural hosts. However, efforts are made in several laboratories to produce some of these baculoviruses in insect cell cultures. The mass production of the viruses in vitro depends on a technology for the mass production of cells. Data are presented for the production of up to 10(10) insect cells per logarithmic growth phase in a continuously running fermenter culture at volumes of 9-10 litres.

Animals↗
PubMed1979

[Interpretation of the gingival inflammatory infiltrate].

The investigation of tooth eruption in dermoid cysts of the ovary allows one to observe in the chorion at the level of the epithelial attachment, an anatomical component that seems to correspond to a local system of defense. Up until now this has been considered to be a secondary inflammatory response resulting from the bacterial or mechanical assault. This component is found to form when the tooth erupts and constitutes an important element in the physico-pathogical process and of the immune response of the dental organ.

Animals↗
PubMed1979

Treatment of myasthenia gravis. Report on 139 patients.

In the treatment of myasthenia gravis (MG) considerable progress has recently been achieved. Our experience is based on the observation of 139 patients with an average follow-up of 3 years and 4 months. A treatment plan and results are presented. Indications for thymectomy: all cases of MG in adult life, apart from ocular myasthenia without radiological thymoma and without electrophysiological and pharmacological signs of generalization; before puberty only cases with radiological thymoma and severely incapacitating or life-threatening signs. Median sternotomy is preferable for thymoma, the transcervical approach with a sternal split for non-neoplastic thymus. Mediastinal radiotherapy is indicated after removal of an invasive or adhesive thymoma. Indications for corticosteroids: 1) before thymectomy: respiratory weakness; 2) soon after thymectomy: life-threatening signs; 3) later after thymectomy: incapacitating or life-threatening signs; 4) as an alternative to thymectomy: when surgery cannot be performed or it is not indicated. Oral Prednisone was nearly always preferred: alternate-day high single dose (75 to 115 mg) has given good results in most cases even if in some cases a small dose was required in the "off day"; inversely a lower alternate-day or daily dose was often sufficient. Long-term results: following this schedule for adult patients good results were scored in 67% of thymomas, in 94% of hyperplasias, and in 62% of unthymectomized patients: in prepuberal life the few cases of severe MG have all shown a favorable evolution.

Adrenal Cortex Hormones↗
PubMed1979

Jakob-Creutzfeldt disease: analysis of EEG and evoked potentials under basal conditions and neuroactive drugs.

EEG and evoked potential (EP) recordings of a female (aged 70) affected with Jakob-Creutzfeldt disease (JCD) are reported. A comparison of neurophysiological tests under basal conditions and pharmacological stimulation with methylphenidate, diazepam and piracetam was performed. Diazepam and methylphenidate produced a flattening of triphasic complexes and changes in background activity; piracetam did not seem to influence the abnormal brain bioelectrical environment. The authors conclude that EEG and EP abnormalities in JCD can be ascribed to two separate and interacting sources: (1) exaggerated massive excitatory input coming from a deep thalamic pace-maker throughout the diffuse projecting system, and (2) lack of inhibitory intracortical mechanisms.

Aged↗
PubMed1979

Effects of amiodarone on cardiac and coronary hemodynamics and on myocardial metabolism in patients with coronary artery disease.

While the antiarrhythmic effects of amiodarone are well-documented, its hemodynamic effects are not. We injected 5 mg/kg amiodarone i.v. in 16 patients undergoing coronary arteriography. Heart rate did not change. Aortic (systolic, diastolic and mean) and left ventricular (systolic and end-diastolic) pressures decreased significantly (p less than 0.01) at 5 and 15 minutes; systemic vascular resistance also fell significantly (p less than 0.05), while cardiac index increased slightly but significantly (p less than 0.05). Coronary vascular resistance decreased significantly (p less than 0.01) and coronary sinus blood flow rose in most patients, from a mean of 138 ml/min to 153 ml/min at 5 minutes (p less than 0.02); it then returned toward the control value at 15 minutes (mean 145 ml/min). Myocardial metabolism of O2 was normal and unchanged. Metabolism of lactate improved in five patients, remained unchanged in seven and deteriorated transiently in four. No undesirable hemodynamic and clinical side effects occurred when the drug was administered slowly. We conclude that amiodarone is a powerful systemic and coronary vasodilator. In addition to its present indications in the treatment of angina pectoris and arrhythmias, the drug might be very useful as an afterload-reducing agent.

Adult↗