[Regulation of immune processes by peptides of natural origin].
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Adjuvants, Immunologic↗
Biomedical subjects
N N Besednova
Publications and source records attributed to N N Besednova.
[Feasibility of decreasing the adhesive activity of Corynebacterium diphtheriae by biopolymers of natural origin].
Possible decreasing of the Corynebacterium diphtheriae adhesive activity by natural biopolymers was studied. It was shown that the strains of C.diphtheriae circulating on the Primorye Territory had middle, low or minimal adhesive activity. Natural biopolymers were found to decrease the adhesive properties of C.diphtheriae. The results of the study are promising for further investigation of natural biopolymers as agents preventing C.diphtheriae colonization on the stomatopharynx mucosa.
Bacterial Adhesion↗
[Effect of immunomodulators of varying nature on the expression of lymphocyte markers in melanoma patients].
The influence of immunomodulators such as tactivin, thymalin, gangliin and translam on expression of lymphocyte markers in patients with melanoma was studied. It was shown in vitro that sensitivity of the lymphocyte receptors of melanoma patients to the immunomodulators was individual and depended on the initial level of the marker expression and the drug properties. Preliminary determination of sensitivity of the immunoregulatory cells to the immunomodulators lays the basis for the use of adequate immunocorrecting therapy in the complex treatment of oncologic patients. Gangliin and translam are membrane active compounds influencing the structure and function of lymphocytic membranes. They are considered as a promising class of immunomodulators with diverse spectra of immunotropic action and various fields of practical use.
Adjuvants, Immunologic↗
[The immunotropic properties of the deoxyribonucleic acid from Salmonidae milt].
The study of the immunotropic action of DNA from salmon milt showed that it increased the antiinfectious resistance of mice to Escherichia coli and Salmonella enteritidis, stimulated the antibody response to the thymus-dependent corpuscular antigen (sheep erythrocytes), increased the production of the antibody forming cells (AFC) in the murine spleen and intensified the absorptive and digestive activities of the cells of the mononuclear phagocytes. The immunotropic properties of the DNA permitted to broaden the DNA application spectrum with its supplementing by immunodeficiency of various genesis and diseases with phagocytic protection mechanisms. It is quite possible that the salmon milt DNA be used as a food additive.
Animals↗
[Interferon-inducing action of polysaccharide-containing biopolymers from ginseng root and cell culture].
Induction of interferon (IF) and tumor necrosis factor (TNF) under the action of two polysaccharide preparations of ginseng i.e. panaxan-1 (from ginseng root) and panaxan-2 (from ginseng cell culture) was studied. Both the preparations induced production of TNF and IF in human leukocytes. By its properties and the typing results the induced IF proved to be gamma-IF. The preparation from the ginseng cell culture in the doses used had a higher IF inducing activity which could be explained by the difference in the polysaccharide composition of the preparations.
Biopolymers↗
[Immunotropic effect of non-laser monochromatic irradiation].
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Animals↗
[Effectiveness of peroral application of a new immunocorrective agent of natural origin].
Data on peroral application of new peptide origin immunocorrector from nervous tissue of hydrobionts are cited. It has been established that immunological gangliin activity, perorally introduced, is close to that being applied parenterally. This drug comprises a soft immunocorrector that is expressed by humoral and cellular factor strengthening of immunity, increasing induces of phagocynosis of PMNC and sells SMPh. Peroral gangliin introduction protects 50-60% of mice from fatal coli-infection. Gangliin availability to be taken perorally opens the door to its wide application as food addition.
Adjuvants, Immunologic↗
[Therapeutic-prophylactic milk products with a new immunocorrector of natural origin].
Authors had received and investigated on experiment milk medical and prophylactic products (milk and kefir) with addition peptide, obtained from nervous tissue of squids. It has been established that addition of gangliin to the milk and kefir causes stimulation cellular and humoral factors of immunity answer at laboratory animals. Medical and prophylactic milk products with gangliin return to the normal state reduced immunity indexes of the mice with experimental immunodeficits.
Adjuvants, Immunologic↗
[Effect of a peptide from the mollusk optical ganglia on macrophage functional activity].
Gangliin (tinrostim), a novel peptide isolated from the nervous tissue of the food mollusks, was investigated with respect to its effect on the cells of the system of the mononuclear phagocytes. It was shown to have a high protective action in some experimental infections. One of the main mechanisms of the gangliin action was the increase of the functional activity of the cells of the system of the mononuclear phagocytes. It was demonstrated that gangliin induced a decrease in the activity of 5'-nucleotidase and increased the absorption and digestive functions of the macrophage.
Animals↗
[Comparative study of the antimicrobial activity of pefloxacin, ciprofloxacin, norfloxacin and azithromycin with respect to Strains of Yersinia pseudotuberculosis].
Ciprofloxacin (C), pefloxacin (P) and norfloxacin (N) had a marked effect on Yersinia pseudotuberculosis strains isolated from the infected humans and animals. The activity of C (MIC 0.0312-0.125 microgram/ml) was higher than that of P and N (MIC 0.0625-2.0 micrograms/ml). The isolates were resistant to azithromycin (MIC 3.1-100 micrograms/ml). The susceptibility of the strains did not depend on the source of their isolation. The polyresistant strains carrying the R plasmids preserved the susceptibility to the fluoroquinolones.
Animals↗
[A new therapeutic-prophylactic product with an immunomodulating additive].
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Adjuvants, Immunologic↗
[Elimination of virulence plasmids of Yersinia pseudotuberculosis as affected by fluoroquinolones].
Pefloxacin, ciprofloxacin and norfloxacin were shown to induce elimination of the virulence plasmids in the strains of Y. pseudotuberculosis. Pefloxacin had a more pronounced eliminating effect than ciprofloxacin and norfloxacin. The elimination of the virulence plasmids with the molecular weight of 40-50 MD in the strains of Y. pseudotuberculosis was more frequent at the subinhibitory concentrations of the fluoroquinolones or at 1/4 of the fluoroquinolone MIC., At 1/8 of the MIC it was rarer. The virulence plasmid elimination in the strains was observed in spite of their serovar but was more frequent in the serovar 1B strains.
Anti-Infective Agents↗
[Antibacterial and immunomodulating activity of fucoidan].
The experimental data on the study of the antibacterial and immunomodulating activity of phucoidan, a sulfatated polymer from brown algae (phucan sulfate), were generalized and it was shown that phucoidan was able to markedly inhibit the growth of gramnegative and grampositive organisms and to stimulate immunoreactions of the humoral and cellular types, as well as phagocytosis. The possible use of phucoidan as a drug with associated antibacterial and immunomodulating activity is discussed.
Adjuvants, Immunologic↗
[Sensitivity of Yersinia pseudotuberculosis to pefloxacin].
Pefloxacin susceptibility of 27 Yersinia pseudo-tuberculosis isolates from the infected humans and animals (serovars 1a and 1b with different plasmid spectra) was studied by the method of two-fold serial dilutions in the liquid medium. The culture was incubated at a temperature of 37 degrees C for 48 hours. It was shown that all the isolates were highly susceptible to the antibiotic. The MIC was 0.0625-1.0 microgram/ml and did not depend on the source of the strain isolation.
Animals↗
[Combined action of doxycycline and mytilan on the immune response to tularemia antigen].
Combined action of doxycycline and mytilan, a natural polysaccharide, on the primary immune response to the antigen of the tularemia vaccinal strain in CBA mice was studied. The polysaccharide was used to compensate the immunosuppressive effect of doxycycline high doses on the humoral immune response. The maximum stimulation of the antibody titers as compared to the controls (more than 250 per cent) was observed when mytilan was administered simultaneously with or prophylactically 3 days prior to the antibiotic in doses of 2.5 and 25 mg/kg. The use of mytilan in combination with doxycycline high doses made it possible to compensate the antibiotic-induced decrease of DTH and even to stimulate it as compared to the controls. The highest levels of DTH (150 per cent against the control) were observed when mytilan was administered prophylactically in doses of 2.5 and 11.25 mg/kg 3 days prior to immunization. Mytilan had the highest stimulating effect on antibody production. The combined use of doxycycline and mytilan was characterized by significant stimulation of antibody production and DTH when the dose/time regimens were rational.
Animals↗
[Effect of mytilane, a bioglycan from the mussel Crenomytilus grayanus, on the course and outcome of experimental flu infection].
Materials characterizing the antiviral activity of Mytilane, manifested by the protection of 50-60% of mice infected with the lethal dose of influenza virus and by a decrease in the severity of pathological changes in the lungs of mice, are presented. The inhibiting activity of Mytilane with respect to the reproduction of influenza virus in vivo and in vitro under experimental conditions is demonstrated.
Adjuvants, Immunologic↗
[Immunomodulating properties of pectin from seawater grass Zostera].
Immunomodulating activity of zosterin was studied. Zosterin is a pectin from sea grass belonging to Zostera with pronounced antibacterial activity and therapeutic efficacy in experimental infections. It was shown that parenteral administration of the drug 24 hours before the antigenic irritation stimulated the humoral and cellular immunity in F1 (CBA X C 57 BL/6) mice: an increase in the number of the antibody cells in the spleen, the DTH and the index of the splenocyte spontaneous proliferation. In the animals treated with injections of zosterin and infected intraperitoneally with a virulent strain of S. enteritidis there was observed a marked increase in migration of polymorphonuclear leukocytes to the abdominal cavity accompanied by an increase in their phagocytic activity. The results suggested the possible use of zosterin as a drug with associated antibacterial and immunomodulating activities.
Adjuvants, Immunologic↗
[Antibacterial and therapeutic effectiveness of a pectin from sea grass Zostera].
The kinetics of the antibacterial activity of zosterin, a polysaccharide preparation of a sea grass belonging to Zoster, was studied. By its chemical structure zosterin is a low ++methoxylated pectin. In vitro the preparation markedly inhibited the growth of ++Gram-negative and ++Gram-positive organisms: S. aureus, E. coli, Y. pseudotuberculosis, S. typhimurium and Ps. aeruginosa. On a model of experimental pseudotuberculosis++ infection caused by oral contamination of mice F1 (CBA X C57B1) with a suspension of Y. pseudotuberculosis zosterin was shown to have a therapeutic effect. It protected 30 to 40 per cent of the animals when administered per os simultaneously with or 24 hours after the contamination. The results are in favour of the zosterin further investigation as a preparation useful in prevention of intestinal infections in persons being in contact with the patients.
Animals↗