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Biomedical subjects

N Moriyama

Publications and source records attributed to N Moriyama.

At least 271 records · Page 15Linked to original sources
PubMed1984

A morphometric study on the ultrastructure of well-differentiated tumours and inflammatory mucosa of the human urinary bladder.

Transmission (TEM) and scanning electron microscopic (SEM) observations were performed on well-differentiated tumours and chronic cystitis in the human urinary bladder. SEM showed that the pleomorphic microvilli were present not only on the luminal surface of the tumour but also on the surface of inflammatory mucosa. The ultrastructure of six tumours and 5 cases of chronic cystitis was evaluated morphometrically. Bladder tumour and inflammatory mucosa were divided into several layers, namely outermost cells (S), subsurface cells just beneath these (S1), subsurface cells of 2 or 3 layers below (S23), intermediate cells of 2 or 3 layers above the basal cells (I23), intermediate cells just above the basal cells (I1) and basal cells (Ba). Areas of nucleus, cytoplasm and cytoplasmic organelles, numbers of nucleoli, nuclear bodies, mitochondria and lysosomes together with irregularity of the cell and nucleus were estimated according to the methods of Weibel. A multivariate analysis of variance on these variables showed that the above subdivision of layers was necessary for the comparison of tumour and inflammation. Discriminant analysis showed various differences between tumour and inflammatory mucosa. The results indicated that the Ba layer is the most effective site for differentiating the tumour from inflammation. Ba cells with large and irregular cytoplasm with an enlarged Golgi area, accompanied by many vacuolar structures, may be indicative of tumour rather than inflammation.

Cell Nucleus↗
PubMed1984

Effect of anticancer drugs on renal neoplasm induced with xenotropic pseudotype kirsten murine sarcoma virus.

The sensitivity of a renal neoplasm induced in vivo with C type RNA virus to anticancer drugs was evaluated. The proliferation rate of the virus induced neoplasm cells depended on the concentrations of antimetabolites, alkylates and antibiotics, but not depends on that of alkaloids. An inhibitory effect of drugs on the virus induced neoplasm cells became evident in the following order, i.e., antimetabolites, alkylates, antibiotics and then alkaloids.

Animals↗
PubMed1984

Hepatic arterial embolization for hepatocellular carcinoma. Comparison of CT scans and resected specimens.

Transcatheter hepatic arterial embolization (THAE) was performed in 18 patients with hepatocellular carcinoma (HCC) and the final CT scans (with and without contrast enhancement) compared with the resected specimen after a short interval (9.8 days +/- 9.9 S.D.). The necrotic area observed histologically corresponded closely to the constant low-density area seen on the CT scan (r = 0.959) in all but 2 cases. The authors conclude that CT closely reflects gross anatomical changes and is useful in assessing THAE as well as deciding if and when embolization should be repeated, especially in patients with negative serum alpha-fetoprotein.

Aged↗
PubMed1984

Splenic infarction, a complication of transcatheter hepatic arterial embolization for liver malignancies.

Splenic infarction was recognized in five of 37 patients who had hepatic neoplasms and who were being examined after transcatheter hepatic arterial embolization by CT during a follow-up study. CT images of the spleen showed multiple low density areas of a wedge or fused-wedge shape in most patients and of a rod or round shape in others. These low density areas decreased in size in time, and in two patients they disappeared in three months. Three of the five patients complained of a dull pain in the left upper quadrant that did not require any treatment. CT is effective in the diagnosis and assessment of splenic infarction. Awareness of this complication will help to avoid it when hepatic arterial embolization is being performed.

Adult↗
PubMed1984

Primary Budd-Chiari syndrome: ultrasonic demonstration.

Three cases of primary Budd-Chiari syndrome were found by ultrasonic examination. These were confirmed by hepatic venography and inferior vena cavography. The ultrasound findings in these patients included communicating vessels between hepatic veins, enlarged inferior right hepatic vein, reversed blood flow in the hepatic vein, and obstruction of the inferior vena cava. With these findings, ultrasound can be used to diagnose primary Budd-Chiari syndrome without hepatic venography or inferior cavography.

Aged↗
PubMed1984

Sonographic detection of large spontaneous spleno-renal shunts and its clinical significance.

The ultrasonographic findings of large spleno-renal shunts seen in five patients with liver cirrhosis and confirmed by CT and/or portography, are described. These spleno-renal shunts were seen in the left inter- or subcostal sections as transonic, mass-like lesions located between the splenic hilum and the left kidney, and by continuous scanning, they were found to be part of a tortuous, large tubular structure. Oesophageal varices were absent or minimal in these patients, and none of them had ever bled.

Aged↗
PubMed1983

Effect of hyperthermic vesical irrigation with bleomycin on the ultrastructure of the well-differentiated tumour and non-tumorous mucosa of the human urinary bladder.

Bladder tumours and non-tumorous bladder mucosa were studied by scanning and transmission electron microscopy in seven patients who had undergone hyperthermic vesical irrigation with bleomycin. The treatment induced sloughing of the outermost tumour cells, an increase of blebs and a decrease of cytoplasmic processes of the deeply located tumour cells as well as cellular degeneration. Although less severe, non-tumorous mucosa showed similar changes. Microvilli also appeared on the superficial cells of non-tumorous mucosa after the treatment. This treatment is effective by inducing cell degeneration and desquamation but not selective to the bladder tumour.

Adult↗
PubMed1983

False-positive liver scans due to portal hypertension: correlation with percutaneous transhepatic portograms in 33 patients.

Tc-99m-phytate scanning of the liver and percutaneous transhepatic catheterization of the portal vein were performed in 33 patients--26 with cirrhosis, 3 with chronic active hepatitis, 2 with idiopathic portal hypertension, and 2 with unresolved acute hepatitis. A discrete defect in the porta hepatis area was seen in 6 of 28 patients who had portal vein pressure above 200 mm H2O. In 5 of the 6 patients with a false-positive scan, the umbilical portion of the left portal vein branch was dilated (larger than 25 x 20 mm) on the portogram, with or without a patent paraumbilical vein. The anatomical basis of this phenomenon is discussed, and it is suggested that this area be given special attention.

Adult↗
PubMed1983

[CT diagnosis of hepatic and pancreatic cancers].

Accuracy of Diagnosis of 50 cases of operated hepatocellular carcinoma on CT is 96% Angio-CT which was performed under angiography could reveal small liver cancer with diameter of 3 approximately 5 mm and it is important for differential diagnosis between hepatocellular carcinoma and metastatic liver cancer to analyse inner sturcture of liver tumor. Accuracy of Diagnosis of 50 cases of pancreatic cancer on CT is 94%, and bolus injection method is very useful for diagnosis of small pancreatic cancer.

Carcinoma, Hepatocellular↗
PubMed1983

[Synchronous double cancer of the esophagus and the urinary bladder: report of two cases].

An 82-year-old man was seen with the complaints of gross hematuria and dysphagia in September 1979. An invasive bladder tumor was found and TUR-Bt (Transitional cell carcinoma, G2, pT3NXMO ) was performed. Fluoroscopic examination revealed a large esophageal cancer (Undifferentiated squamous cell carcinoma, T2NXMO ) and irradiation was performed (Linac 4,600 rads). The patient's condition aggravated rapidly and he died in February 1980. A 76-year-old man irradiated for an esophageal cancer (Linac 6,540 rads) (undifferentiated squamous cell carcinoma, T1NXMO ) in March 1981. Eleven months later, bladder cancer was found and treated with TUR-Bt (Transitional cell carcinoma, G2, PTlmNXMO ) followed by intravesical instillation of carboquone and adriamycin. The patient was alive 1 year and 9 months after the diagnosis of the esophageal cancer. Sixteen cases of double cancer of the esophagus and urinary bladder were found in the Japanese literature. Eighteen cases including the above 2 cases were males and their ages ranged from 51 to 82 years. Sixteen bladder cancers were transitional cell carcinoma and 15 esophagus cancers were squamous cell carcinoma. Of 9 cases whose clinical course were described in detail, 3 were synchronous and 6 were metachronous. Radical surgery was performed for one or both of the two cancers in 5 cases, 4 of which were metachronous. Indication of surgery for the metachronous second cancer does not differ significantly from sporadic cancer when the first cancer has been managed successfully. However, the treatment for the synchronous double cancer of this type of combination is often forced to be restricted, since the prognosis of esophageal cancer is poor and surgical risk may be increased by two radical surgeries in such elderly patients.

Aged↗
PubMed1982

Adult onset centronuclear myopathy with peripheral nerve involvement.

A case of centronuclear myopathy is presented, showing a rapid course in a 47-year-old male. Clinical and muscular findings were consistent with the diagnosis of centronuclear myopathy. On nerve biopsy, there was evidence of a regenerative process. Electron microscopy showed proliferation of Schwann cells with numerous Büngner's bands and other anomalies. This rare case with peripheral nerve changes may provide evidence to support the hypothesis of peripheral nerve involvement in centronuclear myopathy.

Cell Nucleus↗