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Biomedical subjects

N Cajal

Publications and source records attributed to N Cajal.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Investigations in the transforming activity of temperature-sensitive mutants of herpes simplex virus.

Transformation of rat embryo fibroblast was induced by a temperature-sensitive mutant of herpes simplex virus type 2. Transformation was scored using the morphological criterion of focus formation and the cell changes that lead to the final focus are described. Virus genome persistence in the transformed cell line was demonstrated by the presence of virus-specific membrane antigens and by the specificity of antibodies elicited in rabbits by inoculation of transformed cells. The cytogenetic analysis of the transformed cells revealed changes in chromosome number and the presence of marker chromosomes.

Animals↗
PubMedDate not supplied

The genetics of viral infection pathology.

The genetic diversity of viruses and the genetic constitution (polygenic configuration) of susceptible organisms participate together in the determination of a virus disease and of its clinical forms. Genes of sensitivity to viral infection, genes of nonspecific defense (encoding for interferons, complement factors), immune response regulating genes and immunoglobulin genes would form the background of an intrinsic polygenic group involved in viral infection pathology.

Alleles↗
PubMedDate not supplied

Serological investigations into the presence of antibodies to Yaba 1--Lednice 110 virus in Romania.

Sera collected from several migratory birds of the Danube Delta, from humans and domestic birds and animals of three Romanian counties were tested by hemagglutination-inhibition reaction for the presence of antibodies to Yaba 1--Lednice 110 virus. Antibodies could be detected in only 8 of the 14 species of migratory birds included in the study, especially in wild geese and ducks.

Animals↗
PubMedDate not supplied

Polycation-induced alterations of the envelope surface of influenza and parainfluenza viruses.

Natural macromolecular polycations (protamine, histones H1, H2A, H2B and H3) caused the clustering of influenza and parainfluenza viruses into aggregates heterogeneous in size, as well as a decrease in their hemagglutinating capacity. Polycation-induced virus alterations consisted in surface pyknosis and an increase most efficient as regards the interaction with viruses.

Chemical Phenomena↗
PubMedDate not supplied

Comparative study of some characteristics of influenza virus A/PR8/34 (H1N1) cultivated on chorioallantoic membrane fragments in the presence of ceruloplasmin or of parainfluenza type I (Sendai) virus.

Multiplication of influenza virus A/PR8/34 (H1N1) in the presence of either ceruloplasmin or parainfluenza type I (Sendai) virus results in the appearance of progens different from the parental virus as regards some of their biological properties. The role of viral envelope changes in acquiring new characteristics is discussed.

Allantois↗
PubMedDate not supplied

Trends in the rapid diagnosis of viral infections.

The authors discuss different aspects of the rapid diagnosis of viral infections: its necessity, its characteristics, the recent advances having allowed the development of modern techniques. Further, the main categories of procedures used in rapid viral diagnosis are reviewed: 1) electron microscopy, 2) immunofluorescence and immunoperoxidase techniques; 3) solid-phase systems with labelled reactants; 4) agglutination with supporting particles; 5) counterimmunoelectrophoresis; 6) rapid/early serological diagnosis. Data are discussed as regards the possibility of the large-scale application of rapid viral diagnosis procedures in Romania.

Agglutination Tests↗
PubMedDate not supplied

Transformation of human diploid cells by adenovirus type 4 irradiated with ultraviolet light.

Inoculation of ultraviolet (UV)-irradiated adenovirus type 4 (Ad4) led to in vitro transformation of human diploid cells (HDC). Two transformed cell lines could be established: cell line H 1418, from HDC inoculated with the 10(-3) dilution of Ad4 UV-irradiated for 20 min at a distance of 20 cm, co-cultivated with uninfected HDC, and cell line H 1557, from HDC inoculated with the 10(-2) dilution of Ad4 irradiated at the same distance for 12 min. Both transformed cell lines were resistant to superinfection with homologous virus. Virus-specific antigen could be made evident by the indirect immunofluorescence technique in the nuclei of both H 1418 and H 1557 cells.

Adenoviruses, Human↗
PubMedDate not supplied

Results obtained with the NIVGRIP inactivated influenza vaccine applicable by nasal and/or oral route.

The NIVGRIP inactivated influenza vaccine prepared in the "Stefan S. Nicolau" Institute of Virology has proved its efficacy in the specific prophylaxis of influenza. The vaccine can be administered by nasal and/or oral route and has a very low reactogenicity. Application of the NIVGRIP vaccine results in seroconversion rates of 50-70% and in rises in the levels of local neutralizing antibodies in 75-80% of the vaccines. Numerous epidemiological surveys have ascertained that the protection rate obtained by nasal administration of the NIVGRIP vaccine ranges from 50 to 90%, being comparable with that of other commercially available vaccines. The advantages of the use of an inactivated, whole virus vaccine applicable by nonparenteral routes are discussed.

Administration, Intranasal↗
PubMedDate not supplied

Evaluation of the prematurity risk on the ground of severity scores reflecting the action of different factors, maternal virus infection included.

A mathematical methodology is suggested which allows the a priori calculation of the risk of premature delivery, by a formula relying on the scores attributed to different specific risk factors (maternal virus infections included). The scores are estimated either directly, or starting from the scores of nonspecific factors. The statistical significance of the different scores, correlations and formulas is analyzed.

Adult↗
PubMedDate not supplied

Epidemiological evaluation of the protection conferred by the Nivgrip vaccine against influenza caused by the A(H3N2) virus.

The protection conferred by the inactivated influenza vaccine Nivgrip against influenza caused by the A(H3N2) virus was demonstrated in three school communities of a large urban centre during the epidemic outbreaks occurring in the winter season of 1983. The specific protection was reflected by the lower morbidity by influenza-like respiratory infections and by the absence or scarcity of postinfluenza complications in vaccinees.

Adolescent↗
PubMedDate not supplied

Persistent measles virus infection in a calf kidney cell line. Note II. Study of some biological markers of the measles virus isolated from a selected chronically infected cell line.

The biological characteristics of a measles virus strain (Co-69/pi) isolated from a selected chronically infected calf kidney cell line (K-2) are studied in comparison with those of thw wild parental CO-69 and of the attenuated Schwarz measles virus strain. Co-69/pi is a variant of the parental Co-69 virus and has characteristics of an attenuated strain. Some of the characteristics acquired by the Co-69/pi strain (cytopathogenicity, size of plaques) proved to be stable in the course of passages on a simian substrate. The mechanism having led to the appearance of this variant in the chronically infected cell line are discussed.

Cell Line↗