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Biomedical subjects

N Cajal

Publications and source records attributed to N Cajal.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Statistical studies on the epidemiology of human congenital malformations. Implications of maternal virus infections.

Prospective and retrospective statistical studies were performed in 1,000 cases of congenital malformations. The incidences and severity of the different types of malformations were correlated with the risk and protection factors having acted on the pregnant woman. The correlation coefficients were higher in the case of specific risk factors, among which special attention was paid to maternal virus infections. The possibility is discussed of developing a programme for the individual protection of high-risk cases, implying the compensation of the exposure to risk factors by the application of adequate protection factors, according to the calculated scores.

Congenital Abnormalities↗
PubMedDate not supplied

The effect of ceruloplasmin on the multiplication and on some biological and physico-chemical characteristics of influenza virus A/PR8/34 (H0N1) cultivated on chorioallantoic membrane fragments. Note 1. Kinetics of virus multiplication and of some biological characteristics in the presence and absence of ceruloplasmin.

The presence of ceruloplasmin in the inoculum inhibits the multiplication of influenza virus A/PR8/34 (H0N1) in chorioallantoic membrane fragments. Virus corpuscles that remain uncoupled to ceruloplasmin infect the host cells and their replication results in progens whose properties differ from those of controls inoculated in the absence of ceruloplasmin. The variation in time of the characteristics of the respective virus progens is discussed.

Allantois↗
PubMedDate not supplied

The effect of ceruloplasmin on the multiplication and on some biological and physico-chemical characteristics of influenza virus A/PR8/34 (H0N1) cultivated in chorioallantoic membrane fragments. Note 2. Modifications occurring in the course of serial passages.

The results obtained at the first passage of ceruloplasmin-incubated influenza virus A/PR8/34 (H0N1) in chorioallantoic membrane fragments demonstrate the "trap effect" of ceruloplasmin and are characterized by the low values of the ratios between the hemagglutinating and neuraminidase activities and the infectivity of the resulted progens. At the 2nd passage, both in the absence and in the presence of ceruloplasmin the previously observed changes are accompanied by severe modifications in the antigenicity of the progens, as shown by the HAI titres obtained against a rabbit antiserum to influenza virus A/PR8/34 (H0N1).

Allantois↗
PubMedDate not supplied

Presence of anti-albumin antibodies in viral hepatitis, infectious mononucleosis and several forms of cancer.

Anti-albumin antibodies previously described by different authors in viral hepatitis were also investigated in patients with other diseases. Significant titers of such antibodies could be detected -- by passive hemagglutination reactions using a system of bovine serum albumin-coated sheep red blood cells and human sera -- not only in viral hepatitis, but also in infectious mononucleosis cases and in patients with different forms of cancer. Onto-phylogenetic considerations on the significance of these antibodies for different stages of the process of cell de-differentiation or for disorders of intercellular contacts under the action of some viral agents are discussed.

Antibodies↗
PubMedDate not supplied

Investigations concerning the action of serveral chemical and biological agents on HBsAg.

Native and purified HBsAg preparations were subjected in vitro to the action of cetylpyridinium bromide (Bromocet), hibitan-chlorhexidine (Hibiscrub), chloramine B and propolis extract, at different concentrations and for various time intervals. The effect of these agents on the serological reactivity of HBsAg was tested by electroimmunodiffusion (EID) and radioimmunoassay (RIA). Chloramine B and the propolis extract had a significant inhibitory effect-ascertained by both EID and RIA - on purified HBsAg, but not on the native preparation. The inhibition exerted by Bromocet and Hibiscrub indicated by EID results was not confirmed by RIA.

Cetylpyridinium↗
PubMedDate not supplied

Persistent measles virus infection in a calf kidney cell line. Note IV. Electron microscopic observations in the K-2 cell line.

An electron microscopic study was performed in the K-2 calf kidney cell line persistently infected with measles virus. Aggregates of granular filamentous structures 20-30 nm in diameter were detected in the paranuclear zone of the cytoplasm. Rare, isolated smooth filaments 15-17 nm in diameter were also observed. No such structures were seen in the nucleus. The budding process was very active. Many pleomorphic particles ranging in diameter from 100 to 600 nm were observed at the cell surface and in the intercellular space; the particles contained a variable amount of filamentous nucleocapsid structures and had an envelope with discontinuous fuzzy material.

Animals↗
PubMedDate not supplied

The effect of ceruloplasmin on experimental infection with influenza virus APR 8/34 (H0N1) in the mouse.

Ceruloplasmin administered in different variants confers on mice protection against experimental infection with influenza virus APR 8/34 (H0N1). The optimal variants are: inoculation of an extemporaneous virus-ceruloplasmin mixture, followed by two additional ceruloplasmin applications (which confers maximum protection against initial infection) and the administration of ceruloplasmin prior to virus inoculation (which assures the highest resistance to challenge infection).

Animals↗
PubMedDate not supplied

Accidental transfusion of blood containing HBsAg or anti-HBs.

The presence of HBsAg and anti-HBs was tested in 2,099 surgery patients and in the blood left in 3,157 flasks after transfusion. It was found that accidental transfusion of HBsAg-containing blood had occurred. The 30 patients in which seropositivity correlations between recipients and transfused blood could be established were followed up clinically and serologically at 3, 6 and 12 months after transfusion. Out of the 13 initially seropositive patients 5 showed clinical or subclinical symptoms of viral hepatitis (V.H.). Most of the recipients of HBsAg-containing blood developed a biological response consisting in the appearance of either V.H. or anti-HBs. An increased number of fatal cases was recorded among recipients of anti-HBs-containing blood within 1 to 16 days post transfusion.

Antibodies, Viral↗