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Biomedical subjects

N Cajal

Publications and source records attributed to N Cajal.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Presence of C-reactive protein in the development of acute mumps infection. Preliminary report].

Investigations conducted on subjects with epidemic parotitis serologically confirmed (hemagglutination inhibition) allowed the detection of amounts of C reactive protein (Crp) higher than the normal level in 34% of the serum samples collected during the first twelve days of illness. After that, the Crp gradually decreased. The results showed that Crp is present in more than 40% of the subjects with uncomplicated mumps and in 55 to 75% of the cases with such complications as meningitis or orchitis. In most of the subjects, the Crp was found only in the first sample, but not in the second. Nevertheless, high amounts were found later, simultaneously with anti-mumps antibodies.

C-Reactive Protein↗
PubMedDate not supplied

Data on the experimental transmission in the guinea pig of some human chronic degenerative diseases: Creutzfeldt-Jakob and Alzheimer's disease.

Guinea pigs were inoculated intracerebrally with cerebrospinal fluid (CSF) and/or brain tissue suspensions from 8 patients with Creutzfeldt-Jakob disease (CJD) and with CSF from 2 patients with Alzheimer's disease. After a very long incubation period (over 360-420 days) a serially transmissible experimental disease appeared in the guinea pigs inoculated with CSF from 5 of the CJD patients, with either CSF or brain suspension from one CJD patient and with brain suspensions from the remaining 2 CJD patients. The disease was characterized by tremor, ataxia, convulsions and morphopathological lesions, such as spongiform change, glial hyperplasia and vacuolation of the neurons. Inoculations of CSF from the two Alzheimer's disease cases gave negative results.

Alzheimer Disease↗
PubMedDate not supplied

Research on respiratory virus diseases performed in the "Stefan S. Nicolau" Institute of Virology.

The studies on respiratory virus diseases performed for 30 years in the "Stefan S. Nicolau" Institute of Virology approached various aspects of the ecology of inlfuenza and parainfluenza viruses, adenoviruses and other respiratory viruses, including numerous experimental, fundamental, clinical and morphopathological investigations. Special attention was paid to specific influenza prophylaxis and to the preparation of an inactivated influenza vaccine applicable by nasal and oral route.

Animals↗
PubMedDate not supplied

Effect of several unpurified milk preparations on experimental influenza infection in mice.

Investigations were performed as regards the effect of the in vitro contact of influenza virus A/PR/8/34 (H1N1) with different milk preparations: boiled milk, milk acidified with lactic acid, supernatant from boiled yoghourt. It was the latter preparation that had the highest efficacy as regards the reduction of hemagglutinating (HA) titer following direct in vitro contact and the course of experimental influenza infection in mice. In the case of animals inoculated with influenza virus exposed to yoghourt supernatant HA titers in the lung homogenates were lower, mortality rates were reduced and the mean survival time was longer than in controls infected with untreated virus. Considerations are made on the possible mechanisms of the antiinfluenza action of yoghourt supernatant.

Animals↗
PubMedDate not supplied

Investigations of the antiviral activity of some nitroso-urea derivatives. Inhibitory action of the IOB-252 nitroso-urea derivative on vaccinia virus incell cultures.

The nitroso-urea derivative IOB-252 was administrered in monkey kidney cell cultures in a concentration of 40 mug/ml 24 hours before inoculation of vaccinia virus and maintained afterwards in a concentration of 25 mug/ml. The drug inhibited vaccinia virus multiplication, hemagglutinin synthesis and late cytopathic effect, but did not prevent early cytopathic lesions. IOB-252 inhibited the synthesis of interferon initiated by a viral inductor and blocked the antiviral effect of an exogeneous interferon. The mechanism of action of the drug is discussed.

Animals↗
PubMedDate not supplied

SSPE: epidemiological and serological features in a series of cases recorded between 1975 and 1984.

A number of 632 new cases of subacute sclerosing panencephalitis (SSPE) could be detected during a 10-year survey. The continuous increase in the number of annual cases suggests a possible correlation with the changes induced in measles epidemiology by the initiation of compulsory vaccination. On the other hand, a comparison of epidemiological and serological characteristics revealed significant differences between the series of SSPE cases recorded in the period preceding and in that following measles vaccination.

Age Factors↗
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Persistent measles virus infection in a calf kidney cell line. Note I. Establishment of calf kidney cell lines chronically infected with measles virus and some of their biological characteristics.

Several types of persistent measles virus infection resulting in lytic infections could be established in a calf kidney cell line, according to the passage level of the substrate and to the virus strain inoculated. Persistent measles virus infection in calf kidney cells was characterized by the limited proportion of infected cells, the large amount of infectant virus, and the alteration of morphological and growth characteristics of the cells. The mechanism of this persistent infection is discussed.

Animals↗
PubMedDate not supplied

Antimeasles vaccination by natural routes--experimental background and practical consequences.

A limited number of passages (up to 10) in human diploid cells (HDC) does not lead to changes in the phenotypic markers indicating the degree of attenuation of the vaccine strains of measles virus (Schwarz, Leningrad-16, Edmonston-Zagreb). At the same time, the increase in virus titer and the acquiring of immunogenicity when administered by nonparenteral (conjunctival, nasal) routes represent the prerequisites of a convenient form of application of the measles vaccine prepared in HDC.

Administration, Intranasal↗
PubMedDate not supplied

Effect of interferon on virus-transformed and tumor cell lines.

The cell growth inhibitory action of rat interferon (IFN) was investigated in two systems: a cell line obtained by transformation of rat embryo fibroblasts under the action of a ts mutant of herpes simplex virus and a tumor cell line derived from tumors induced in rats by transformed cells. The growth inhibitory effect of IFN, evaluated by cell counting and colony formation in soft agar medium, was dependent on the exponential cell growth rate and on the concentration of IFN in the medium. Long-time subcultivation of the two cell lines in the presence of IFN did not result in the selection of a cell population resistant to the growth inhibitory effect of IFN, but led to a decrease in the oncogenic potency of the tumor cell line.

Animals↗
PubMedDate not supplied

Investigation of the effect of cellular and viral nucleic acids on certain virus infections. Note 2. Effect of nucleic acids on virus multiplication in cell cultures.

Treatment of cell cultures with different natural nucleic acids prior to inoculation of herpes simplex virus type 1 led in certain cases to an obvious reduction in infectant titer. The reduction was maximum at a dose of 50 micrograms nucleic acid/culture tube and it was not dependent on the nature of the nucleic acid preparation. The antiviral effect of nucleic acids was enhanced by complexation with intercalation agents such as ethidium bromide or violamycin BI. No detectable amounts of interferon could be made evident in cell cultures treated with chromosomal DNA under conditions leading to a reduction by 1.75 log in infectant titer.

Aminoglycosides↗