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Biomedical subjects

M Wender

Publications and source records attributed to M Wender.

At least 91 records · Page 5Linked to original sources
PubMed1984

Myelin associated glycoprotein (MAG) in Wallerian degeneration of the optic nerve.

The content of myelin associated glycoprotein (MAG) was studied in the rabbit optic nerves undergoing Wallerian degeneration after ophthalmectomy . MAG was estimated according to the method described by Matthieu and Quarles (1973). The results of the studies demonstrated only negligible changes in the content of MAG in the course of central Wallerian degeneration. These experiments do not support the assumption that the periaxionally localized MAG of the central myelin is as a rule seriously involved in subcellular mechanisms functioning in early stages of central demyelinating processes.

Animals↗
PubMed1984

[Primary tumors of the nervous system in the light of an epidemiologic analysis].

On a territory of 5 districts of western Poland with 3.097 thousands of inhabitants the annual incidence rates per 100 thousands of population as well as the prevalence rates of primary neoplasms have been determined. The results of our investigation have shown that multiforme glioblastomas and astrocytomas occurred in the investigated population with the highest annual incidence rates, whereas the highest prevalence rates were found for hypophyseal adenomas, to be followed by astrocytomas, meningiomas and glioblastoma multiforme. The obtained results are critically discussed and compared with epidemiological data presented by other authors who based on records from neurosurgical departments and autoptic sections, it is concluded that the presented results do reflect objectively the epidemiological situation of Poland.

Adenoma↗
PubMed1983

The pattern of myelin proteins in triethyltin (TET) intoxication.

Myelin proteins isolated from the brain of Wistar rats intoxicated chronically with triethyltin sulfate (TET) according to the technique of ETO et al. (1971) were investigated. Among the various protein fractions, the Agraval protein happened to be most evidently affected, demonstrating considerably reduced percentages. However the results did not prove that any of the individual myelin proteins was specifically affected by TET intake. The interesting point in chronic TET poisoning was that some clinical symptoms as well as disturbances in myelin proteins demonstrated a clear tendency to retrogression despite of the continued intoxication. These observations indicate obviously that during chronic TET intake, some kind of biochemical adaptation to the noxious action of the poison on the myelin sheath takes place.

Animals↗
PubMed1983

Myelin proteins in Wallerian degeneration of the optic nerve.

The development of changes in the protein spectrum of the rabbit optic nerve undergoing Wallerian degeneration was studied and compared with the time sequence of the previously established changes occurring in the lipid composition of the degenerating nerve. The myelin protein spectrum remained essentially unchanged till 32 days after enucleation to show a decrease of the relative content of basic myelin proteins accompanied by increased percentages of the Wolfgram protein during the forthcoming development of Wallerian degeneration. The occurrence of changes in the myelin protein spectrum was significantly delayed in comparison with the onset of enhanced esterification of myelin cholesterol, and thus the latter process, and not the hydrolysis of basic protein is considered as an early event, weakening the molecular structure of the myelin membrane that might initiate the demyelinating process.

Animals↗
PubMed1982

[Nervous system diseases in large-city population. II. Effect of occupational factors].

The patients of a local outpatient department in a half--million population town have been examined. The rate of organic angiogenic encephalopathies, vasomotor headaches and epilepsy has been three times greater in those performing light work than in the hard-working group. No dependency between the hard work and rate of ischias and lumbago has been found. Operations of productive machines, similarly as the working place microclimatic conditions do not pose a risk of nervous system diseases, except ischias and lumbago which occur more frequently in an occupational group working at low temperature and considerable humidity or at an open air. Likewise, the body position at work significantly affects the rate of ischias and lumbago. Our findings prove that hard work does not pose an additional risk of nervous system diseases. Another conclusion of those investigations is that advantageous microclimate and body position at the working place, possibly accompanied by corrective physical training, are significant in the prevention of ischias and lumbago.

Adolescent↗
PubMed1981

Wallerian degeneration of the optic nerve in light of histological and biochemical studies.

Wallerian degeneration of the rabbit optic nerve was produced by enucleation. The ultrastructure, enzyme histochemistry, myelin output as well as the lipid composition of degenerated nerve were studied. The obtained results lead to following conclusions: 1. Esterified cholesterol appeared in the lipid spectrum of myelin membranes undergoing Wallerian degeneration preceding a significant drop of myelin mass, without an involvement of lipomacrophages and without notable changes in the structure of myelin. 2. Esterification of cholesterol could function as a primary factor injuring the myelin membrane in central Wallerian degeneration, similarly as in other demyelinating processes. 3. Lipomacrophages occurring in the later stage of Wallerian degeneration of the optic nerve are of astroglial origin. 4. The slow progress of phagocytosis in the degenerating optic nerve might explain the almost unaffected pattern of myelin lipids in the course of Wallerian degeneration of this structure. 5. Lysocompounds play an important role in the pathomechanism of demyelination in the central nervous system including the optic nerve during further steps of myelin decay.

Animals↗
PubMed1981

Lipids of the oligodendroglial fraction in methylnitrosourea induced encephalopathy.

The investigations were performed on oligodendroglial cells isolated from the cerebral white matter of Wistar rats treated intravenously with a 3% solution of MNU at a dose of 60 mg/kg body weight. The oligodendroglial fraction showed a decrease of the sphingomyelin, phosphatidylserine and phosphoinositides content. The observed changes correlated with alterations of the lipid spectrum found in the myelin fraction of MNU intoxicated rats. This would indicate that MNU acting in the central nervous system affects in a similar way the lipid metabolism of both components of the oligodendroglia-myelin system.

Animals↗