Search PubMed⌕ Search

Biomedical subjects

M Wender

Publications and source records attributed to M Wender.

At least 55 records · Page 3Linked to original sources
PubMed1989

Influence of experimental hypoxia on content and composition of free fatty acids in cerebral white matter.

The content and spectrum of free fatty acids were studied in the cerebral white matter, on Wistar rats exposed to acute hypoxia (2% of oxygen in a respiratory mixture) for 3 min. The total content of fatty acids, especially of tetraenoic ones, rose sharply already 4 min after hypoxia and persisted elevated even 2 months after the hypoxia. The results showed that the degradation of phospholipids-containing biological membranes in the nervous tissue of the white matter starts immediately after hypoxia, and is continued for months.

Animals↗
PubMed1989

[Epidemiology of Parkinson disease in the Pozna'n province].

The authors analyzed the prevalence and incidence of parkinsonism in the Poznań region. The research led to the following conclusions: 1. Incidence of parkinsonism in the Poznań region amounts to 12.6 per 100,000 of population, which is the middle value of scatter in the investigation on a world-scale. The prevalence of the disease--65.9 per 100,000--is the lower range of values found in many countries of the world. This seems to point to a shorter survival time of patients with parkinsonism in our country. 2. Among various age groups, the highest incidence and prevalence of parkinsonism is found in the age groups of 70-79 and 80-89, with slightly higher prevalence rates among males. 3. The authors found in the Poznań region irregular prevalence of parkinsonism, that is the existence of small focuses of the disease, which seems to depend on unfavourable genetic factors existing in those places.

Adult↗
PubMed1988

Myelin lipids in aging human brain.

The studies were performed on autopsy material of 18 patients who died between the ages of 70-89 y, and of 5 patients who died between 23-44 ys of age. White matter of the frontal lobe and of oerebellum was submitted for histological and biochemical analysis. The neuropathological data provided a rationale for dividing the material into two subgroups: one including patients mainly with vascular changes in the brain, and the other consisting of patients with senile atrophy of the Alzheimer type. Chemical alterations noted both in frontal lobe and in cerebellum were an increase in lysophosphatidylcholine content and a marked decrease in myelin yield. Additionally, in cerebellum a decrease in sulphatide content was observed. The chemical results were almost identical in the two subgroups of patients, although they differ in neuropathological patterns of lesions. It is emphasized that the general decrease in myelin yield as well as some minor changes in myelin lipid pattern seem to be a sign of aging and are not connected with atrophy of the Alzheimer type.

Adult↗
PubMed1988

Myelin lipids of the rat brain in experimental hypoxia.

The pattern of cerebral myelin lipids was studied in Wistar rats exposed to mild hypoxia (7% of oxygen in a respiratory mixture) for 30 min. The most pronounced change involved a marked increase in cholesterol esters and lysophosphatidylcholine content in the myelin fraction. The results obtained indicate that mild hypoxia induces a lesion of myelin membranes but does not provoke the reaction of lymphocytes and macrophages, which by production of myelinolytic factors, evoke demyelination.

Animals↗
PubMed1988

Karyometric and cytophotometric studies of the oligodendroglia in the corpus callosum of the rat after hypoxia.

Karyometric and cytophotometric investigations were conducted using an automatic analyser "Morphoquant" on oligodendroglial nuclei of corpus callosum following acute or moderate hypoxia in Wistar rats. Results of our studies demonstrated karyometric changes in nuclei of oligodendroglia cells after hypoxia, with deviations distinct in the early and late period after exposure to hypoxia. Cytophotometric analysis of a relative DNA content in cell nuclei of oligodendroglia demonstrated an increased extinction of DNA in the early period and a decreased extinction in the late period after acute or moderate hypoxia. The changes in oligodendroglia may be primarily responsible for the molecular structure lesion in myelin, observed as a result of hypoxia.

Animals↗