Biomedical subjects
Publications and source records attributed to M Varga.
The results of parenteral treatment with Etaretin in 40 patients (79 eyes) suffering from senile maculopathy are reported. In 84% of the cases there was a degeneration of the dry type and in 16% a disciform exudative maculopathy. The cases of dry maculopathy responded well within a floow-up period of 8 to 18 months.
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A case of a recurrent epibulbar naevus is presented; it underwent malignant transformation and subsequently invaded the eyeball. The tumour histologically was a predominantly epitheloid cell melanoma containing numerous histiocytes and degenerated tumour cells. Electron microscopy revealed rare special structures, e.g. annulated lamellae, tubuloreticular structures, pseudocrystals in huge mitochondria. Besides, invasion of tumour cells into a capillary could be shown.
Increased alcohol tolerance following chronic alcohol administration has been explained by increased mitochondrial oxidation of NADH and or increased activation of MEOS. According to our experiments this increased tolerance after chronic alcohol consumption is connected with an increased activity of ADH.
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We report on a 14-year-old boy who, at the age of 6 months, developed groups of pin head-sized protuberances on a bay leaf-shaped area of the skin above and below the left clavicle. These skin eruptions become more prominent in response to heat and cold, but cause no complaints. The histological picture shows longitudinal and cross sections of mm. arrectorum pilorum in large numbers.
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A 14-years-old girl suddenly developed typical dermal signs of ashy-dermatosis at the time of menarche. After one year, the signs began to fade and had disappeared completely two years later. The direct immunofluorescence and the ultrastructure resemble lichen planus. Endocrine factors may have played a part in the presented case, considering the sudden onset at the time of menarche.
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Authors investigated the natural killer and antibody dependent cellular cytotoxicity functions of lymphocytes in cervical cancer patients. According to the results the natural killer function showed remarkable changes related to the extent and the course of the disease. On the contrary, radiation therapy did not influence this function. The antibody dependent cellular cytotoxicity function of the same lymphocytes did not show any alteration under circumstances mentioned above.
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Natural cell-mediated cytotoxicity (NCMC) against a cell line (K-562) and antibody-dependent cellular cytotoxicity (ADCC) against the same target and against chicken red blood cells were investigated in two age groups (20--45 and 70--98 years old). Proliferative response to PHA and to allogenic cells as well as some subpopulation determinations were also carried out only lymphocytes of the same subjects. In contrast to the significantly decreased proliferative responses, NCMC showed a moderate, and the two ADCC values a highly significant increase in the group of aged subjects. These increased values showed some similarities with the quantitative changes within the T-lymphocyte subpopulations. The incidence of serum samples of NCMC inhibitory activity was only moderately increased in the group of aged subjects as compared to that of the young individuals. On the basis of these results, we concluded that the immune system of healthy aged subjects seems altered or inbalanced rather than depressed to that of the young individuals.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.