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Biomedical subjects

M Varga

Publications and source records attributed to M Varga.

At least 73 records · Page 4Linked to original sources
PubMed1990

Effect of a novel soft steroid on the wound healing of rabbit cornea.

The effect of a 'soft' anti-inflammatory corticosteroid on the corneal wound healing was investigated in rabbits. Albino rabbits were treated with soft steroid and dexamethasone after linear perforating corneal incision. Soft drug design is aimed to control and direct the drug activity and in vivo metabolism to nontoxic moieties. These drugs are rapidly deactivated after they reach the general circulation. While having good local activity, they thus possess high therapeutic indexes without systemic side effects. The wound healing process was evaluated qualitatively by histology. Photomicrographs are presented to show that the soft steroid is as or more effective than dexamethasone in minimizing scarring in addition to its advantageous metabolic properties. This soft steroid may be an efficient anti-inflammatory and anti-allergic agent in topical application without the majority of unwanted activities of traditional drugs by deliberately simplifying their disposition.

Androstadienes↗
PubMed1990

[Direct measurement of the pulling force affecting the flexor tendons of the hand].

A thought, returning again and again in hand surgery, is the immediate introduction of active motion therapy after the reconstructive operations of the flexor tendons. To the active motion an adequately strong tendon suture, to the definition of "adequately strong tendon suture" however the measurement of the pulling force, acting actually on the flexor tendons is necessary. Authors attempted to measure this pulling force during flexor tendon operations on cadaver's hand. On the basis of their measurements the maximal pulling force, that can be expected during postoperative active movement exercises with adequate circumspection, can be estimated as two kiloponds.

Exercise Therapy↗
PubMed1990

[Discoid lupus erythematosus beginning on the eyelids].

We report on a 20-year-old women, who suffered from discoid lupus erythematosus (DLE) beginning on her eyelids with dyschromia and cutaneous infiltration. Similar signs appeared on the top of her nose, her nostrils, and her lower lip. Simultaneously with these alterations, we found a superficial exulceration on her hard palate, which histologically proved typical for DLE. After therapy with chloroquine for 3 weeks, the alterations disappeared.

Adolescent↗
PubMed1990

[Measurement of the tensile force exerted on the flexor tendons of the hand].

Immediate postoperative active motion after flexor tendon repair is a recurring theme in hand surgery. In the present study the authors determined the tensile stress of the sutured tendon subjected to active motion by the use of cadaveric hands and a tensiometer. The force necessary to draw forth the proximal stump was also measured. A tendon suture which can resist two kilo-ponds tensile force seems to allow active motion of the reconstructed flexor tendon.

Exercise Therapy↗
PubMed1990

[Variabilities of kinetics of alcohol catabolism].

The resorption, distribution and elimination of ethanol vary individually. The differences in the resorption deficit and elimination coefficient can be of great extent. Though the generally accepted average of resorption deficit is 20%, which is calculated with in forensic practice, this value can occasionally be a lot higher. The elimination coefficient (beta value) depends on the blood alcohol level. Beta value was found higher than 0.15%o/h, the generally accepted one, even below 1.5% blood alcohol content, above 2.5% the beta value was found to be as high as 0.33%o h. This faster rate of ethanol clearance is due to induction of alcohol elimination systems. The ethanol metabolism at higher blood alcohol levels is characterized by Michaelis-Menten kinetics.

Alcohol Drinking↗
PubMed1989

A case of Churg-Strauss syndrome.

A 54-year-old woman died after being battered, but the forensic autopsy revealed that her injuries were not serious or lethal. A detailed histological examination revealed that the basic disease had been Churg-Strauss syndrome. The differentiation of this syndrome of pulmonary infiltration and eosinophilia (PIE syndrome) from other allergic and noninfectious granulomatoses needs cautions consideration.

Churg-Strauss Syndrome↗
PubMed1989

The effect of timolol, betaxolol and levobunolol on the surface of rabbit cornea.

Pigmented rabbits were treated with timolol maleate, betaxolol hydrochloride or levobunolol hydrochloride eye drops twice a day for six months. Animals of the same age group and breed were used as controls. There were no differences observed in corneal epithelium with light and transmission electron microscopy. With scanning electron microscopy, in the timolol and betaxolol treated animals the picture of the corneal surface was similar to that of normal rabbit corneas after exposure to air. In scanning electron micrographs of the levobunolol treated animals, the corneal surface resembled the corneas of normal rabbits treated with artificial tears.

Administration, Topical↗
PubMed1989

Some morphometric evidence of hepatoprotective effects of (+)-cyanidanol-3.

The (+)-cyanidanol-3 is used as an antihepatotoxic and hepatoprotective drug in both men and animals against alcoholic and experimental liver injury. Histologic staining techniques give mostly qualitative or semiquantitative description of liver damages. Experiments have been carried out to determine the hepatoprotective effects of (+)-cyanidanol-3 on alcoholic liver damage (i.e., fatty liver and hepatomegaly) by morphometric measurement of the liver tissue sections. Ethanol was administered ad lib to CFY rats to cause mild alcoholic liver damage together with 200 mg/kg/day (+)-cyanidanol-3 to prevent the tissue deterioration. The changes of hepatic lobule and hepatocytes were measured morphometrically. The chronic ethanol consumption results in hepatocellular hypertrophy, a significant increase in size of the hepatocytes and a mild increase of the intralobular extrahepatocytic space as well when compared with controls. The volume of cytoplasm was increased while the parameters of nuclei were unchanged. The (+)-cyanidanol-3 prevents changes and the morphometric parameters in the treated group were almost the same as in the controls. The treatment with (+)-cyanidanol-3 alone does not affect the hepatic tissue parameters. The results show the hepatoprotective effect of (+)-cyanidanol-3 and the suitability of the morphometric method for quantitative comparison of normal and experimentally-altered liver cells.

Animals↗
PubMed1989

Drug identification problems in two suicides with neuromuscular blocking agents.

Cases of suicide committed with neuromuscular blocking agents have been investigated. Both cases involved anesthesiologists who took the muscle relaxants suxamethonium chloride (Sukolin) or pipecuronium bromide (Arduan) and a rapid-acting barbiturate, 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin). The examinations were performed by using gas chromatography and mass spectrometry. The quantitative data obtained showed that doses useful in general anesthesiological practice were applied. Metabolites were found despite their fast metabolizing character.

Adult↗
PubMed1988

A suicide with neuromuscular blocker.

We experienced an autopsy case in which a 29-year-old woman committed suicide by parenteral application of a neuromuscular blocker combined with thiobarbital. These medicines were easily accessible to the victim who was an anesthesiologist in a hospital. Paralyzing the respiratory muscles the usual dose of neuromuscular blockers can cause death unless a breathing apparatus is used. Unusual medicines given in small doses are difficult to detect in the autopsy materials. In our case in the course of forensic investigation we successfully identified the traces of a neuromuscular blocker by mass spectrometry.

Adult↗
PubMed1988

A simple method for postmortem detection of acute myocardial infarction.

The analysis of K/Na ion ratio of myocardium was used for the postmortal determination of the early myocardial infarction. The ion content of heart tissue was measured with flame spectrometer after the decomposition of myocardium by Lumatom tissue solubizer. The ion contents and their ratios correlate well with the electrocardiogram, the clinical data, the autopsy and histological findings. In some cases the change of the K/Na ion ratio was the only alteration that suggested an early stage of myocardial infarction. The Lumatom tissue solubizer can be very useful in determination of trace elements from any organic samples.

Autopsy↗
PubMed1987

Sudden death caused by hydatid embolism.

An 18-year-old man died on the spot during a foot race. Previously, he had been in a healthy condition. Since the cause of his sudden death was unknown, a forensic autopsy was carried out. The autopsy revealed hydatid cysts in the right ventricle of the heart some of which had embolized the pulmonary arteries. In case of sudden death in endemic areas the possibility of a hydatid disease should be taken into consideration.

Adolescent↗
PubMed1986

A caliber-persistent artery of the gastric wall resulting in fatal haemorrhage.

A 12-year-old girl was admitted to hospital with haematemesis. Her family suffered from histidinaemia. Due to her numerous injuries the police suspected a crime. After a short period of clinical treatment she died. Autopsy showed the left ureter to be narrowed and a consecutive abscedens pyelonephritis. Pyloric ulcer caused erosion of a caliber-persistent artery which led to death with haemorrhage. The death had nothing to do with violence. Adequate surgical treatment could have saved the patient's life.

Arteries↗
PubMed1986

Vena occlusive disease simulated by a metastasis of gastric cancer during pregnancy.

A 20-year-old woman was treated because of her complaint and symptoms which were thought to be the results or complication of her pregnancy. Based on the cardinal symptom inferior cavography was carried out, and the diagnosis of occlusion of inferior vena cava was established. The woman was treated accordingly but died after a short period. The patient's family supposed neglection and therapeutic misadventure and raised an objection to the medical treatment. Forensic autopsy was carried out to clear up the case. Autopsy showed her basic disease to be gastric cancer with several metastases in the liver. One of them was in the lobus caudatus Spigeli and compressed the inferior vena cava. The compression caused a turbulence in the given contrast material so that thrombosis was suggested. The diagnosis was based on this misleading sign. Negligence was not verified.

Adenocarcinoma, Mucinous↗