Search PubMed⌕ Search

Biomedical subjects

M Varga

Publications and source records attributed to M Varga.

At least 109 records · Page 6Linked to original sources
PubMed1980

Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor.

Natural killer (NK) cell activity, antibody-dependent cytotoxicity (ADCC) and the effect of interferon on NK activity was investigated in multiple sclerosis (MS) patients. NK activity measured against K-562 tumour cell line was found to be significantly low in MS patients, and this was most pronounced in the group of male patients with definitive disease. The response of NK cells to interferon proved to be impaired and almost no activation could be demonstrated in response to polyinosinic-polycytidylic acid (poly I:C). Preliminary data obtained by the determination of interferon production in several definitive MS cases reflect a defect in the interferon producing capacity of lymphocytes. The possible involvement of impaired NK cell function in the aetiopathogenesis of MS is discussed.

Adult↗
PubMed1979

Experiences with the Fox technique for the repair of senile entropion.

The author reports on the advantages of Fox's technique in the surgery of senile entropion on the basis of experiences with 30 interventions on 26 patients. In the evolution of senile entropion the structural changes in the orbicularis oculi muscle plays a decisive role, which leads to the malfunction of the muscle. The degenerative changes of the muscle are shown with electron microscopy. The author recommends the Fox technique because this type of intervention aims to abolish the cause of the aging process and not only the consequences of it as other methods do.

Aged↗
PubMed1979

Correlation between effector lymphocytes in natural and antibody-mediated cytotoxicity.

Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxic activity could always be found in serum-free medium. While these findings suggest the involvement of antibodies in the SCMC, they also reflect the existence of serum-indpendent (sui generis) SCMC activity of lymphocytes. Removal of SCMC of Fc receptor bearing effector cells was performed by target cell adherence (rosetting). Separation of the target cell-bound lymphocytes was done by centrifugation on special Ficoll gradient. The depletion of SCMC effector cells resulted in a 62% reduction of SCMC and in a 39% reduction of ADCC. On the other hand, removal of Fc bearing effector cells showed a similar reduction in both ADCC (66%) and SCMC (78%). Our results suggest that SCMC represents a complex activity, arising partly from the interactions of certain serum-derived or lymphocytes surface-bound antibodies and partly from a spontaneous cytotoxic function of the effector cells. It is possible that the effector cells involved in both SCMC and ADCC derive from the same lymphocyte population and the differences are due mainly to the lower number of SCMC effector cells.

Animals↗
PubMed1979

The natural killer activity (cytotoxicity) of lymphocytes.

The authors' own investigations into the spontaneous lymphocyte-mediated cytotoxicity (SLMC) have been reviewed and discussed in th light of literary data. It is suggested that SLMC is a resultant of complex effects contributed by antibodies present in the human serum and those attached to the surface of lymphocytes as well as by spontaneous (sui generis) functions of effector cells. The lymphocytes eliciting SLMC belong to the "O" subpopulation, bear Fc receptors and are presumably, identical with "K" lymphocytes. In animal experiments, the authors have shown that the SLMC reaction directed againt a virus-induced tumour is under polygenetic control primarily governed by gene(s0 linked to the histocompatibility region. In man, similarly as in the mouse, SLMC was found to be a genetically-controlled lymphocyte function in which gene(s) linked to the HLA-A2 B12 or the HLA-A3 B7 haplotype may play a determining role. The authors' clinical observations indicate that LSMC represents an important part of the defense mechanism against malignancies and autoimmune diseases. Estimation and follow-up of SLMC may be useful in monitoring the clinical course.

Animals↗
PubMed1977

Antibody dependent and spontaneous lymphocyte mediated cytotoxicity in normal subjects, patients with SLE, and malignancies.

Antibody dependent and spontaneous lymphocyte mediated cytotoxicity was studied in healthy subjects and patients with systemic lupus erythematosus and metastatic tumours. The purified peripheral blood lymphocytes of healthy subjects exerted a similar cytotoxic activity on allogeneic K-562 and xenogeneic chicken erythrocyte targets in the antibody dependent and spontaneous lymphocyte mediated cytotoxicity tests. There was a stronger correlation between the cytotoxicity measured in the two allogeneic assays than between allogeneic and xenogeneic tests. Allogeneic systems using K-562 targets were more sensitive to changes in cytotoxic activity in systemic lupus erythematosus and metastatic tumours than was the xenogeneic chicken erythrocyte assay.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1976

Recent experiences on the ophthalmologic complications of oral contraceptives.

I have added 16 cases to the preciously reported 4 cases where ophthalmologic complications occurred in connection with oral contraceptives. In some cases, occlusion of the central retinal artery, prethrombosis of the central retinal vein, prolonged narrowing of the retinal arteries, perivasculitis, hemorrhage in the macular region, and inflammations of the anterior segment of the eye, resistance to therapy developed, and in some cases, lesions of the optic nerve causing visual loss of different degree and papillitis occurred. In the background of the different clinical entities, common pathologic origin might be supposed,--the disturbance of the chorooretinal circulation. In patients taking the pill for the longest time interval, delicate lenticular opacities developed.

Adult↗
PubMed1975

Metastatic tumor of the orbit.

Metastatic tumor occurred in the right orbit of a 50-year-old woman 5 years following bilateral mastectomy. The tumor caused enophthalmus, ptosis and restriction of the ocular movements. The tumor consisted of nondifferentiated cells. Transmission and scanning electron microscopic appearance of the tumor is also reported.

Breast Neoplasms↗