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Biomedical subjects

M S Hutt

Publications and source records attributed to M S Hutt.

At least 55 records · Page 3Linked to original sources
PubMed1979

Solar keratosis, pterygium, and squamous cell carcinoma of the conjunctiva in Malawi.

The histological features of 234 conjunctival biopsies from Africans in Malawi have been re-examined. The appearances of solar keratosis, pinguecula, and pterygium are presented as part of a continuous spectrum of the same pathological process and aetiology, which may lead to carcinomatous change. The results are discussed with regard to the specific geographical distribution of such lesions found by other workers, with particular emphasis on ultraviolet radiation as the main aetiological factor.

Carcinoma, Squamous Cell↗
PubMed1979

Epstein-Barr virus antibodies in Sudanese patients with nasopharyngeal carcinoma: a preliminary report.

With the use of an immunofluorescence technique Epstein-Barr viral capsid antigen antibody titers were determined in the sera from 226 Sudanese: 41 with nasopharyngeal carcinoma (NPC), 77 with other head and neck cancers, 21 with malignant lymphomas, 63 with other cancers, 6 with specific granulomas, and 18 normal controls. Of the NPC patients, 87.8% had titers of 320 or greater and 43.9% had titers of 2,560 or more, whereas none had titers of less than 40. Their geometric mean titer (GMT) level was 1,855. However, compared to the NPC patients, the other patients and normal controls showed significantly higher percentages of sera with low titers and lower percentages of sera with high titers and they had a GMT that was 4--16 times lower. The high NPC titers were independent of age, sex, tribe, or locality of patients. The preliminary results indicated the importance of future immunovirologic and immunogenetic field investigations on the natural history of the Epstein-Barr virus and on the genetics of the host.

Adolescent↗
PubMed1979

Epidemiology of chronic intestinal disease in middle Africa.

Gastrointestinal disease in middle Africa is changing. The traditional patterns were high frequencies of parasitic and infectious diseases and sigmoid volvulus, and low incidences of colonic polyps, carcinoma of the colon, appendicitis, diverticulosis, ulcerative colitis and Crohn's disease. The current disease patterns are compared with those for gastrointestinal disease in developed countries and etiological factors are discussed.

Africa, Central↗
PubMed1978

Chronic malarial infection of mice: A comparison of single and multiple infections with Plasmodium berghei following P. yoelii.

Chronic malarial infection was induced in two groups of BALB/c mice by injection of Plasmodium yoelii followed by either one or repeated injections of P. berghei. Both groups showed a continuing but fluctuating splenomegaly, and a considerably increased reticulocyte count which also varied regularly, over a period of six months. During this time many mice had a very low grade parasitaemia demonstrable by subinoculation of blood into uninfected recipients. Mice infected with P. yoelii alone did not show any of these changes. One year after the first malarial attack all the infected mice had higher fluorescent antibody titres to P. yoelii than to P. berghei, titres against which were very low. Infected mice showed an increase in plasma cell proliferation in the red pulp of the spleen. There was a significant difference between mice which had received multiple injections of P. berghei and the other infected animals; the former had many germinal centres in the spleen, while the other infected groups did not.

Animals↗
PubMed1975

Chronic malarial infection in Balb/C mice. Effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen.

Chronic malarial infection was established in Balb/c mice by following Plasmodium berghei yoelii with P.b. berghei infection. It was found that the IgG plaque-forming cell response to sheep erythrocytes was depressed for at least six months. A preliminary investigation of the histological changes in the spleen and liver is described. The possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed.

Animals↗
PubMed1975

Malarial infections in Aotus trivirgatus with special reference to renal pathology. II. P. falciparum and mixed malaria infections.

This paper describe the renal pathology in Aotus trivirgatus (owl monkeys) following P. falciparum infections and also when the initial P. falciparum was followed by infection with P. malariae or P. brrasilianum. Acute P. falciparum infections were associted with high parasitaemia but relatively mild changes in the glomeruli. This was also the case when a second infection with P. falciparum was given after the first infection had been terminated with chloroquine. Four monkeys with multiple infections involving P. Malariae or P. brasilianum after P. falciparum showed a glomerulonephritis. Two of these also showed a necrotizing arteriolitis. The findings suggest that P. falciparum alone does not give progressive renal disease and that this is more likely to occur with mixed infections.

Animals↗