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Biomedical subjects

M S Hutt

Publications and source records attributed to M S Hutt.

At least 73 records · Page 4Linked to original sources

Nephrotic syndrome in monkey infected with human quartan malaria.

A splenectomized aotus monkey infected with human quartan malaria (Plasmodium malariae) developed oedema and proteinuria. Histological examination revealed a generalized diffuse glomerulonephritis and immunofluorescent staining showed granular deposits of IgM in the glomeruli. The pathological picture resembled that shown by human patients with the quartan malaria nephrotic syndrome.

Animals↗

Clinical trial of malaria prophylaxis in tropical splenomegaly syndrome.

A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.

Adolescent↗