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Biomedical subjects

M Rose

Publications and source records attributed to M Rose.

At least 199 records · Page 11Linked to original sources
PubMed1988

Recombination within the class III region by a double cross over event.

Analysis of class I, class II, and class III gene products of the human MHC in a Caucasoid family with four children gave evidence for a double crossing over event in monozygotic twins between the C2, Bf/C4A, C4B gene loci. In view of the small genetic distance between C2 and C4, a point mutation within the Bf locus must be considered alternatively.

Crossing Over, Genetic↗
PubMed1988

Localisation of atrial natriuretic peptide immunoreactivity in the ventricular myocardium and conduction system of the human fetal and adult heart.

Atrial natriuretic peptide immunoreactivity was found in ventricular and atrial tissues with specific antisera raised to the amino and carboxy terminal regions of the precursor molecule. In 13 developing human hearts (7-24 weeks' gestation) the immunoreactivity was concentrated in the atrial myocardium and ventricular conduction system but it was also detected in the early fetal ventricular myocardium. Immunoreactivity in five normal adults was largely confined to the atrial myocardium although it was also found in the ventricular conduction tissues of hearts removed from 10 patients who were undergoing cardiac transplantation. The ventricular conduction system is an extra-atrial site for the synthesis of atrial natriuretic peptide. In the failing heart this synthesis may be further supplemented by expression of the gene in the ventricular myocardium. It is possible that ventricular production of the peptide contributes to the raised circulating concentrations of atrial natriuretic peptide immunoreactivity found in severe congestive heart disease, particularly in patients with dilated cardiomyopathy.

Adolescent↗
PubMed1987

Model of TPN-associated hepatobiliary dysfunction in the young pig.

Gallbladder 'sludge' and cholestasis are two common complications associated with total parenteral nutrition (TPN), but the aetiology of each is uncertain. An animal model has been developed in the young pig which demonstrates these two complications. Five female piglets, of Landrace Large White Cross variety weighing 4.5-5.9 kg, received nutritional support for 2 weeks with a continuous infusion of TPN solution at a dose of 150 kcal kg-1 day-1. The solution was 35 per cent dextrose, 5 per cent L-amino acids with conventional electrolyte, mineral and vitamin additives. No lipid was used in the solution. Five weight-matched animals were used as controls. All animals in the TPN group developed 'sludge' in their gallbladders, decreased basal bile flow, decreased bile salt excretion and a diminished response to bile salt stimulated bile flow, as compared with controls. There was no abnormality in routine liver function tests or liver histology. It is concluded that TPN therapy in this animal model is associated with the appearance of gallbladder 'sludge', and cholestasis as demonstrated by direct bile flow studies. It is suggested that this bile flow abnormality is due to a decrease in bile salt dependent and bile salt independent fractions of canalicular bile flow. The model provides the opportunity to investigate TPN related hepatobiliary dysfunction in an animal that has similar liver function to man and comparable nutritional requirements.

Animals↗
PubMed1987

High incidence of relapses in thrombotic thrombocytopenic purpura. Clinical study of 38 patients.

Described in this study are 38 patients who received treatment for thrombotic thrombocytopenic purpura in 15 hospitals in Israel and the New York City area since 1977, when plasma therapy was introduced. Thirty-seven patients received plasma therapy and 30 survived. In 12 patients (37 percent of survivors), relapsing thrombotic thrombocytopenic purpura developed, manifested by thrombocytopenia and microangiopathic hemolytic anemia, and less frequently by neurological or renal abnormalities. Six patients had a second relapse, and two had five relapses. To assess the severity of the disease, a scoring system was designed based on the four major manifestations of thrombotic thrombocytopenic purpura listed above. The patients who died had a significantly higher score than those who survived. The initial episodes and the relapses of patients with relapsing thrombotic thrombocytopenic purpura were milder than those in patients who only had a single episode and survived. Two relapses, however, were fatal, demonstrating that relapsing thrombotic thrombocytopenic purpura is not a benign disorder. Infections, pregnancy and surgery were frequently associated with the initial episodes and the relapses. Hence, patients who recover from thrombotic thrombocytopenic purpura should be alerted to the possibility of relapse in association with these conditions.

Adult↗
PubMed1987

The function of food in residential treatment.

This paper describes the behaviour and backgrounds of adolescents in a therapeutic community and proposes that all experiences in the residential context need to form a single integrated psychotherapeutic process. Although reference is made to group and organizational issues, the central consideration is of the significance of food and its treatment potential in this total process.

Adolescent↗
PubMed1987

Recognition of a polymorphic monocyte antigen.

138 sera from renal transplant recipients were screened for the presence of monocyte-specific antibodies. Most of the sera contained antibodies against monocytes, T- and/or B-lymphocytes. One serum was identified which defined a monocyte-specific antigen, MOLI. This serum was investigated in intensive population and family studies for the estimation of the formal genetic criteria of this 'new' monocyte antigen. A gene frequency of 0.0614 was obtained by population analysis. Family investigations conveyed the information that the gene coding for MOLI was transmitted in linkage with HLA genes. A positive linkage disequilibrium of MOLI and HLA-B17 was found.

Antibodies↗
PubMed1987

Serology and genetics of human monocyte antigens (HMA system). Antibody, population and family studies.

This study was conducted for the purpose of detecting monocyte-specific alloantibodies by screening of sera which had been retroplacentally obtained, and with a view to delimitating their reactivity pattern from B and T lymphocytes. The data presented provide evidence for an unambiguous distinction of seven different monocyte antigens, MA-1 to MA-7. Segregation analyses of 14 informative families with 69 children revealed HLA-linked autosomal, codominant inheritance of these human monocyte antigen (HMA) via two gene loci (HMA-A and HMA-B) each of them with multiple allelism. The following gene frequencies were established: 0.1340 for HMA-A1; 0.0315 for HMA-A3; 0.0315 for HMA-A5; 0.0146 for HMA-A6; 0.0657 for HMA-B2; 0.0289 for HMA-B4, and 0.0614 for HMA-B7.

Alleles↗