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Biomedical subjects

M Rose

Publications and source records attributed to M Rose.

At least 217 records · Page 12Linked to original sources
PubMed1987

MHC antigen expression in sequential biopsies from cardiac transplant patients--correlation with rejection.

Class I induction on the myocardium of transplanted heart was investigated with regard to its temporal relationship to rejection episodes, how it is affected by anti-rejection therapy and whether it is dependent upon the presence of a T cell infiltrate in the biopsy. Sequential cardiac biopsies (total 114) from 11 patients from the time of transplant to 1 year after transplant were studied using immunocytochemical techniques. The effect of different immunosuppressive regimens on MHC antigen expression was also studied. All the biopsies diagnosed as showing rejection for the first time showed induction of Class 1 on the myocardium with 79% during subsequent rejection episodes. Class I induction was associated with a leucocyte infiltrate, not always containing T cells, and disappeared in 47% of biopsies taken 3-4 weeks after treatment with steroids and/or ATG. Increased expression of Class II, in particular DQ antigens on interstitial structures, paralleled Class 1 induction. MHC antigen expression returned to normal in 8/9 patients, at 1 year after transplant. Different immunosuppressive regimens affected the number of biopsies showing Class 1 induction on the myocardium. Our results suggest that in clinical heart transplantation class I induction is related to the rejection process.

Adolescent↗
PubMed1986

Long-term results with renal autotransplantation for ureteral replacement.

From 1970 to 1984 renal autotransplantation was performed on 23 patients to replace all or a major portion of the ureter. The conditions necessitating ureteral replacement were postoperative ureteral injury in 16 cases, recurrent renal colic in 4, urinary undiversion in 2 and an atonic ureter in 1. Six patients presented with a solitary kidney and 1 underwent staged bilateral autotransplantation. After autotransplantation urinary continuity was restored by ureteroneocystostomy in 11 patients, pyelovesicostomy in 7, ureteroureterostomy in 2, pyeloureterostomy in 2 and ureterosigmoidostomy in 1. Postoperatively, there was no mortality and all but 1 of the autotransplanted kidneys functioned immediately. Two kidneys required removal postoperatively owing to bleeding. Currently, 20 patients are alive with functioning renal autotransplants at intervals of 1.5 to 14 years. The current serum creatinine level in these patients ranges from 1.1 to 2.2 mg. per dl., which in each case is improved or stable compared to the preoperative determination. Only 1 patient has experienced chronic bacteriuria. We conclude that renal autotransplantation provides excellent long-term treatment for patients who require ureteral replacement.

Adult↗
PubMed1986

The design of atmosphere: ego-nurture and psychic change in residential treatment.

This paper concerns the very special nature of Peper Harow, a residential establishment for disturbed young people. The paper explores the means by which adolescents become absorbed in, and are helped to identify with, the goals of a therapeutic community, and draws on symbols and metaphors from literature to illustrate the treatment process. Examples are given from the life of the community, and attempts are made to capture the atmosphere of a unique establishment.

Adolescent↗
PubMed1986

Tissue-type plasminogen activator in breast cancer: relationship with estradiol and progesterone receptors.

Plasminogen activator (PA) is an estradiol-inducible enzyme and therefore a potential marker for a functional estradiol receptor (ER) in human breast carcinomas. In this investigation tissue-type PA (t-PA) correlated significantly with both ER and progesterone receptors (PR) in human breast carcinomas. In contrast, neither total PA activity nor urokinase-like PA showed any significant correlation with either ER or PR. Other proteases such as a trypsin-like protease, a chymotrypsin-like protease, and cathepsin B also showed no correlation with ER and PR. It was concluded that the t-PA form of PA may be a marker for a functional ER in breast carcinoma and thus be of value in predicting hormone-dependent breast cancers.

Breast Neoplasms↗
PubMed1985

Effect of bacterial products on prostaglandin E production by amnion cells.

An in-vitro model was set up to study a possible causal relation between bacterial colonisation of extraplacental membranes and spontaneous preterm labour. When amnion cells in tissue culture were exposed to bacterial products, their prostaglandin E output rose considerably. The degree of response varied with the organism. These findings support the theory that bacterial products may be responsible for the premature onset of labour.

Amnion↗
PubMed1984

Identification of a Ty insertion within the coding sequence of the S. cerevisiae URA3 gene.

Insertion mutations in yeast caused by the transposable element Ty have been identified at several genetic loci. In all cases so far, the site of Ty insertion has been in the 5' non-coding region of the affected gene. Experiments presented here demonstrate that the ura3-52 mutation, a non-reverting ura3 mutation, is caused by a Ty insertion mutation within the coding region of the URA3 gene. This Ty insertion within a gene has a similar structure to those in non-coding regions.

Base Sequence↗
PubMed1984

Modification of transoperative changes in blood fluidity by hydroxychloroquine: a possible explanation for the drug's antithrombotic effect.

A study was carried out in 40 patients undergoing minor surgery to investigate the effect of hydroxychloroquine on haemorrheological parameters which might explain its reported anti-thrombotic action. Twenty patients received 600 mg to 1400 mg hydroxychloroquine sulphate in the 48-hour period before operation and the control group of 20 patients received placebo. Blood samples were taken during the 24 hours before and on the day after operation. The results showed that in the hydroxychloroquine-treated group the transoperative increase in fibrinogen was associated with a reduction in plasma viscosity compared with an increase in the control group. Furthermore, the mean value for whole blood viscosity at middle shear rate decreased post-operatively in the drug-treated group whereas it increased in patients who had received placebo.

Blood Sedimentation↗
PubMed1984

[Results of embolization of spinal dural arteriovenous fistulas with perimedullary venous drainage].

From a group of 10 patients with arterio-venous meningeal fistulas of the dura-mater of the spinal cord, who where treated by embolization, the authors discuss and compare the results of this procedure to surgical management. This results, sometimes spectacular, are similar to surgical ones and sometimes better, essentially upon paresthesias and urinary troubles. They insist upon the interest of this management which appears often realizable in the same procedure than diagnostic angiography.

Adult↗