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Biomedical subjects

M Romano

Publications and source records attributed to M Romano.

At least 451 records · Page 25Linked to original sources
PubMed1981

[Influence of left ventricular volume changes induced by Valsalva maneuver on R wave amplitude (author's transl)].

Exercise-induced changes of R wave amplitude (delta R) during exercise has been employed to improve the reliability of stress testing in detecting patients with coronary artery disease. Several authors postulated that delta R are related to changes of ventricular volumes. Furthermore Valsalva Maneuver (VM) is able to induce a decrease of left ventricular volumes induced by VM and the variations of R wave. Echocardiographic method was used to determine left ventricular volumes and R wave amplitude changes were evaluated by Frank's lead. Our findings suggest that R wave amplitude changes are not related to variations of cardiac volume. Electrophysiological mechanisms of delta R need further investigation.

Adolescent↗
PubMed1981

[Effect of age on heart rate and systolic time intervals in children, adolescents and young adults (author's transl)].

Study was performed to assess if the increase of age can affect heart rate (HR) and systolic time intervals (STI) in a population of children, adolescents and young adults. We made polygraphic recordings in 66 normal subjects (5-25 years old) and regression equations were obtained for STI and age, HR and age and STI and HR. We found a significant relationship of HR and STI with age. Equally STI were correlated with HR. PEP/LVET ratio was unaffected by age or HR. We considered moreover mean values of HR and STI in four age-groups (5-10, 11-15, 16-20, 21-25). Data comparison showed higher LVET and lower HR in elder subjects. These had moreover higher PEP versus younger groups. The Authors believe that the relationship of HR, STI and age, undemonstrated by several other studies, can be found if we consider a large of age. Because other authors studied a little range of age, our demonstration of no statistically significant different values of HR and STI between 5-10 and 11-15 groups, authorize us to consider that the effect of age is highly significative on HR and STI among children, adolescents and young adults.

Adolescent↗
PubMed1981

Ultrastructure of Leydig cells in the testis of chicken submitted to early embryonic surgical bursectomy.

Different developmental stages of maturation in the Leydig cells in the interstitial tissue are described. The ultrastructure of Leydig cells in chickens submitted to early embryonic surgical bursectomy was compared to sham-operated controls. Subsequent quantitative studies in the testis of the 17.5 days old chick embryo and in newly hatched chickens showed a greater number of differentiated Leydig cells in the bursectomized animals as compared with controls. This phenomenon has been observed at both ages studied and is in agreement with the higher testosterone production previously described in the bursectomized chickens.

Animals↗
PubMed1980

Polyamines as biological markers of the effectiveness of therapy in acute leukemia.

Urinary polyamine levels were determined in patients with acute leukemia, before and during chemotherapy, in order to confirm whether tumor cell death, due to successful chemotherapy, increases the release in urine and serum of polyamines from tumor tissues (12). Comparison between the polyamine test and cytological data indicated that a rise in urinary spermidine levels occurs during the first 3 days of therapy, both in the responsive and unresponsive patients. However, in the responsive patients the spermidine increase was higher (at 5% significant level) than in the unresponsive ones, and it was coincident with the fall of the blast cells and the revival of normal hematopoiesis. Increases in putrescine levels were also observed, but there were no significant differences (5% level) between the 2 groups of patients. When polyamine determinations were carried out following chemotherapy cycles, the relapse of the disease was always accompanied by an increase in putrescine.

Adolescent↗
PubMed1980

[Use of biological prostheses for cardiac valve replacement in children and adolescents].

Between January 1976 and June 1980 a consecutive series of 13 patients aging from 9 to 18 years underwent cardiac valve replacement, out of 590 valve replacement operations. All had rheumatic heart disease and many had severe cardiac symptoms; all underwent cardiac catheterization and angiography before operation. Ten single valve replacements, 7 in the aortic, and 3 in the mitral position, and 3 double valve replacements were performed. All patients survived operation, except the one who died 2 months later for congestive heart failure. The others have been followed from 1 to 47 months, averaging 20,5 months. All are free of cardiac symptoms and are being treated with antirheumatic drugs. They are not anticoagulated after 6 months. The operative mortality is low in our bioprosthetic valve replacement, and we think that these operations are safely feasible.

Adolescent↗
PubMed1980

Isolation procedure for bovine retinal rod outer segments.

An isolation procedure to obtain rod outer segments from cattle retinas is reported. Centrifugation of homogenates in discontinuous and continuous sucrose density gradients yields purified photoreceptor cell outer segments. Assay of the final preparation for rhodopsin content gives a ratio of 2.4 for DO280nm/DO498nm.

Animals↗
PubMed1980

Exercise tolerance as evidence of quality of life in CAD patients after coronary artery bypass by comparison with medical treatment.

The effects of coronary artery bypass (CAB) by comparison with medical treatment were evaluated on exercise tolerance in 68 patients with stable angina on effort, who underwent coronary and left ventricular cineangiography. Stress tests were performed by bicycle ergometer before medical and surgical treatment, and 6 and 12 months thereafter. Thirty-five patients (31 males and 4 females; 7 with one 70% stenosed vessel, 12 with two, 16 with three) underwent CAB; 33 (30 males and 3 females; 9 with one 70% stenosed vessel, 11 with two, 13 with three), having refused CAB, only underwent medical treatment. Both groups were given long-acting oral nitrates, none received digitalis and/or propranolol; antiarrhythmic drugs were only administered in 5% of medical and 4% of surgical patients. Both groups at 6 and 12 months follow-up showed a significant improvement in exercise tolerance. Surgical patients showed a significant increase in exercise tolerance with lower angina incidence (from the preoperative 100% to 26% and 22%, respectively), higher work load (P < .001), and a significant reduction of S-T segment depression (P < .001). Medical treatment induced an increase of exercise tolerance; angina on effort decreased (from 100% to 74% and 72%, respectively) with higher work load, and a significant reduction of S T depression (in both cases P < .001). Comparing the data of the two groups, we observed that surgical patients showed higher exercise tolerance (P < .01), lower S-T depression (P < .001) and angina incidence. Our results suggest that surgical treatment is able to improve exercise tolerance more remarkably than medical treatment.

Adult↗
PubMed1980

[Combined valvular and coronary artery surgery (author's transl)].

Between January 1st, 1976 and October 31st, 1978 ten patients underwent simultaneour replacement or repair of a cardiac valve and coronary revascularization surgery. Six patients age ranged within 45 and 66 years presented mitral insufficiency, subsequent to myocardial infarction in five and rheumatic disease in one. Aortic valvular disease was present in four patients, it was atherosclerotic in three and congenital in one. All patients had both symptoms and signs of coronary insufficiency. Fifteen aortocoronary bypass grafts were inserted. Five mitral valve and four aortic valve replacements were performed; one patient underwent mitral valve annuloplasty. Best results were achieved in the aortic group, in which no deaths occurred; three deaths occurred in the mitral group. At the follow-up evaluation (average 14.2 months) all but one surviving patients showed marked symptomatic improvement, having moved to the upper functional class. The frequent incidence of coronary occlusive disease in patients with valvular heart disease recommends extensive use of selective coronary arteriography in preoperative evaluation. Simultaneous repair of all significant heart lesions is recommended.

Aged↗
PubMed1980

Left ventricular function after coronary artery bypass. Non-invasive study by systolic time intervals.

Left ventricular function was evaluated with serial recording of STI intervals in 78 patients with stable angina on effort undergoing coronary and left ventricular cineangiography. On the basis of these data the patients were divided into four groups: OV) nor or mild coronary disease (n. 11); 1V) 70% stenosed vessel; 2V) two significantly affected vessels (n. 32); 3V) three significantly affected vessels (n. 18). Thirty-six patients (9 with one stenosis, 17 with 2, 10 with 3) underwent coronary artery bypass. Thirty-one 8 with one, 15 with 2, 8 with 3) refused the treatment in spite of the same clinical situation and were medically treated. Recordings were performed before medical and surgical treatment and after 6 and 12 months. Initial average values of the patients of 2V and 3V groups showed a shorter LVETI, longer PEPI and higher PEP/LVET ratio than those of 1V and 0V groups. Subjects of 2V group and abnormal left ventricular wall motion showed longer PEPI and higher PEP/LVET than patients of 2V without abnormal wall motion. On first evaluation no differences were observed between surgical and medical groups. The latter did not show any difference after 6 and 12 months. Surgical patients of 2V and 3V showed a longer LVETI, shorter PEPI and a lower PEP/LVET than the medical group. In the surgical group PEPI and PEP/LVET were significantly decreased after surgery while LVETI was prolonged. Our results suggest an improvement of left ventricular performance by coronary artery bypass in patients with coronary artery disease.

Coronary Artery Bypass↗
PubMed1980

[Correlations between angiocardiography and changes of R wave amplitude during effort in patients with coronary heart disease (author's transl)].

The Authors studied correlations between angiocardiography and changes of R wave amplitude (delta R) during effort in 113 patients. They showed coronarographic evidence: 69 with stenosis greater than or equal to 70% of at least one major coronary vessel and 44 with no significant lesions. delta R values greater or equal than 0 were considered as pathologic. delta R appeared greater than or equal to 0 in 8 of 14 patients (57%) with single stenosis, 4 (28%) with abnormal wall motion (AWM). delta R increase or unchanged in 26 of 31 (84%) patients with double stenoses, 25 of them (81%) with AWM. delta R was greater than or equal to 0 in 22 of 24 (92%) with triple stenoses. In subjects with milk coronary artery disease (CAD) R wave increased or unchanged in 47% (19/44). Pathologic changes of R wave are highly frequent in CAD patients, especially in those with severe impairment. These changes, however, are not specific or costant because they appeared enough frequently in subjects with normal doronary vessels, and, moreover, R wave may decrease also in CAD patients with severe impairment. The Authors consider that evidence of delta R values greater than or equal to 0 may not be considered as a sign of CAD, but it must be evaluated with the other data showed by ergometric tests.

Adult↗
PubMed1980

[Diagnostic availability of R wave changes during effort test for a diagnosis of coronary artery disease (author's transl)].

New ecgraphic criteria has been proposed to improve diagnostic availability of R wave changes (delta R) and algebra summation of delta R and ST segment depression (delta RST) in comparison to the criterion of ST depression (ST). The AA. considered as a positive test for a diagnosis of coronary artery disease (CAD): delta R and delta RST values greater than or equal to 0. In 69 patients with stenosis, 75% of at least one major coronary vessel, delta RST showed correct diagnosis in 87% of cases, R in 81% and ST in 73%. RST sensitivity was better than that of ST (P = 0,02). In 44 patients with normal coronaries delta RST was able to correct diagnosis in 52% of cases, delta R in 57% and ST in 73%. ST specificity was better than that of delta RST (P = 0,04). Predictive accuracy was comparable for the three criteria. In normal healthy subjects everyone with an exercise test negative for CAD, with ST analysis, delta R and delta RST was 0 in 16% of cases. New ecgraphic criteria, also showing a better sensitivity in comparison with ST segment analysis, have a worsened specificity. The Authors do not consider these methods a significant improvement in ecgrahic evaluation of exercise test.

Adult↗
PubMed1979

DNA and oestradiol receptor distribution in human breast cancer.

The content of DNA and oestradiol receptors was measured in two different samples taken from the same tumoral mass of 33 primary infiltrating ductal carcinomas. The results were related to the total cytoplasmic protein and to the DNA of the tissue. The results showed that variations of both DNA and oestradiol receptors are frequent and often significant. The reliability of analyses carried out on a single biopsy is discussed.

Breast Neoplasms↗