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Biomedical subjects

M Romano

Publications and source records attributed to M Romano.

At least 433 records · Page 24Linked to original sources
PubMed1982

Perinatal development of cytochrome P-450, NADPH-cytochrome c reductase and ethoxycoumarin deethylase in rat liver nuclear membranes.

Perinatal development of rat liver nuclear membrane enzymatic activities was investigated with respect to the metabolism of xenobiotica. The qualitative pattern observed was very close to that reported for microsomal enzymes during development. Cytochrome P-450, NADPH-cytochrome c reductase and ethoxycoumarin deethylase are already present in fetuses at 18 days of gestational age. Phenobarbital pretreatment appears to be effective as an inducing agent for all the enzymes studied, but only after birth. The pattern of induction of cytochrome P-450 showed a peak at the 38th day of life three times higher than basal values at that age. NADPH-cytochrome c reductase presented a constant elevation to about twice basal activity throughout the period taken into consideration. Ethoxycoumarin deethylase activity took only 17 days to reach the basal value observed later in adult animals. This enzyme proved highly inducible by phenobarbital (5-fold) early after birth but the increase dropped to 3-fold from the 24th day of life.

7-Alkoxycoumarin O-Dealkylase↗
PubMed1982

Changes of systolic time intervals in asymptomatic patients with primary hyperlipoproteinemia.

Previous studies have focused on the usefulness of systolic time intervals to assess changes of myocardial function. In a recent report, hyperlipoproteinemia (HLP) was shown to induce early signs of vascular disease in asymptomatic subjects. By means systolic time intervals (STI) we studied left ventricular functions in normal subjects and asymptomatic patients with HLP, who showed normal response to exercise on a bicycle ergometer. The results showed mean values of STI for the population in the normal range, according to standards accepted in North American reports. Different values of STI were found when we compared the data of controls with the STI of HLP patients with higher values of PEPI and PEP/LVET and lower values of LVETI in HLP patients. These results suggest that hyperlipoproteinemia affects STI in asymptomatic patients, probably as a sign of early impairment of left myocardial function.

Adult↗
PubMed1982

[Influence of myocardial infarct on ventricular arrhythmias during the exercise test. Study in patients with stable angina of effort].

The incidence of ventricular arrhythmias observed during exercise (EVA) was correlated with the presence of previous myocardial infarction (IM) and angiographic severity of coronary artery disease (CAD) in 162 patients (pts.) with stable angina on effort, who had a positive stress test and greater than 70% stenosis of a major coronary artery. Our study population was divided in two groups: the first was composed of 95 pts. with previous MI, the second of 67 pts. without previous MI. Pts. of both groups were subdivided according to severity of CAD and to presence and degree of abnormal segmental wall motion (ASWM). In the MI group only 11.5% of pts. had single vessel disease, and 86.3% had ASWM. In pts. without MI 28.6% had single vessel disease; ASWM was found in 59.7% (p less than 0.001 vs MI pts.). Pts. with MI showed a higher incidence of EVA than pts. without MI (60% vs 32.8%, p less than 0.001). In both groups EVA were more frequent among pts. with double, triple vessel and main left CAD, than in pts with single vessel disease, but the difference was not significant. In general, EVA were found to correlate better with the number of areas with ASWM: in both groups significant differences of EVA frequency were found when pts. with normal left ventricular function were compared to those with more severe ASWM, while no difference was found between pts with and without MI who had the same degree of CAD. The most severe EVA (Tilkian's classification), were found in pts with a previous MI and a high ASWM score. In conclusion, our results show that a previous MI affects the development of EVA in pts. with stable effort angina. However EVA seem to be better correlated with the severity of LV impairment than with the extent of CAD.

Adult↗
PubMed1981

Levels of polyamines and nucleic acids in human breast carcinoma.

Polyamine and nucleic acid levels were determined in normal human breasts, in primary infiltrating ductal carcinoma breasts, in the uninvolved tissues of the same carcinoma-bearing breasts and in the urine of the same patients. The results showed that the production of polyamines in the carcinoma tissue is significantly higher than in normal tissue; the presence of a carcinoma in the breast does not modify the levels of polyamines and nucleic acids in the surrounding uninvolved tissue; spermidine and spermine are correlated both with DNA and RNA in the carcinoma; the urinary polyamine levels in the carcinoma-bearing patients were not significantly different from that of controls. There appeared to be a close relationship between polyamine biosynthesis and tumoral mammary cell development and a very fine control between the biosynthesis of both spermidine and spermine and nucleic acids. In addition, the localized solid breast carcinoma, with non-proven metastases, did not provoke an increase in polyamine excretion.

Adult↗
PubMed1981

Substituted 4,7-dihydroxyindoles and related quinonoid derivatives as potential antimicrobial agents.

The antimicrobial activity of some 4,7-dihydroxyindole derivatives and indole-4,7-quinones was examined by determining the MIC against selected typical microorganisms (bacteria and fungi). A few of the compounds examined showed only a feeble inhibitory effect against some Gram-positive strains. Activity seems to be correlated with the lipophilic character of the molecules; in fact, all compounds containing a strong hydrophilic group, like a carboxyl, proved completely inactive.

Anti-Bacterial Agents↗
PubMed1981

[The vectorcardiogram pattern of the athlete's heart (author's transl)].

In order to assess the vectorcardiographic pattern of the athlete's heart, we evaluated the vectorcardiograms of 17 professional footballers; the signs of ventricular hypertrophy were particularly studied. 9 athletes had left ventricular hypertrophy, 3 showed VCgraphic signs of combined ventricular hypertrophy and 5 had normal vectorcardiograms. In all athletes with left ventricular hypertrophy the initial forces had normal spatial orientation (I A left ventricular hypertrophy). Likely, the combined right ventricular hypertrophy explains these VCgraphic patterns. The QRS loop did not show abnormal morphology, only the high magnitude of the spatial maximum QRS vectors was significant for diagnosis of left ventricular hypertrophy. The increase of the cardiac volumes induced by training might explain the high magnitude of the QRS loop.

Adult↗
PubMed1981

[Serial evaluation by effort test of the effects of coronary artery bypass on effort angina (author's transl)].

To evaluate the duration of favourable effects of coronary artery bypass (CAB) on exercise-induced angina (A), 58 patients: 13 with single 21 with double and 24 with triple vessel disease, were studied. All patients underwent CAB for stable angina on effort. Patients underwent exercise testing (ET) before surgery at one, two and three years. Heart rate peak (HR), HR x systolic blood pressure peak (DP), work load (W), exercise-induced ST segment depression (ST) and incidence of A were evaluated; the results of ET before surgery were compared with those found after CAB. Our findings show that HR, DP, W and ST were significantly improved by surgery for at least 3 years. The lowest incidence of A was found at one year ET (20.6%), while it increased at two years (27,5%) and three years ET (37.9%). Most patients with A had angiographic evidence of left ventricular abnormal wall motion and ec-graphic signs of previous myocardial infarction. Our data indicate that serial exercise testing can objectively monitor the results of CAB. Most patients show an improved exercise tolerance for up to 3 years after CAB. Some patients, with more extensive CAD, showed a progressive deterioration of the clinical pattern and a decrease of the exercise tolerance.

Angina Pectoris↗