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Biomedical subjects

M Renoux

Publications and source records attributed to M Renoux.

At least 127 records · Page 7Linked to original sources
PubMed1977

Thymus-like activities of sulphur derivatives on T-cell differentiation.

Levamisole and sodium diethyldithiocarbamate can induce in vivo thymocyte differentiation from precursor spleen cells of nu/nu mice and evoke indirect plaque-forming cells in nude mice immunized with sheep red cells. These sulphur drugs induce in thymusless mice the production of a serum factor which transfer in vivo immune enhancement and in vitro thymocyte differentiation. In vivo treatment with sulphur derivative can substitute for an alleged thymice hormone.

Animals↗
PubMed1977

[Sodium diethyldithiocarbamate is a stimulating agent of immunity].

A single dose of DTC was administered, in a dose-range from 0.6 mg/kg to 25 mg/kg, to mice immunized with 10(8) sheep red cells (SRC). All doses strongly enhanced plaque-forming spleen cell (PFC) responses, when given either 18 h before, simultaneously to, 6 h or 24 h after SRC immunization. However, the higher levels of immunostimulation were attained by DTC doses above 5 mg/kg. DTC-induced immunopotentiation was not accompanied by untoward effects, such as acute toxicity, splenomegalia or modifcations in counts of viable spleen lymphocytes.

Animals↗
PubMed1977

Cerebromeningeal localizations in acute myeloblastic leukemia of the adult. Clinical and pathological study of 15 cases.

68 consecutive adults were treated for acute myeloblastic leukaemia (A.M.L). Involvement of the central nervous system (CNS) developed in 15 cases. The clinical characteristics of nine of these patients were: symptoms of increased intra-cranial pressure in 5, cranial nerve lesions in 4, peripheral nerve lesions in 5, cord compression in 1, hemispherical symptoms in 7. Lumbar puncture vas performed systematically on seven patients, two of them with evidence of meningeal leukaemia (M.L.). Post-mortem examination was performed on seven patients who died during the first induction treatment: three had evidence of C.N.S. involvement. M.L. developed in three patients during complete hematologic remission (R.C.) In patients younger than 60 years old, the incidence of M.L. was 8/24 (approximately 33%). Medial survival time was reduced:8 months in cases with M.L., compared to 13.5 months. Cerebro-fluid protein levels were increased in six cases without blast cells: in four cases, M.L. occurred within a few months. The frequency of meningeal leukaemia in A.M.I. is under-estimated. Eradication of this frequent complication is difficult. Prophylactic meningeal treatment may be instituted for patients younger than 60, to reduce the incidence of M.L. and to improve the median remission time.

Adolescent↗
PubMed1976

[Influence of the administration of levamisole on the reactivity of T-lymphocytes in advanced cancer patients].

The effects of levamisole were studied by evaluating T-cell responsiveness to a low dose of PHA on 31 advanced cancer volunteers. Treatment consisted in a 3-time a week oral administration of 150 mg of levamisole, actual time of observation is comprized between 10 and 31 months: 14 out of 31 treated metastatic cases of various solid tumours are still alive. In a group of 25 untreated patients, mean survival times were 65 days for men and 48 days for women. An increase of the responsiveness to a low dose of PHA was associated with survival, while death occurred when T-cells were unable to respond to the stimulatory activity of levamisole. These preliminary data confirm the paramount importance of cellular immunity in controlling neoplasias. They suggest a possibility to augment the life-span of cancer patients if an impaired cellular immunity machinery could be restored by the direct and indirect (hormonal) actions of levamisole, evidencing these mechanisms were still potentially functionning. They suggest also a monitoring of anti-tumoral immunity by evaluating the magnitude of T-cell response following levamisole administration.

Administration, Oral↗
PubMed1976

[Episodes of fever in the agranulocytic phase of the treatment of acute myeloblastic leukemia in adults].

This retrospective study of 44 attacks of fever during the agranulocytic stage of treatment of acute myeloblastic leukemia in adults, sought the cause of the fever, the efficacy of antibiotic associations and the efficacy of white cell transfusions. In 28 cases, the fever was associated with bacterial or mycotic infection, proved in 19 cases. Appropriate antibiotic therapy alone was able to cure the fever, whereas white cell transfusion did not seem of any use. In the 16 other cases, the fever appeared alone. Antibiotic associations were ineffective, whereas the fever was cured by white cell transfusions or cure of the agranulocytosis.

Adult↗
PubMed1976

Unclassified haemolytic anaemia with splenomegaly and erythrocyte cation abnormalities--a disease of the spleen?

An unclassified case of haemolytic anaemia with voluminous splenomegaly is reported. This anaemia was normocytic without any specific morphologic aspect of red blood cells (RBC); Coombs test was negative; the osmotic fragility was normal; the increased autohaemolysis was not affected by the presence of glucose; Hb studies were normal; no RBC enzyme deficiency was found; RBC lipids and membrane proteins were normal; there was a marked reduction in RBC survival with exclusive splenic uptake of erythrocytes. Before splenectomy, RBC cations and water content were abnormal: 1) the RBC water was decreased moderately; 2) the RBC sodium was about twice the normal mean with an increased 22Na turn-over; 3) the RBC potassium was markedly reduced and 42K influx was twice the normal mean; 4) the RBC calcium content was increased. Splenectomy was followed by rapid disappearance of haemolysis and RBC water and cation disturbances. Because of this extremely rapid disappearance after splenectomy the authors suggest this case of haemolytic anaemia could be a primary disease of the spleen.

Adult↗
PubMed1976

[Does local regional anesthesia exert an immunosuppressive effect?].

Lignocaine in very high doses exhibits immunodepressant properties in vitro. In vivo, in surgical patients submitted to spinal anaesthesia, lymphocyte transformation is diminished for one week. This inhibition is, however, less marked than after general anaesthesia.

Anesthesia, Conduction↗
PubMed1976

[Cachexia in mice induced by a fraction of Brucella melitensis. Modification by levamisole or by diethyldithiocarbamate of soda].

The PMF fraction of B. melitensis creates a wasting disease in newborn mice (J. infect. Dis., 1973, 127, p. 139). Administered to adult mice, PMF induces a 4 to 8 g loss of weight in 20 g mice and more markedly in males than in females. Treatment with Levamisole (LMS) suppresses this difference in response to PMF and restores normal weight in 24 days. Diethyldithiocarbamate (DDC), another immunostimulant sulfur derivate, abolishes the emaciating effect of PMF. Furthermore, DDC is an anabolizing agent which increases the weight of normal or PMF-treacted mice above the mean level of normal untreated control mice.

Animals↗
PubMed1976

[Mitogenic activity of Brucella fractions on cultured lymphocytes].

LPS from smooth B. melitensis extracted by the phenol-water method has no mitogenic activity for lymphocytes of men or mice uninfected by brucellosis, in amounts that are not toxic in vitro for these cells. Mitogenic activities of other B. melitensis fractions are evidenced only in amounts 100-fold greater than an effective dose of LPS from E. coli. We interpret these findings as reflecting a virgin immune status against brucella antigens.

Animals↗
PubMed1976

Potentiation of T-cell mediated immunity by levamisole.

Cell-mediated immunity is a requirement for recognition and elimination of cells and for prevention or treatment of a variety of diseases. Therefore, the development of a product potentially active in increasing immunity involves its testing in assays specific for cell-mediated immunity. The effectiveness of a single administration of levamisole was demonstrated in the rejection of isografts in a male to female C57BL/6 system, and on the enhancement of levels of the delayed type hypersensitivity (DTH) to sheep red cells (SRBC). Indeed, in five on nine tests, an injection of 25 mg/kg of levamisole to female recipients either on the day of grafting or 7 days after grafting resulted in a RT50% rejection time of 25 days, compared with 46 days in untreated controls. Levamisole administered at the time of immunization with various doses of SRBC elicited earlier, higher and more sustained DTH levels than in untreated controls. Such induction of T-cell activation was accompanied by a switch on anti-SRBC antibodies from IgM to IgG. These findings confirm and extend data evidencing the ability of levamisole to recruit and activate T cells for an increased or restored cell-mediated immunity.

Animals↗
PubMed1976

[Biological properties and chemical composition of a soluble fraction of Brucella abortus. Monospecific A or M antigens].

ABS, the supernatant of smooth B. abortus phenol-protected suspensions, is a protein, lipid, sugar and ARN complex containing all amino acids found in phenol-water fractions from B. abortus and B. melitensis. ABS is non-toxic and immunizes mice against B. abortus challenge. Chromium chloride easily binds ABS to sheep erythrocytes (E ABS) for a specific and accurate passive hemagglutination test in brucellosis. E ABS are agglutinated by all antisera to fractions of B. abortus or B. melitensis, but not by the monospecific anti M serum. A study of the antigenic relationships between ABS and phenol-water fractions from smooth brucella strains leads to the isolation of sub-fractions fron the phenol precipitates of B. abortus or of B. melitensis that could contain only A or M antigens which react only with their respective monospecific A or M serum.

Amino Acids↗