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Biomedical subjects

M Renoux

Publications and source records attributed to M Renoux.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Cerebro-meningeal involvement in acute myeloblastic leukaemia and myeloproliferative syndromes in acute transformation. Cytological, histological and clinical study of 62 cases (author's transl)].

Clinical and histopathologic study of central nervous system (CNS) was performed in 46 acute myeloid leukemia (AML) and 16 chronic granulocytic leukemia in the blastic phase (CGL). Involvement of the CNS developed in 28 cases. Eighteen patients out of these 28 had neurological symptoms. The frequency of meningeal leukemia depends on the number of lumbar punctures and on the survival time. Post-mortem examination was performed on 45 patients. Eighteen had evidence of CNS leukemic infiltration (18/45 arachnoid, 10/31 dura, 5/45 brain). Hemorrhages are frequent even without CNS involvement (19/27). CNS leukemic infiltration is common enough in AML and CGL to justify agressive diagnostic, therapeutic, and prophylactic measures.

Arachnoid↗
PubMed1979

Genetic and epigenetic control of levamisole-induced immunostimulation.

Antibody responses to a T-cell dependent antigen, sheep red blood cells, were evaluated in mice of various inbred strains, treated or untreated, with levamisole. These responses appear to be under polygenic control, not associated with the H-2 complex, and modified by a Y-linked component and epigenetic factors revealed by aging. Strain, sex, age and the dose of levamisole all in influenced in an interrelated manner the activity of levamisole. Effects varied from inhibited to unchanged or increased antibody-forming cell numbers, without a direct relationship between the genetic regulation of levamisole effectiveness and a genotypic capacity to respond to the antigenic signal. Therefore, a complex relationship between host, antigen and immunopotentiator appears to be responsible for modifying the production of suppressor or helper influences. The present findings may serve as a warning against the uncritical use of levamisole.

Animals↗
PubMed1979

Immunopotentiation and anabolism induced by sodium diethyldithiocarbamate.

Sodium diethyldithiocarbamate, DTC, enhances over a large range of doses macrophage listericidal capacity and T cell activities in terms of increased IgG-antibody forming spleen cells and delayed hypersensitivity levels. Such immunopotentiation is not associated with splenomegalia or increase in lymphocyte counts. Immunopotentiation requires a preexisting link between carbon disulfide and diethylamine, since both moieties were inactive if administered alone or on separate body sites. DTC demonstrates also an anabolic effect on mice emanciated by administering a B. melitensis cell-wall fraction. The role of DTC on hormonal production is discussed in relation to hormone-mediated action on T cell induction.

Adjuvants, Immunologic↗
PubMed1979

Isoprinosine as an immunopotentiator.

Isoprinosine is a compound developed for antiviral use. The effects of isoprinosine on mouse responses to sheep red blood cells were studied over a wide range of doses, from 0.5 microgram/kg to 5 g/kg, i.p. administered at the time of i.v. immunization or as pretreatment for 7 days before antigenic stimulus. Low doses, 50 microgram/kg to 50 mg/kg, significantly increased the numbers of IgM- or IgG-spleen antibody-forming cells. Large doses, such as the LD50 (5 g/kg) or pretreatments where unable to impair mouse immune responsiveness. Isoprinosine (< 500 mg/kg/day) orally administered at time of or one day after immunization stimulated immune responses. In vitro addition of isoprinosine to spleen lymphocytes augmented PHA- or Con A-induced proliferation over a concentration range from 10 to 150 microgram/ml, whereas isoprinosine had no effect in the absence of mitogens. These data, and the lack of immunodepressing effect, suggest that there is a need for further evaluation of isoprinosine as an immunopotentiator.

Adjuvants, Immunologic↗
PubMed1979

Differentiation and regulation of lymphocyte populations: evidence for immunopotentiator-induced T cell recruitment.

Isoprinosine, the p-acetaminobenzoic acid salt of inosine dimethylaminoisopropanol (1:3 molar ratio) and sodium diethyldithiocarbamate are two immumopotentiators which share an ability to induce in vivo acquisition of a specific T-cell marker by undifferentiated precursor lymphoid cells of healthy nu/nu mice, without affecting the B-cell lineage. Serum from treated nu/nu mice tested in dual assays, contains a selective inducer of prothymocytes.

Adjuvants, Immunologic↗
PubMed1978

[Angioimmunoblastic lymphadenopathy and Prurigo strophulus (author's transl)].

Angio-immunoblastic lymphadenopathy (A.I.L.) was classified as a special type of malignant lymphoma. However, the same morphologic features can be observed in non-malignant diseases. We report a case of A.I.L. associated with Prurigo Strophulus: pseudo-tumoral adenopathy and cutaneous involvement disappeared with parasiticide treatment.

Aged↗
PubMed1978

[Targets and mechanisms of levamisole-induced immunostimulation (author's transl)].

Levamisole modify the functions of neutrophils, of macrophages and of T-cells in normal, healthy men and animals. Hormone-like products are synthetized after levamisole administration, even in athymic mice, to recruit T cells from precommitted precursor cells and to activate mature T cells. Levamisole-induced immunostimulation is associated with activities of its sulphur moiety more than with cholinergic properties of the imidazole moiety. Levamisole activities are modulated by genetic and environmental factors and by the degree of antigenic stimulus. Immunostimulation by levamisole depends upon individual responsiveness. Practical usefulness of levamisole therapy will be optimal if acquired experimental findings are taken in account to determine the schedules of treatment.

Animals↗