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Biomedical subjects

M Renoux

Publications and source records attributed to M Renoux.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Passive hemagglutination, lymphoblastic transformation, and leukocyte migration applied to the diagnosis of brucellosis].

Passive hemagglutination test (HP) after binding of ABS antigen to SRBC by chromium chloride, lymphocyte transformation (TTL) and inhibition of leukocyte migration (TML) tests were compared to tube agglutination and complement fixation tests, and to clinical symptoms for diagnosis of brucellosis. Both TTL and TML persist for years after contact with brucella. HP is the most reliable serologic test.

Antibodies, Bacterial↗
PubMed1975

[Diagnosis of human active or latent human brucellosis by lymphocyte transformation. Inhibition of leukocyte migration and passive hemagglutination. Possible interference between brucellosis and some mental disorders].

Passive hemagglutination tests (H.T.), involving the coating of a soluble B. abortus antigen onto sheep red blood cells through chromium chloride, were always negative in non-brucellic subjects. Positive H.T., even at low titers (1:50), were associated with positive specific lymphoblastic (T.T.L.) and inhibition of leucocyte migration (I.M.L.) tests in 13 patients. These 3 tests were negative in 17 control brucellosis-free individuals. Positive H.T. confirmed a clinical diagnosis of brucellosis in 27 patients with dubious or negative responses to classical tests. Low positive (1:50, 1:100) H.T. may correspond to Brucella primary-infection or to a quiescent chronic infection, and higher titers to clinically active brucellosis. There is a correlation between cellular immunity tests (T.T.L., I.M.L.) and passive hemagglutination test. Furthermore, 39/88 women hospitalized in psychiatric wards were positive to H.T., and 6 of them were also highly positive to complement fixation and tube agglutination tests. Three T.T.L. and I.M.L., performed on samples from 3 H.T. (1:50) positive patients, were positive. These 30 patients were classified as depression or severe anorexia.

Adult↗
PubMed1973

Stimulation of anti-Brucella vaccination in mice by tetramisole, a phenyl-imidothiazole salt.

The effect of tetramisole (hydrochloride of racemic 2, 3, 5, 6,-tetrahydro-6-phenyl-imidazo [2, 1-b] thiazole) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant. Immunity to Brucella abortus challenge was estimated by the reduction in number of B. abortus colonies per gram of spleen in those mice which escaped full immunization and also by calculation of mean infective doses for each group of mice. All tetramisole treatments significantly reduced the number of B. abortus live cells in spleen from infected mice. Tetramisole, injected twice (at the time of vaccination and 48 h later), induced a significant 3.5-fold increase of the protection brought about by Brucella vaccine alone. A single injection of 1.25 mg/kg at the time of vaccination resulted also in a significant increase of the immunity given by vaccination. No modifications of the vaccine potency were observed if tetramisole administration preceded vaccination. In such a mouse assay, tetramisole-induced stimulation was not accompanied by specific antibody increases, although measured by three serological tests.

Antibodies, Bacterial↗