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Biomedical subjects

M Renoux

Publications and source records attributed to M Renoux.

At least 91 records · Page 5Linked to original sources
PubMed1983

Sodium diethyldithiocarbamate (imuthiol) and cancer.

Sodium diethyldithiocarbamate (imuthiol), a nonantigenic, nontoxic and noncarcinogenic compound, evinces distinctive properties in recruitment and activation of T cells, and no direct influences on B cells or macrophages. The biological attributes of imuthiol (destruction of neoplastic cells, bacteria, fungi and parasites; a detoxifying influence against carcinogens or agents toxic for the liver) could strengthen its activity as a biological response modifier. Preliminary clinic testings show that imuthiol restores T cell activities and regulates the ratio among T cell subsets in cancer patients, without untoward side effects.

Animals↗
PubMed1983

A balanced brain asymmetry modulates T cell-mediated events.

Partial ablation of the left fronto-parietal cerebral cortex decreases the number of spleen T cells, impairs IgG-alpha SRBC and T mitogen-induced responses, and delays the response to alloantigens. In contrast, these events are increased following a symmetric lesion of the right neocortex. The findings extend previous results showing that the neocortex modulates NK activity and the efficacy of T cell-specific serum factors. B cells and macrophages are not affected. In these assays, mice subjected to ablation of one lateral cerebral neocortex serve as controls for symmetrically lesioned mice, in addition to no surgery or sham-operated controls. The findings suggest that brain lateralization for cognitive processes should be extended to T cell immune recognition. The phenomenon is present at a population level.

Animals↗
PubMed1983

The production of T-cell-inducing factors in mice is controlled by the brain neocortex.

The synthesis of factors that monitor the expression of the Thy-1 cell surface component by marker-negative precursor cells requires an intact left cerebral cortex, whereas the activity of sodium diethyldithiocarbamate, an immunopotentiator that increases this synthesis, seems to require an intact right neocortex. These results suggest a role for the cerebral cortex in the coordinated interregulation of lymphocyte subclasses. The finding extends previous information suggesting relationships between the central nervous system and the T-cell arm of the immune system.

Animals↗
PubMed1983

Sex-associated relationships between cell counts and lymphoproliferative responses in healthy young adults.

Correlation analyzes of lymphoproliferative responses, total T (E-rosettes) cell levels and autologous rosette-forming cell (A-RFC) levels of healthy human volunteers revealed previously unsuspected sex-associated differences. A negative association existed between response to Con A and E-rosette levels in men, and between PHA lymphoproliferation and E-rosette counts in women, whereas mitogen-induced responses and A-FRC levels varied independently in either sex. Total T cell and A-RFC counts correlated only in man.

Adult↗
PubMed1982

[Synovial folds of the knee (plica synoviales). Treatment under arthroscopy].

The authors report on synovial folds of the knee examined by arthroscopy. 60 arthroscopies in 59 patients showed a plica synoviale. The authors recount the different anatomical types. A suprapatellar plica is found in all the cases and a lateropatellar plica is found in 7 out of 60 cases. The suprapatellar plica forms a fibrous fold which is sometimes completely folded off (6.6%) but more often it is an incomplete fold: internal (66.6%), external (21.6%) or annular (15%). In some cases arthroscopy reveals cartilaginous lesions associated with the plica. 18 patients out of 37 showed lesions of secondary chondromalacia. Endoscopic resection offers a possibility of treatment for this condition. The results of this operation were good or excellent in 64.7% of the patients without cartilaginous complications and in 40% of the patients who had a lesion of their cartilages. In the discussion the authors present the possible physiopathology of this syndrome and the presenting symptoms.

Arthroscopy↗
PubMed1980

[Acute agranulocytosis. Clinical study of thirty-two cases (author's transl)].

Acute agranulocytosis is a serious accident if the nature of the accident and the responsible drug are ignored or if it happens to a weak patient. Among thirty two cases of hospitalization, probably chosen according to their seriousness, the authors recall the diversity of the symptoms, the risk of the abuse of the "pyrazol compound" (70% of agranulocytosis) and the frequency of relapse (30%). The prognosis depends on the risk of infection. Septicemy is rare (15%), often foreseeable depending on the state of the patient. Agranulocytosis remains serious in spite of a wide range antibiotics administered in the early stages.

Acute Disease↗
PubMed1980

[The cerebral cortex regulates immune responses in the mouse].

Ablation of the left cerebral cortex abrogates the production of thymic hormone, reduces the number of spleen T cells and impairs immunization with sheep erythrocytes. In addition, partial decortication inhibits the ability of sodium diethyldithiocarbamate (DTC) to increase the level of circulating thymic hormone, as well as the number of splenic T cells. Therefore, the cerebral cortex would display an important role to maintain body integrity and relations with the external environment, through its effects on the immune system.

Animals↗
PubMed1980

A passive hemagglutination test for the detection of Brucella infection.

An improved method of coupling a soluble complex, ABS, isolated from B, abortus to sheep red blood cells by chromic chloride in the presence of barbital buffer resulted in a highly specific and reliable passive hemagglutination test for the diagnosis of human and animal brucellosis. No false positive results have been found so far in more than 2000 control sera from known brucellosis-free patients or animals. On the other hand, with over 1800 test sera from patients or animals with Brucella infections, there were no false negative results, in contrast with tube agglutination or complement fixation tests.

Animals↗
PubMed1980

Induction of differentiation of human null cells into T lymphocytes under the influence of serum of mice treated with sodium diethyldithiocarbamate.

Mouse serum collected 24 hr after administration of sodium diethyldithiocarbamate was shown to convert a subset of null cells, not bearing the human T lymphocyte differentiating antigen (HTLA cells) into HTLA+ cells in man. In addition to inducing surface characteristics of T lymphocytes, the serum of treated mice increased functional activities of human peripheral blood lymphocytes, including the response to Con A and the suppressor activity in vitro.

Animals↗
PubMed1980

Administration of DTC gives evidence of a role of the thymus in the control and regulation of factors inducing thymocyte differentiation in the mouse.

Nude (B6) mice, grafted with a syngeneic thymus, are treated 3 wk later with 25 mg/kg of sodium diethyldithiocarbamate (DTC). Serum sampled 24 h afterwards is heated at 56 degrees C for 45 min and tested over a large range of doses for its in vitro capacity to induce Thy-1+ cells in nu/nu spleen cells. Data are compared with the effects of DTC on ungrafted nude mice, and on B6 and C3 mice. Each group comprised 5 to 6 animals. The thymus of B6 mouse abrogates the action of DTC to induce in thymus-less mice two serum factors, active at different concentrations. The serum of DTC-treated C3 mice has an increased T-cell recruiting activity in contrast with the serum of DTC-treated B6 mice. The findings are interpreted as evidencing the extra-thymic origin of one active factor, and a role for the thymus to regulate the synthesis of both factors.

Animals↗