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Biomedical subjects

M Popescu

Publications and source records attributed to M Popescu.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

[Therapeutic management of fracture-induced osteitis].

Fractural osteitis is considered to be exclusively of external origin, being due either to accidental wounds, or to operatory wounds. The infection is usually either with a single strain of germs, or with a small number of strains, most frequently a staphylococcus strain with a necrototizing effect on the bone structure. The prophylaxis has a determinant role, and the authors stress the organisatory measures, as well as the medical attitudes that should prevail in the face of an open fracture. In the case of closed fractures that have been infected as a result of surgery the necessity for an "early reintervention" is stressed. Late postoperative osteitis may develop in a consolidated focus, and is called osteitis of the repaired bone. It may also develop as an osteoarthritis or, and this is more serious, as a suppurated pseudarthrosis. The therapeutic attitude depends on the condition, and may consist in the removal of the osteosynthesis material, removal of the sequestered bone tissue, a so-called: "mis-à-plat" of the cavity with muscular tissue and application of septopal pearls, or a two-stage spongious graft according to Papineau, under protection of the external fixation when the necessity arises.

Fracture Fixation↗
PubMedDate not supplied

Drug allergy: incidence in terms of age and some drug allergens.

The authors studied the incidence of drug allergy in 3 groups of subjects. In the first group the incidence was established in terms of the subjects' age: 1.8% in children up to 14 years old (323 subjects), 5.8% in middle-aged subjects (389 subjects) and 2.9% in the elderly (243 subjects). In the second partly selected group, drug allergy was studied in patients admitted to the 3rd Medical Clinic--Craiova between 2 Jan. 1981 and 31 Dec. 1982; 103 of the 8,760 patients admitted presented allergic reactions, a relatively high incidence rate (1.01%) as compared to other published reports. The third group of previously selected cases consisted of 197 patients who had come to the allergology service with complaints of present or past sensitivity to drugs. The total number of patients was 336 selected or preselected from about 10,000 subjects, to which 17 patients with a diagnosis of "asthmatic triad" must be added. Drug allergy in terms of the drug used was dominated by penicillin, pyramidon-algocalmin, aspirin, iodine preparations, etc.; foremost among the clinical syndrome were the dermatologic syndromes types I, III and IV; syndromes of the "anaphylactic shock" type, "serum sickeness" bronchial asthma, angioneurotic oedema.

Adolescent↗
PubMedDate not supplied

The frequency of allergens implicated in bronchial asthma in different areas of Romania.

The study carried out on 582 asthma patients and 164 healthy controls, ranging in age from 5 to 60 years, dwelling in four different towns ( Sibiu , Mediaş, Baia Mare, Sighetul Marma tiei ) showed that the most frequently involved antigen in allergic bronchial asthma was house dust (50.3 to 86%), followed by Dermatophagoides pteronissinus and atmospheric fungi, and the most frequently encountered associations were likewise between these allergens, hence the orientation towards a specific hyposensitizing therapy. In these localities with a rich gramineous vegetation there was a high per cent of sensitization to the polen of these plants. Sensitization to woollen hairs has been reported in a high percent in the region of Maramure ş and is linked to its ethnical characteristics. In many cases the patients also exhibited hypersensitiveness to bacteria, associated with environmental allergens, the vicious circle realized by an allergic-infectious mechanism being known. The conclusions of the study on the etiology of bronchial asthma in these geographical areas will be used as a basis for the treatment and its orientation.

Adolescent↗
PubMedDate not supplied

The relationship zinc--alkaline phosphatase activity in normal and pathologic granulocytes.

To study the relationship granulocyte alkaline phosphatase (AP)--zinc (Zn) in mixed leukocyte suspensions, the enzyme from 51 mixed leukocyte suspensions was separated and purified. In the pure extract, determinations were carried out for enzymatic activity--using the autoanalyzer LKB 8600--and for Zn content--using atomic absorption spectrophotometry. From the data obtained it resulted that, in agreement with the results in the literature Zn concentration in the mixed leukocyte suspensions from chronic myeloid leukemia, (CML) patients is about half that in the normal controls (0.65 +/- 0.15 as compared with 1.24 +/- 0.15 micrograms/mg total nitrogen). Granulocyte AP separated from normal leukocyte suspensions was found to bind about 95% of the total Zn content, i.e., 1.21 +/- 0.15 micrograms/mg total nitrogen and its enzymatic activity was about 16 U/g total nitrogen. In CML patients the enzyme bound a mean Zn concentration of 0.55 +/- 0.15 micrograms/mg total nitrogen and its mean activity was 2.25 U/g total nitrogen, i.e., about 86% of the normal values found in the controls. The enzymatic activity decreased to zero after only 20 min dialysis with 8-hydroxyquinoleine-5-sulfonic acid (8HC5S) as compared with the 60-80 min in the controls. It can be concluded that the leukemic leukocyte is unable to form the metal-enzyme complex owing to the deficit of the Zn involved in the enzymatic activity.

Alkaline Phosphatase↗
PubMedDate not supplied

Alkaline phosphatase activity improved by the addition of zinc in granulocytes from leukemic subjects (in vitro study).

Granulocyte alkaline phosphatase (GAP) was extracted from the leukocyte suspensions of 15 subjects with chronic myeloid leukemia (CML), determining the Zn content by atomic absorption spectrophotometry. The purified enzymatic preparation was dialyzed against a ZnCl2 solution (.01 mg%) in TRIS-HCl 0.1 M, pH 7.5, for 48 hours. After dialysis Zn concentration and GAP activity reached normal values. This suggests that the GAP molecule isolated from CML subjects is not altered as it is able to receive at most 2 Zn moles responsible for the enzymatic function.

Alkaline Phosphatase↗
PubMedDate not supplied

Endocrine circadian time structure in the aged.

Thirteen circadian rhythms in plasma hormone levels (ACTH, aldosterone, cortisol, C-peptide, insulin, DHEA-S, estradiol, LH, prolactin, 17-OH progesterone, testosterone, T4 and TSH) were studied in April 1981 in 25 males and 25 females 57 to 91 years of age, institutionalized at the Berceni Hospital for the aged. The radioimmunoassays and the statistical rhythmometric evaluation by the cosinor procedure were done at S. Paul-Ramsey Medical Center, St. Paul, MN, USA. Circadian rhythms were found and quantified for each of these variables. Elderly subjects of both sexes thus maintain a circadian time structure of their endocrine system as a group phenomenon. In comparison with previous data from the Endocrine Rhythms Laboratory ("C. I. Parhon" Institute) and series of younger subjects studied in Minnesota (St. Paul-Ramsey Medical Center) as well as in comparison with data published from other centers, the aged seem to experience an earlier arousal of their endocrine system which may be related to certain disturbances of old age e.g. of sleep. The latter observations will have to be confirmed by additional studies which take both circadian and circannual variations in account.

Age Factors↗
PubMedDate not supplied

Pathogenesis aspects of arthrosis in histopathological and electronmicroscopical studies of articular cartilage, correlated to some immunological parameters.

Twenty-five biopsies of arthrosic cartilage with radiological correspondence, arthro, sic cartilage under study for Rheumatoid Arthritis (RA) and posttrauma cartilage as control-were examined using histopathological (HE, VG, PAS-Alcian, Gömöri, Safranine O) and electronmicroscopical techniques. The arthrosic cartilage with radiological correspondence shows superficial and deep fissures, perichondrocytic gaps and modified reticulino-collagenic network at the histopathological examination. At the level of synovia-cartilage junction, we found some villous aspects of the synovia desquamating in the proximity of the affected cartilage. The investigated arthroses for RA presented some destructive fibrous modifications of the synovia similar to rheumatoid synovitis and associated with some dystrophic chondrocytic alterations. The ultrastructural affection was severe leading to cellular degeneration. The immunologically-studied arthroses for RA had seric pathologic values regarding: circulating immune complexes (CIC) (mean = 67.08 +/- 1.45 U), Ig.M(mean = 358 +/- 3.02 UI/ml) and anti collagen antibodies (mean = 409.9 +/- 0.42 U). The synovial depletion of complementary fraction C3(mean = 42.3-1 mg%) as against the normal seric level (mean = 63.07 +/- 0.49 mg%) suggests an immune synovitis. Correlation of immunomorphopathological data emphasize that arthrosis coexists with a secondary synovitis following a primitive degenerative process and allows arthroses under study for RA to be separated from other degenerative rheumatism diseases.

Antigen-Antibody Complex↗
PubMedDate not supplied

[The atypical ophthalmologic onset of acute Devic neuromyelitis].

A case of Devic's acute neuromyelitis with an atypical ophthalmic debut is presented. Usually, the Devic's neuromyelitis starts by concomitant alteration of both eyes. In the described case, the condition debut has been monocular (OD), as a juxtabulbar optic neuritis, after a respiratory viral infection. The neurological syndrome (paraplegia) and the acute renal failure appeared one week after the viral debut, the patient having been transferred to the neurology department, where, under cortisone treatment the ophthalmological phenomena disappeared completely, remaining only the neurological condition (tetraplegia).

Acute Disease↗
PubMedDate not supplied

[Rubella pigmentary pseudoretinopathy].

Two cases of rubeolic pigmentary retinopathy with multiples anomalies at congener eye are presented. Both two cases present at congener eye microphthalmos and congenital cataract with uveitis in the first case and convergent strabismus and retard psychomotor in the second case. The retinal lesions are disseminated in all retinal surface in one observation, and only in the temporal retinal area in the second one. These retinal lesions associated with other ocular anomalies are characteristic for rubeolic etiology.

Abnormalities, Multiple↗