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Biomedical subjects

M Otani

Publications and source records attributed to M Otani.

At least 145 records · Page 8Linked to original sources
PubMed1980

Mycinamicins, new macrolide antibiotics. I. Taxonomy, production, isolation, characterization and properties.

Mycinamicins, novel macrolide antibiotics were obtained from the culture broth of Micromonospora grisseorubida sp. nov. Isolation of five components, mycinamicins I, II, III, IV and V, was accomplished by silica gel adsorption or partition chromatography. Mycinsmicin I and II exhibit a strong UV absorption peak at 218 nm and have a shoulder at 240 nm. Mycinamicin III, IV and V show strong UV absorption peaks at 215 nm and around 280 nm. From their physicochemical and biological properties, the mycinamicins are classified as new macrolide antibiotics.

Anti-Bacterial Agents↗
PubMed1980

Studies on the absorption, distribution, metabolism and excretion of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[(4-hydroxyphenyl)isopropylamino]-ethane hydrobromide (Th 1165 a, fenoterol hydrobromide) in mice.

Absorption, distribution, metabolism and excretion of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[(4-hydroxyphenyl)-isopropylamino]-ethane labelled with 3H (3H-fenoterol) were investigated in mice. After oral administration, 3H-fenoterol was absorbed quickly, reaching a maximum concentration level within 0.5 h after administration, and decreased thereafter with a half-life of about 2 h. Concerning the distribution in tissues after oral administration, digestive tracts showed the highest radioactivity concentration, with lesser concentrations in the kidneys, trachea and liver. The radioactivity concentrations in the other tissues were lower than or equal to that in blood. The concentration in brain tissue was especially low. 24 h after administration, radioactivity was hardly observed in any of the tissues except for intestinal contents. The rates of excretion in urine and in feces in 72 h were ca. 81% and 16%, respectively, with i.v. administration and ca. 45% and 45%, respectively, with oral administration. Metabolites were investigated in urine, serum, liver and kidneys. With every sample the mother compound was hardly observed at all, and most of what was observed were conjugates of fenoterol. The binding rate of 3H-fenoterol with serum protein was investigated with a gel-filtration method. As a result, the binding rate with serum protein was 3--5%.

Animals↗
PubMed1979

Effect of alanine-containing dipeptides on germination of Bacillus thiaminolyticus spores.

Stereoisomeric alanylalanine (Ala-Ala) derivatives were examined for their effects on germination of Bacillus thiaminolyticus spores. L-Ala-L-Ala and L-Ala-glycine were effective in inducing germination, and their activities were completely inhibited by D-Ala. L-Ala-D-Ala and glycine-D-Ala competitively prevented L-Ala-induced germination. Sarcosine- or beta-Ala-containing L-alanyldipeptides and eight kinds of alanyltripeptides did not show any detectable effect on germinability or any inhibitory effect. No detectable amounts of Ala were found in germination exudates when alanylpeptides were incubated with spores. The ability of these peptides to induce or inhibit germination depends on their steric conformation and a certain distance between the primary amino group and the free carboxyl groups. Involvement of L-Ala dehydrogenase in the initiation of germination is unlikely because L-Ala-L-Ala was not a substrate and L-Ala-D-Ala was not an effective inhibitor of enzyme activity.

Alanine↗
PubMed1978

Stability and the biological activity of eel calcitonin in rats.

Hypocalcemic effect in rats of eel calcitonin was more persistent that that of porcine calcitonin and it was as persistent as that of salmon calcitonin I. Eel calcitonin was more stable than porcine or salmon calcitonin I when incubated in vitro with rat or human serum. Incubation in vitro with rat kidney or liver extract for 1 hour at 37 degrees C caused an almost complete inactivation of porcine calcitonin. On the other hand, both eel and salmon calcitonin I were inactivated less markedly and in the similar manner. The relationship between the hypocalcemic effect of calcitonins and the inactivation is discussed.

Animals↗
PubMed1978

[Synergistic effect of ampicillin and dicloxacillin on penicillin and cephalosporin-susceptible Escherichia coli (author's transl)].

An effect of a combination of ampicillin (ABPC) and dicloxacillin (MDIPC) on penicillins and cephalosporin-susceptible E. coli was determined. Minimum inhibitory concentrations of the combined drug were as same as that of ABPC, but bacterial growth was inhibited by the combined drug stronger than ABPC, low activity of beta-lactamase was detected in sonicated E. coli 0.225 cells, and this activity was inhibited by relatively low concentration of MDIPC. We considered that a weak synergism of the combined drug might attribute to the inhibition of the beta-lactamase activity by MDIPC.

Ampicillin↗