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Biomedical subjects

M Nitzan

Publications and source records attributed to M Nitzan.

At least 73 records · Page 4Linked to original sources
PubMed1988

Assessment of regional blood flow and specific microvascular resistance in the foot by means of the transient thermal clearance method.

Measurements of skin blood flow have been made in a group of 34 patients presenting with symptoms of peripheral vascular disease. Of the patients, 18 were non-diabetic and the remainder diabetic. Measurements of blood flow were made using the transient thermal clearance method, and of systolic blood pressure in the dorsalis pedis artery using a CW ultrasonic Doppler blood velocimeter and an occluding cuff. There was no difference in pressure index between the two groups. Neither a linear pressure/flow relationship nor the presence of autoregulation was demonstrated. The derivation of specific vascular resistance (SVR) for the two groups shows that in the diabetic it was 7.07 +/- 2.2, while in the non-diabetic it was 11.12 +/- 3.9. The difference is significant (P less than 0.005) and suggests that measurement of SVR may be useful in the differential diagnosis of vascular disease.

Blood Pressure↗
PubMed1988

Determination of blood gases in children with extreme leukocytosis.

The effect of extreme leukocytosis (greater than 300,000/mm3) on the PaO2 of blood stored at 22 degrees and 2 degrees C was studied in two children with leukemia. Arterial blood samples drawn from these patients at 1 and 10 min were compared to blood samples drawn from eight control patients with normal leukocyte counts and PaO2 levels in the same range. One minute after drawing the samples, the PaO2 values at 2 degrees C were significantly higher than those stored at 22 degrees C. Later, there was a rapid and progressive decline in PaO2 values in both samples stored at 2 degrees and 22 degrees C. Rapid consumption of O2 by leukocytes is liable to result in erroneous diagnosis of severe hypoxemia in patients with extreme leukocytosis. Immediate cooling of the samples is insufficient to eliminate this process.

Blood Gas Analysis↗
PubMed1988

Growth and ethnicity in scoliosis.

We analyzed height, weight, and body-mass index of 54,030 male and 38,102 female army recruits who underwent a complete routine health assessment at the age of 17 years. Totally, 6,711 males and 4,864 females were diagnosed as having idiopathic scoliosis and were categorized according to 3 grades of severity. There was a difference in prevalence in both sexes with parental origin from Iraq and western Europe. Females as compared with the males were at increased risk of developing the more severe grades of scoliosis. Young scoliotic adults were taller, lighter, and thinner than the nonscoliotic controls. These differences in height, weight, and body-mass index correlated with the severity of the scoliosis. We suggest that genetic factors and growth pattern are of major importance for the prevalence of scoliosis.

Adolescent↗
PubMed1988

Hydrocortisone resolves persistent neonatal jaundice in multiple hormone deficiencies.

Association of prolonged neonatal cholestasis with hypoglycemia, small penis and congenital hypothalamo-hypopituitary derangement is presented. The infant's jaundice was unresponsive to thyroxine replacement therapy but resolved rapidly with hydrocortisone therapy. The time relationships between persistent jaundice and thyroxine and cortisol deficiencies are discussed.

Adrenocorticotropic Hormone↗
PubMed1988

IgA antigliadin antibodies in childhood celiac disease.

Serum IgA-antigliadin antibodies (SAGA) were measured by ELISA in 46 children with proven celiac disease (CD), in 52 children with probable CD, and in 85 control subjects. Small intestinal biopsy was done within 3 months of the SAGA determination in all children. In the proven and probable CD groups, SAGA values were greater than 70 mu/ml in 76 of 82 biopsies that showed severe mucosal damage, but in only 4 of 31 with normal mucosa; thus specificity was 87.1% and sensitivity 92.7%. In the control group, only 12 of 85 children with normal biopsies had a similarly raised SAGA value. SAGA levels decreased significantly when a gluten-free diet was instituted, and rose to abnormal levels in most children on gluten challenge. IgA-SAGA can be used for monitoring dietary compliance during different phases of CD. Although it may help in selecting some children who are evaluated for the possibility of CD, for small intestinal biopsy, children with active CD may show negative SAGA values. The test should therefore not be used as the sole or final determining factor for the performance of small intestinal biopsy. In the proper clinical setting, a biopsy should be done, regardless of the SAGA results.

Adolescent↗
PubMed1987

[Lactic acidosis].

Explore the source record for details and available documents.

Acidosis, Lactic↗
PubMed1987

Convulsions in childhood shigellosis. Clinical and laboratory features in 153 children.

We studied 153 children who experienced convulsions associated with shigellosis. The male-female ratio was 1.2:1.0. Thirty-six children had a previous history of febrile convulsions, and 31 children had a family history of convulsive disorder. Most of the children were 0.5 to 3 years of age, although 49 (32%) were older than 3 years of age and 20 (13.1%) were older than 5 years of age. All children were febrile; in 75% of the children, the temperature was over 39 degrees C. The majority of the children had generalized, self-limited convulsions, which lasted less than ten minutes. In 30 children the seizures were categorized as complex; ten of them had recurrent episodes, although none had any residual neurologic deficit. The total leukocyte count was usually within normal limits, but the differential count characteristically showed a marked increase in the number of band forms. Hypocalcemia (blood calcium level, less than 9.01 mg/dL [less than 2.25 mmol/L]) was observed in four patients; hyponatremia (blood sodium level, 130 mEq/L [130 mmol/L]), in 11 patients; and hypernatremia (blood sodium level, 157 mEq/L [157 mmol/L]), in one patient. Electroencephalographic (EEG) studies were performed in ten children, and lumbar punctures were performed in 34 children; both procedures usually yielded normal results. Shigella sonnei was isolated from 69% of the children; Shigella flexneri from 25%; Shigella boydii from 5%; and Shigella dysenteriae from 1%. Due to the benign and self-limited nature of most of the convulsions, neither diagnostic procedures, nor drug therapy, are usually necessary. These measures should, however, be considered in complicated cases characterized by focal or prolonged seizures.

Blood Glucose↗
PubMed1987

Syndrome of osteopetrosis and muscular degeneration associated with cerebro-oculo-facio-skeletal changes.

We describe an infant with cerebro-oculo-facio-skeletal manifestations, radiologic and pathologic findings of osteopetrosis, and severe myopathic degeneration proven on histopathologic study of muscles. The muscle changes appear to be part of the pathogenetic process in this syndrome and the cause of the flexion contractures present at birth. Real-time ultrasonography may prove a useful tool in prenatal diagnosis of this syndrome.

Arthrogryposis↗
PubMed1987

The effect of lumbar puncture procedure on blood glucose level and leukocyte count in infants.

Blood glucose level, urea concentration, and total white blood cell count were determined both before and 10-15 minutes after lumbar puncture (LP) procedure in 26 infants suspected of having meningitis. There was a significant (p less than 0.001) increase in the peripheral white blood cell (WBC) count (mean +/- standard deviation) from 10,960 +/- 3,500 cells/microliter before to 13,300 +/- 3,970 cells/microliter following the LP procedure, due to relative rise in the neutrophils and lymphocytes. Blood glucose levels did not change significantly following this procedure (85.3 +/- 13.4 mg/dl and 84.1 +/- 12.6 mg/dl respectively). An LP procedure does not impair correct cerebrospinal fluid glucose/blood glucose determination but may cause elevation of peripheral WBC count.

Blood Glucose↗
PubMed1987

Presternal swelling in mumps.

A case of presternal swelling associated with mumps is presented. presternal swelling occurs secondary to obstruction of the lymphatic drainage from the anterior-superior chest wall by the enlarged cervical salivary glands. The occurrence of this complication in mumps is discussed.

Child↗