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Biomedical subjects

M Nitzan

Publications and source records attributed to M Nitzan.

At least 91 records · Page 5Linked to original sources
PubMed1986

Short stature as the major manifestation of celiac disease in older children.

Celiac disease was diagnosed by jejunal biopsy and response to gluten elimination in 11 of 23 children with short stature referred after negative endocrine evaluation. The mean age of the group was 11 years, with a range of 5-16. All had been followed for a mean of 2.5 years at a large pediatric endocrine clinic for the evaluation of growth retardation. Bone age retardation of more than 25 percent of the chronologic age was found in all children. Microcytic anemia and past history of gastrointestinal problems were typical of the celiac group but were not documented in the nonceliac patients. Stool fat excretion was a specific but insensitive test, while the 1-hour blood xylose test was of no value in differentiating between the two groups. Close cooperation between pediatric endocrinology and gastroenterology clinics may be fruitful in the identification of celiac patients, especially in a group of older children with short stature, bone age retardation, and microcytic anemia.

Adolescent↗
PubMed1986

Adenovirus type 3 infection with systemic manifestation in apparently normal children.

Between July 1983 and February 1984, eight children with adenovirus Type 3 infection, proven by virus isolation from sputum, stool or nasopharyngeal swabs and a fourfold increase in complement fixation antibody titers against the virus, were treated in our department. All eight patients had fever lasting at least 7 days, hepatomegaly, diffuse pulmonary infiltrates and abnormal liver function tests. Seven of the patients exhibited dyspnea and pulmonary wheezing. Six of the patients developed changes in state of consciousness, and three had repeated convulsions. EEG patterns in three of the patients were compatible with encephalopathy. Other clinical manifestations included: follicular tonsillitis in two patients, diarrhea in two, pneumothorax in one, and shock with disseminated intravascular coagulation in one. The spectrum of adenovirus Type 3 infection reported here has been described previously only in the viral hemorrhagic fevers. This adenovirus Type 3 infection shares the potential for disseminated disease that has been described previously for Type 7, simulating Reye's syndrome.

Adenoviridae Infections↗
PubMed1985

X-linked lymphoproliferative syndrome. A new kindred with variable phenotypic expression.

A kindred with five affected maternally related male members showed variable phenotypic expression of the X-linked lymphoproliferative syndrome. In one of the children, agammaglobulinemia developed following infectious mononucleosis. His brother had aplastic anemia in infancy and 21/2 years later died of overwhelming pneumonia resulting from ornithosis. A third brother died of reticulum cell sarcoma. Two maternally related male cousins died of reticulum cell sarcoma of the neck.

Adolescent↗
PubMed1985

Naloxone is protective against indomethacin-induced intestinal ulceration in the rat.

Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats. We studied its possible protective effect against indomethacin-induced intestinal ulceration in the rat. Naloxone was indeed found to possess a marked protective effect on the intestinal mucosa (ulcer index 73.3 +/- 13.6 vs. 273.8 +/- 21.8, p less than 0.001). Naloxone was found to elevate basal intestinal mucosal prostaglandin E2 (p less than 0.001) and cyclic adenosine monophosphate levels (p less than 0.005) but was unable to overcome the inhibition of prostaglandin E2 caused by indomethacin. An increase of cyclic adenosine monophosphate levels was seen, however, even in the presence of indomethacin, suggesting that cyclic adenosine monophosphate, but not prostaglandins, may play a role in the protective effect of naloxone.

Animals↗
PubMed1985

Transient heat clearance method for regional blood flow measurements.

A method for assessing regional blood flow by transient heat clearance is described. A probe at room temperature is attached to the tissue which is to be investigated and the temperature of the probe is thereby decreased. The time constants which describe the increases in tissue temperature as the temperature approaches equilibrium temperature are related to blood flow. Regional blood flow can be determined by the method of transient heat clearance without calibration.

Body Temperature Regulation↗
PubMed1985

Hypernatremic dehydration and hypothermia in congenital lamellar ichthyosis.

Several events of hypernatremic dehydration occurred in five infants suffering from severe congenital lamellar ichthyosis. Simultaneously, four of them developed hypothermia. Both phenomena were probably caused by excessive water loss through the affected skin. In lamellar ichthyosis the skin loses its function as an effective barrier and therefore its role in water and temperature homeostasis is defective.

Dehydration↗
PubMed1985

Protein conservation by the immature intestine.

Uptake of intact macromolecules by the immature gut is a well-known phenomenon, but no information exists on the possibility that there is also increased protein loss in the intestinal lumen in preterm infants. We determined alpha-1-antitrypsin (A-1-AT) levels in fecal samples from 39 infants born after 27-41 weeks of gestation from birth up to 30 days of age. A-1-AT levels were elevated only in meconial stools, and low in nonmeconial stools, regardless of associated respiratory disorders, drug administration, and type of nutrition. This study shows that the immature gut has a mature pattern of protein conservation at least as early as after 29 weeks of gestation.

Feces↗