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Biomedical subjects

M Moser

Publications and source records attributed to M Moser.

At least 397 records · Page 22Linked to original sources
PubMed1980

[The effect of experimentally induced histamine deficiency on growth and rate of taking of model tumours (author's transl)].

From oncolytically effective clostridial strains, the intact washed or fractionated material of the spores and vegetative forms and culture media were examined for histamine decomposing activity in previous in vitro experiments (14). In a fractionated state, all strains cause a reduction of histamine activity. Therefore histaminases are present as endozymes. When the spores germinate to vegetative forms on the tumour following i.v. injection, the cell wall breaks open and the enzymes are released. Möse et al. (13) described rapid and nearly complete decomposition of plasmakinins (specifically bradykinin) by means of the above mentioned special preparations of clostridial strains with oncolytical effect (culture media partially excepted). Bradykinin and histamine are vasoactive substances, which are significant in terms of fine regulation of the capillary circulation. Continuous inactivation of these tissue hormones effected by the (clostridial) vegetative forms concentrated in the tumour may decrease the capillary circulation and thereby favour necrotization or decomposition of the tumour. In this animal experiment the effect of this biogenic amine on growth and rate of taking of tumours by means of artificially produced changes in the flowing equilibrium of the histamine metabolism was to be shown. Mice: While feeding mice a pyridoxal phosphate-free diet, a Harding-Passey melanoma was inoculated: The tumour weights were slightly lower in the case of animals put on the diet than in controls. Rats: Histamine-free diet and treatment with semicarbazide (in the course of the treatment implanzation of a Walker tumour). The taking of the tumours was significantly delayed or their growth reduced as a result of the diet or the treatment with semicarbazide or both.

Animals↗
PubMed1979

[Reduced blood supply of the vestibular centers. Clinical and experimental studies].

To explain the origin of the narrow nystagmus writing (petite écriture) selected patients with hypoxemia were examinated using the pendular rotating test and ENG. Blood gas analysis was used to determine pO2 reduction. The decreased oxygen saturation was corresponding to the decreased amplitude of nystagmus. In a second experiment with alert rabbits the inspired gas mixture was altered to obtain hypoxia (8% O2+ 92% N2, controlled with blood gas analysis). A significant reduction from the normal nystagmus reaction was observed. This reduction in the amplitude (about 50%) is immediately reversible by giving oxygen. These experiments were repeated with each animal several times, the results being reproductible. There is a significant decrease in amplitude of nystagmus through the influence of hypoxia.

Animals↗
PubMed1979

[Central nystagmus writing during the pendular test. Findings on post-punctural symptoms after lumbar puncture (author's transl)].

The central nystagmus writing (ecriture centrale) during the pendular test is characteristically found in cerebral organic or functional lesions. Thirty patients with symptoms following lumbar puncture (L.P.) were investigated with the pendular test. In 46.6% central nystagmus writing was found 3 days after L.P. After subsiding of post L.P. troubles all the nystagmograms became normal. A control group of 30 patients without symptoms after L.P. did not show patholgic variations in the nystagmus writing during the pendular test.

Adult↗
PubMed1979

Propranolol and newer antihypertensive drugs in the management of hypertension.

Among the newer antihypertensive agents are the beta-blocking drugs, such as propranolol. These agents are useful as second-step drugs to be used if diuretic therapy alone is not effective. In mild to moderately severe hypertension, propranolol, in does of up to 480 mg/day in combination with a thiazide diuretic, has been found to be effective in over 80% of patients on long-term therapy. This degree of response is essentially similar to that noted with a combination of reserpine and a diuretic agent. Although some observers believe that propranolol produces many fewer side effects than the other step 2 drugs (reserpine and alpha-methyldopa), there are some patients who do experience restlessness, insomnia, and depression. Clonidine may be substituted for another step 2 drug, is of moderate potency, but may not be tolerated by a large number of patients because of the severe dry mouth and drowsiness that it produces. Prazosin appears to be a suitable substitute for hydralazine as an effective vasodialator if thiazides plus propranolol or thiazides plus reserpine or alpha-methyldopa are not effective. In some instances, it many be an acceptable second-step drug because of its alpha-adrenoreceptor-blocking properties. The angiotensin II competitive inhibitors or converting enzyme inhibitors may in the future have some place in the management of hypertension.

Angiotensin II↗
PubMed1979

[Multichannel monopolar ERA (author's transl)].

Six channel monopolar recordings are superior to single channel bipolar recordings when considering equal phased potentials, partially missed or only partially occurring potentials. It is hoped that additional information concerning defects of speech or behaviour in disorders of communication and coordination can be gained by mapping topographically excitation of the neural population.

Acoustic Stimulation↗
PubMed1979

[Automated body plethysmography of respiration and voice efficiency (author's transl)].

Efficiency of voice (EV) is understood as the ratio of gained acoustic power to respiratory power during phonation. A fully automatic computer programmed to calculate the EV and the subglottic pressures via body plethysmography is described. The EV ranges from 0.5 x 10(-5) to 120 x 10(-5). The relationship between EV and sound pressure is demonstrated. The results were reproducable.

Automation↗
PubMed1979

[Computer analysis of electronystagmograms. First report: the normal pendular test ENG (author's transl)].

In an attempt to standardize the interpretation of electronystagmograms the results of computerized analysis of pendular test nystagmograms have been statistically evaluated. All the nystagmus components show marked dependance on age. The range of normal reactions is determined by means of double standard deviation. The cumulogram of the nystagmus slow phase demonstrates the smallest deviation of all the analysed parameters, and this makes it suitable in the pendular test for diagnostic estimation. The cumulogram provides information on nystagmus slow phase duration, amplitude, symmetry or irregularity.

Computers↗
PubMed1978

[Narrow nystagmus writing and hypoxemia of the central vestibular system (author's transl)].

To explain the origin of the narrow nystagmus writing (petite écriture), selected patients with hypoxemia were examined using the pendular rotating test and ENG. Bloodgas analysis was used to determine pO2 reduction. The decreased oxygen saturation was corresponding to the decreased amplitude of nystagmus. In a second experiment with alert rabbits the inspired gas mixture was altered to obtain hypoxia (8% O2 + 92% N2, controlled with bloodgas analysis). A significant reduction from the normal nystagmus reaction was observed. This reduction in the amplitude (about 50%) is immediately reversible by giving oxygen. These experiments were repeated with each animal several times, the results being reproductible. There is a significant decrease in nystagmusamplitude through the influence of hypoxia.

Animals↗
PubMed1978

[Pendular test and ENG in rabbits (author's transl)].

25 rabbits are investigated by the pendular test. By an angular acceleration of 90 degrees/s2 the averaged values of the nystagmic parameters are: the amplitude 12 mm, the frequency 8 beats in a half periode, the angle velocity of the slow component 50--60 mm/s and the threshold for the pendular test 2--5 degrees/s2 and the rotationstest 1 degree/s2. There is no vestibular habituation and no fatigue. Always the nystagmic reaction is clear and reproducible.

Animals↗
PubMed1978

Prognosis of adequately treated hypertensive patients.

Adequate antihypertensive therapy will lower blood pressure to normotensive or near normotensive levels in 80-85% of patients. Long-term treatment results in a marked decrease in strokes and stroke recurrence, heart failure, renal failure, and progression to accelerated hypertension. The effects of long-term therapy on the occurrence of coronary artery disease are unclear.

Blood Pressure↗
PubMed1978

[Experimental investigations of vestibulary hypoxia (author's transl)].

In an experiment with alert rabbits the inspired gas mixture was altered to obtain hypoxia. A significant reduction from the normal nystagmus reaction was observed. This reduction in the amplitude (about 50%) is immediately reversible by giving oxygen. These experiments were repeated with each animal several times, the results being reproductible. There is a significant decrease in nystagmus amplitude through the influence of hypoxia.

Animals↗