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Biomedical subjects

M Kunze

Publications and source records attributed to M Kunze.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Protein studies in cystic and peritoneal fluids of ovarian tumors with special reference to CEA].

The levels of total protein, Ig, AFP, beta-HCG, CEA, SC, SP1 and alpha 2-PAG were measured in cystic and peritoneal effusions obtained from 70 females with benign and malignant ovarian tumors. This study was carried out to test out parameters those are useful for tumor monitoring of ovarian cancer. Our results indicate that determining CEA in peritoneal effusions could be one of useful methods in tumor monitoring of mucinous cystadenocarcinomas in cases of known histology and praetherapeutic estimated CEA levels in cystic or peritoneal effusions. Our results demonstrate that CEA-levels greater than 100 micrograms/l are mostly found in mucinous cystadenocarcinomas and in mucinous cystadenomas, too. High cystic CEA levels support the histology aiming for demonstration of mucinous component.

Adolescent↗
PubMed1987

[Epidemiology of hypercholesterolemia in the Vienna area].

Hypercholesterolaemia is the most important risk factor in coronary heart disease (CHD). Epidemiological data are not available for the region of Vienna and the aim of this investigation was to obtain them. The municipal health investigation centres are attended by 6000 to 8000 people from the region of Vienna each year, who may voluntarily use these services once a year without any cost. We analysed total cholesterol, HDL cholesterol and the ratio of total to HDL cholesterol of 733 unselected men and women aged 20 to 79 years, who visited one of the centres in May 1986. The classification was carried out according to the recommendations of the National Institutes of Health (Bethesda, USA, 1984). Using these guidelines 26.0% of the men and 26.6% of the women have normal total cholesterol levels. With regard to total cholesterol 55.0% men and 44.3% women have elevated levels and 19.0% of men and 29.2% of women are at high risk of developing CHD. The mean ratios of total to HDL cholesterol, which is closely related to CHD risk, and the proportion with a value above 4.5, which is associated with elevated CHD risk, are closely related to Austrian trends in ischaemic heart disease, which are unfavourable, especially in middle aged men, the so-called "young myocardial infarctions".

Adult↗
PubMed1987

[Pregnancy protein-1 in the serum of patients with diseases of the breast].

Pregnancy-specific beta 1-glycoprotein (SP1) was assayed by enzyme immunoassay in serum from 32 patients with breast diseases (11 mastopathies, 6 benign tumors and 15 breast cancers). Healthy blood donors were used as control group. There were significant differences between the SP1-serum concentrations of patient group (mastopathies, benign tumors, breast cancer) and the control group (p less than 0.001). The SP1-values of the groups with mastopathies, benign tumors and breast cancer did not differ significantly. Elevated SP1-concentrations were found in 4 of 11 patients with mastopathy, in 3 of 6 patients with benign tumor and in 10 of 15 patients with breast cancer versus 1 of 24 blood donors. With the help of SP1 determination in serum of 5 breast cancer patients before operation and 6 months post operation we did not found a correlation with further clinical course.

Adenocarcinoma, Scirrhous↗
PubMed1987

[Clinical value of CEA studies in patients with benign and malignant breast diseases with special reference to oncologic after care].

Carcinoembryonic antigen (CEA) was assayed by radio immunoassay in serum of 87 patients with breast cancer and 85 patients with benign breast tumors from 1983 to 1986. The sensitivity of 43%, the specificity of 89%, the predictive values in regard to a positive assay result of 75% and in regard to a negative assay result of 67% was determined in consideration of a changed prevalence. It is referred to the importance of the estimation of CEA in the individual diagnosis, monitoring and follow up of patients with breast cancer. It is claimed the follow up for the premature recording of a recurrency the aid of CEA-estimation in always the same technical variant at the same patient.

Breast Neoplasms↗
PubMed1987

[Behavior of some tumor markers (secretory immunoglobulin A, pregnancy-associated alpha 2-glycoprotein, circulating immune complexes in the serum of patients with breast tumors].

Concentrations of secretory immunoglobulin A (S-IgA), pregnancy associated alpha 2-glycoprotein (alpha 2-PAG) and circulating immune complexes (CIC) were estimated in serum samples of 20 blood donors, 14 patients with benign mamma tumors, 44 patients with mastopathies and 33 patients with breast cancer disease. The proteins were determined by means of the single radial immunodiffusion and the polyethylene glycol precipitation. S-IgA serum concentrations of the cancer group compared with those of the benign tumors, were increased significantly (benign tumors: mean = 40.27 mg/l; s = 15.61; carcinoma disease: mean = 78.87 mg/l; s = 72.80). alpha 2-PAG serum concentrations of the cancer-and benign tumor group as well as the mastopathy group were also increased significantly in comparison with the blood donor group (blood donors: mean = 143.75 mg/l; s = 198.50; benign tumors: mean = 295.85 mg/l; s = 232.64; mastopathies: mean = 190.86 mg/l; s = 177.77; carcinoma disease: mean = 192.52 mg/l; s = 172.88).

Adolescent↗
PubMed1986

[Current status and the development of resistance of important urinary pathogens to antibiotics in the Suhl district 1970-1984].

In a retrospective study over a period from 1970 to 1984 the distribution of frequency and the behaviour of the resistance of urine germs out of more than 43,000 sendings from outpatient and hospital institutions of the county of Suhl were analysed. In the period of observation the proportion of isolated E. coli redoubled and was nearly 68% in 1984. Conspicuous were a decrease of the isolates of Str. faecalis from 32 to 4% and an increase of problem germs of the Klebsiella group to 9.7%. The resistance situation is characterized by a distinct decrease of the resistance of E. coli in comparison to antimicrobial substances with smaller consumption (sulphonamides, chloramphenicol, nitrafurantoin) without homogeneous behaviour of the problem germs.

Anti-Bacterial Agents↗
PubMed1986

[Acute bacterial meningitis in adults--a therapeutic problem].

Even with reference to the available modern chemotherapeutics the acute bacterial meningitis represents a therapeutic problem. References to indication and dosage of several chemotherapeutics are given on the basis of recent knowledge of liquor metabolism as well as clinical and experimental findings. The used doses in medical practice are mostly situated below the necessary doses and could be the cause for a non-sufficient reaction among other things.

Adult↗
PubMed1986

[Current resistance in surgical infections and its development since 1970].

More than 7,000 bacteriological samples were received by the authors and were analysed for the frequency of resistance among pyogenic cocci which are relevant to surgical practice. Staphylococcus aureus accounted for 41 per cent and Escherichia coli for 15.3 per cent. These were the most common germs in 1984. Resistance of Staphylococcus aureus to ampicillin was as high as 78 per cent. Resistance levels below eight per cent were recorded in the context of lincomycin, erythromycin, gentamicin, oxacillin, and berlocombin. Resistance ratios of Escherichia coli were 55.2 per cent to ampicillin, 4.5 per cent to gentamicin, and 12.6 per cent to berlocombin.

Abscess↗
PubMed1986

Smoking control implementation. Educational programmes and information in developed countries.

Smoking control should be achieved by implementing comprehensive programmes including public information, health education, cessation 'treatment', and legislation. Health education for children will have only modest impact as long as smoking is still a symbol of being grown-up, of social status and prestige. Separate programmes should be designed for public information, school health education and hospitals and health professionals. Health education and public information are the prerequisites for comprehensive smoking control programmes because they create and maintain problem awareness. On the other hand, a ban on advertising for tobacco is a prerequisite for successful health education. The ultimate goal of health education and information is promotion of the positive social image of nonsmoking behaviour.

Health Education↗
PubMed1985

[Experimental study of pathological and normal early pregnancy with the E rosette test].

The E rosette test was made at 35 women with disturbances in early pregnancy (gestational weeks 8 to 12). 61 women with normal pregnancy and 33 nonpregnant women were taken as control persons. There were no significant differences between procentual and absolute numbers of E rosettes of women with deranged pregnancy, of women with normal pregnancy and nonpregnant women. We did not learn to differentiate between Abortus imminens (with intact pregnancy) and real occurred fetal death by the E rosette test. Pregnant women had higher leucocyte values and procentual lymphocyte rates than nonpregnant women.

Abortion, Incomplete↗
PubMed1985

[Appendicitis and pregnancy].

In the years of 1981 to 1983 15 pregnant patients had to be operated on because of suspected appendicitis. In 10 patients acute symptoms of inflammation of the appendix could be proved histologically. Morbidity rate was 2.1 per thousand related to a over-all of 4766 births in the 3 years.

Abortion, Spontaneous↗