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Biomedical subjects

M Kitagawa

Publications and source records attributed to M Kitagawa.

At least 523 records · Page 29Linked to original sources
PubMed1985

[Acute myeloid leukemia with intracranial tumor formation--case report].

A 44-year-old house-wife was admitted to the hematological clinic of our hospital on December 21, 1981 for the treatment of acute myeloid leukemia. Hematological examination showed severe anemia, leukocytosis and thrombocytopenia. She was soon started on DCMP therapy (Daunomycin, Cytosine arabinoside, 6-MP and prednisolone). After several repeats of remission and aggravation, she suffered from vertigo, nausea and vomiting in early August of 1982. The CT scan and angiography showed a mass lesion in the middle of the posterior cranial fossa. On August 26, surgical extirpation of the tumor locating in the vermis of the cerebellum was performed successfully. On gross examination the tumor revealed smooth yellowish-red surface, elastic in consistency and measured 40 X 40 X 30 mm in size. Histologically it comprised the leukemic cells. The pathology of the central nervous system due to leukemic cells was discussed in relation to the pertinent literature, including the CT findings and the indication of the surgical treatment.

Adult↗
PubMed1985

[Pharmacokinetics of ceftizoxime suppository in experimental animals].

Ceftizoxime suppository (CZX-S) was administered rectally to mice, rats and dogs, and the pharmacokinetics were studied in comparison with those after intravenous, intramuscular and subcutaneous administration of ceftizoxime (CZX). Absorption of CZX given rectally was rapid in all animals, similar to intramuscular or subcutaneous administration. The peak serum levels of CZX in mice, rats and dogs when administered rectally at a dose of 25 mg/kg were 23.1 micrograms/ml at 7.5 minutes, 23.5 micrograms/ml at 15 minutes and 25.2 micrograms/ml at 15 minutes, respectively. These values were about 76%, 68% and 42% of the values for subcutaneous or intramuscular administration in mice, rats and dogs at the same respective doses. Urinary recoveries of CZX after rectal administration of 25 mg/kg were 44.2% (0-12 12 hours) in rats and 27.7% (0-6 hours) in dogs, and 2.7% (0-6 hours) of the dose was excreted into bile fluid in rats. Organ distribution of CZX when administered rectally to rats was similar in distribution pattern to that of muscular administration, although its concentrations in various organs were slightly lower than those for intramuscular administration, as was the case for serum concentration. Serum concentrations of CZX were proportionately elevated with dose when dogs were rectally administered CZX-S in doses of 12.5, 25 and 50 mg/kg. In the case of multiple administrations (t.i.d. for 10 days) of CZX-S to dogs, no remarkable difference was found in serum concentrations of CZX in comparison with single doses, and no accumulation of CZX was demonstrated.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1985

Lymphoid interstitial pneumonia: findings at bronchoalveolar lavage.

In a patient with lymphoid interstitial pneumonia (LIP), confirmed by open lung biopsy, immunological derangement was evaluated using bronchoalveolar lavage fluid and peripheral blood. In the bronchoalveolar lavage fluid there were 20% null cells, 0% B cells, 77% alveolar macrophages and 3% T cells; in the peripheral blood these were 12% null cells, 43% B cells, 26% mononuclear phagocyte system cells, 2% double marker cells and 17% T cells. Thus there was T cell depletion and null cell increment in bronchoalveolar lavage, in contrast to T cell depletion and increment of B cells and mononuclear phagocyte system cells in the peripheral blood.

Adult↗
PubMed1985

[A case of complete regression of gastric carcinoma and liver metastases by treatment with tegafur].

The patient was a 70-year-old man who had complained of epigastric discomfort since March 1980. In April his liver was found to be enlarged on examination by his family doctor, and he was referred to our hospital. By X-ray and endoscopic examination a carcinoma of Borrmann type 2 was found in the lesser curvature of the body of the stomach. Biopsy of the tumor disclosed papillotubular adenocarcinoma. multiple liver metastases were demonstrated by computed tomography. From May 1980 tegafur (FT-207, 750 mg) in the from of a suppository was given daily. During the course of endoscopic follow-up the shape of the gastric carcinoma changed to one of an irregular shallow ulceration and biopsy failed to reveal cancer cells in August 1980. In April 1981 only an ulcer scar remained in the stomach. In February 1981 computed tomography showed small low-density areas in the liver, but these had completely disappeared by June 1982. Starting in August 1980, tegafur suppository was given on alternate days until June 1984. By this time there had been no recurrence of the carcinoma either in the liver or in the stomach, and the chemotherapy was discontinued. By the WHO standard for cancer chemotherapy this patient therefore corresponds to the class of complete response.

Adenocarcinoma↗
PubMed1985

[Studies of urinary risk factors in urolithiasis].

Urinary excretions of calcium, oxalate and uric acid were estimated in 160 stone-formers (male 118, female 42) and 257 healthy controls (male 207, female 50). Stone-formers were divided into two groups according to their stone analysis: calcium containing stone-formers and non-calcium stone-formers. Calcium stone-formers were divided again into those who had a single stone episode and multiple or recurrent stone episodes. Urinary calcium and oxalate showed significant increases in calcium stone-formers, while urinary uric acid increased only in male calcium stone-formers. Recurrent calcium stone-formers demonstrated significant high levels of urinary calcium excretion especially in males, whereas no difference of urinary oxalate excretion between recurrent and single stone-formers. The frequency distributions on the excretion of three subjects were estimated respectively in patients with calcium stone and in controls. Relative risks, risk curves and stone probabilities were proposed and compared. The higher excretion values of urinary calcium and oxalate closely related to higher risks of forming calcium stones. On the other hand, urinary uric acid did not have such a relation to calcium stone formation. We defined the states which urinary excretions exceeded 95% upper confidence limits of normal controls as hyperexcretions. Hypercalciuria was more than 200 mg/day in male and female, hyperoxaluria was 50 mg/day in male and 45 mg/day in female and hyperuricosuria was 850 mg/day in male and 650 mg/day in female according to our definition. Among male calcium stone-formers, hypercalciuria was found in 45.3%, hyperoxaluria in 26.4% and hyperuricosuria in 15.1%. While in female calcium stone-formers, hypercalciuria in 23.7%, hyperoxaluria in 26.3% and hyperuricosuria in 13.2%. Of the male calcium stone-formers 57.5% showed either or both hypercalciuria and hyperoxaluria, and recurrent stone-formers also demonstrated a higher incidence among them. Excretion products of urinary calcium and oxalate were calculated and compared in each group. Calcium stone-formers showed significant high values especially in male recurrent stone-formers. The estimation by combining some risk factors will provide more useful means of assessing severity of urinary calculous diseases and therapeutic effects of their various treatments.

Calcium↗
PubMed1985

[A case of retroperitoneal neurinoma].

Retroperitoneal neurinoma is a rare disease, although retroperitoneal tumor is rather common. A 40-year-old man without any clinical symptoms was admitted to our hospital for a medical examination. Ultrasonogram demonstrated a cystic mass over the right kidney. This cystic mass was suggested to be a right adrenal tumor by CT scan and angiogram. All of the laboratory data including endocrinological data were within the normal limits. Under the diagnosis of right non-functioning adrenal tumor, an operation was performed through a right lumbal incision. A round and tennis ball sized tumor with a fibrous capsule was identified and freed from the right kidney and the right adrenal gland, and the tumor was extirpated uneventfully. The surgical specimen was 9.5 X 8.0 X 6.5 cm in size, 260 g in weight, and the histological diagnosis was neurinoma (Antoni-B type).

Adult↗
PubMed1985

[Recurrence following operative treatment of renal staghorn calculi and prophylaxis].

Residual stone and stone recurrence following operation for renal staghorn calculus were investigated in 58 kidneys of 55 patients. Residual stones were found in 12 kidneys (20.7%), but cases who underwent intraoperative radiogram using Kodak X-O mat KS film or extracorporeal renal surgery showed no residual stones. True recurrence was observed in 9 kidneys (19.6%). The rates of true recurrence after partial nephrectomy, nephrolithotomy, extended pyelolithotomy and autotransplantation with extracorporeal renal surgery were 29.2%, 8.3%, 33.3% and 0% respectively. Morphological study of renal tissue removed intraoperatively from patients with staghorn calculus suggested that calcium deposits in pelvic mucosa or collecting tube might play an important role in stone recurrence. However, despite the calcium deposits in removed specimens, no recurrences have been observed in patients who underwent extracorporeal surgery for complicated staghorn calculus. Therefore, this procedure might be useful to prevent stone recurrence.

Female↗
PubMed1984

The gene coding for lipoprotein signal peptidase (lspA) and that for isoleucyl-tRNA synthetase (ileS) constitute a cotranscriptional unit in Escherichia coli.

The lspA gene coding for lipoprotein signal peptidase is located very close to the ileS gene coding for isoleucyl-tRNA synthetase on the Escherichia coli chromosome. Deletions were generated in vitro from both ends of the 4.3 kb fragment that carries the lspA gene and the ileS gene, and the expression of the two genes was examined before and after insertion of the trp promoter-operator at one end. The results indicate that the lspA and ileS genes constitute a cotranscriptional unit in the order of promoter- ileS - lspA . The gene order of dnaJ - rpsT - ileS - lspA - dapB around 0.5 min on the E. coli chromosome map was also determined.

Amino Acyl-tRNA Synthetases↗
PubMed1984

Rice bran treatment for patients with hypercalciuric stones: experimental and clinical studies.

The purpose of this study is to confirm the hypocalciuric effect of rice bran experimentally and clinically. Urinary calcium excretion and its absorption in the intestine were reduced significantly by rice bran or phytin in rats fed high calcium diets, while there were no significant decreases with a low calcium diet. For the clinical study 70 patients with idiopathic hypercalciuria were treated with rice bran (10 gm. twice daily) for 1 month to 3 years. In almost all patients rice bran caused a significant decrease in urinary calcium excretion, which was maintained during treatment. Evidence of stones has decreased clearly among patients treated with rice bran for 1 to 3 years, although this might be a halfway judgment of the long-term treatment. We suggest that phytin should be the most effective substance to reduce the intestinal absorption of calcium and that rice bran treatment should be effective for prevention of recurrent urinary stone disease.

Animals↗
PubMed1984

[Renal autotransplantation for ureteral lesions--the indication and the results of operation].

Renal autotransplantation has been a treatment of choice for renovascular hypertension, renal artery aneurysm, complicated staghorn calculi, ureteral disorders and others. The paper reports 5 cases of extensively damaged ureter and discusses the indication and the results of operation. There were three cases of postoperative extensive ureteral stricture. One patient had postoperative ureteral injury with retroperitoneal abscess. The last one showed renal foreign body calculi with recurrent pyelonephritis after ureterocutaneostomy. The postoperative course of four patients had been uneventful revealing well functioning autotransplanted kidneys without hydronephrosis and infection during the follow-up period of 22 to 42 months. However, the patient with the ureteral injury and retroperitoneal abscess died of bleeding from renal vein anastomosis on the 15th postoperative day, since the renal pedicle showed marked inflammatory change including renal vein wall. Subsequently, autotransplantation is contraindicated in the cases with marked inflammation in the renal pedicle. In cases of various other ureteral lesions including long distance ureteral stricture, this procedure is recommended when neither the end to side ureteral anastomosis, Boari's bladder flap operation nor bladder hitch operation is feasible.

Adolescent↗
PubMed1984

[Clinical statistics on inpatients and operations in the Urological Department of the Wakayama Red Cross Hospital (April, 1979 to March, 1983)].

Statistical observations made on the 1,102 inpatients and 1,127 operations at our clinic between April 1979 and March 1983 were reviewed. The patients were most frequently in their sixties, and lately patients under 10 are increasing. The most frequent diseases of the inpatients were benign prostatic hypertrophies, ureteral calculi, undescended testicles and bladder tumors. The frequently performed operations were those for bladder tumors, phimosis and benign prostatic hypertrophies in order of frequency.

Adult↗