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Biomedical subjects

M J Moore

Publications and source records attributed to M J Moore.

At least 181 records · Page 10Linked to original sources
PubMed1977

New evidence on the value of birth expectations.

Past national surveys regarding birth expectations have usually been restricted to currently married women, a fact which has led demographers to question the usefulness of these data. Because the June 1976 Current Population Survey includes the expectations of all women in a cohort regardless of marital status, it provides the data needed to evaluate biases due to restricted survey universes. At older ages, where there are substantial differences in lifetime expectations between currently married and single women, there are relatively few single women; at younger ages, however, where the proportion of single women in a cohort is relatively large, the differences in expectations are small. This counterbalancing effect makes the lifetime birth expectations of currently married women a close approximation of all women in a cohort. The analysis also indicates that the observed intracohort declines in lifetime birth expectations since 1967 were due largely to the addition at subsequent survey dates of previously unmarried women; nevertheless, some "true" cohort declines also seem to have occurred.

Adolescent↗
PubMed1973

Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat.

Experimental allergic encephalomyelitis (EAE) was induced in rats of various genotypes by injection of 10 microg guinea pig basic protein in complete Freund's adjuvant containing 100 microg H(37) RV M. tuberculosis. Histologically verified EAE was present in 20/20 Lewis, 17/17 (Lewis x BN)F(1), 9/9 Lewis backcross, and 21/42 BN backcross rats. Among the BN backcross animals, 25/42 were determined to carry the major histocompatibility type characteristic of the Lewis strain and 21 of these had EAE. Separate groups of Lewis, BN, and (Lewis x BN)F(1) rats were immunized as described and skin tested on day 13 with 10 microg guinea pig basic protein and rat S basic protein. Animals of each genotype had Arthus and delayed skin reactivity to both antigens. These data are compatible with the hypothesis that susceptibility to EAE in rats is controlled by an autosomal dominant gene linked to the major histocompatibility locus. It is proposed that this is an immune response gene, designated Ir-EAE, which controls T cell reactivity directed against a highly encephalitogenic portion of the basic protein molecule.

Animals↗