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Biomedical subjects

M J Moore

Publications and source records attributed to M J Moore.

At least 163 records · Page 9Linked to original sources
PubMed1982

Consulting the computer about acid-base disorders.

A computer program was developed at Beth Israel Hospital in Boston to offer consultation to health care personnel treating patients with electrolyte and acid-base disorders, as the diagnosis of these disorders involves consideration of numerous factors and performance of tedious calculations. In order to obtain the necessary diagnostic information, the computer conducts a dialogue between itself and the person seeking its advice. The program then allows the computer to generate an evaluation note, which lists the diagnostic possibilities, explains the pathophysiology, recommends treatment, and provides references to the medical literature. The entire transaction, from data entry to printing, takes about 4 minutes. The computer program also compensates for entry of inconsistent data and for lack of data. Our experience with the program has revealed that it has favorably influenced patient care in a number of cases and has helped our staff better understand the pathophysiology and treatment of electrolyte and acid-base disorders.

Acid-Base Imbalance↗
PubMed1982

Cognitive profiles in reading disability.

A group of 35 reading disable (RD) boys and 35 matched controls were studied over a two-year period in order to evaluate the validity of traditional hypotheses about the cause of serious reading impairment in preadolescent boys for whom the common disadvantages of economic privation, bilingualism, and emotional instability were absent. The popular hypothesis of perceptual deficit was not supported by the data, although the finding that most RD boys have a short-term memory deficit was affirmed. The most important new finding was that about one-fourth of the RD boys had serious difficulty in maintaining an efficient set to process and/or evaluate information, especially when that information was contained in oral speech.

Child↗
PubMed1981

EAE in rat bone marrow chimeras: analysis of the cellular mechanism of BN resistance.

Unlike Lewis strain, BN rats do not develop EAE when given 10 microgram GPBP + CFA. Their resistance is mediated via the MHC-linked gene Ir-EAE-. The cellular mechanism of BN resistance can be probed using bone marrow chimeras between susceptible LBNF1 strain and BN. F1 leads to BN chimeras can develop EAE when actively sensitized with GPBP + CFA, but are markedly more resistant than F1 leads to F1. By contrast, F1 leads to BN chimeras are highly susceptible to passively transferred EAE from an F1 donor. F1 rats reconstituted with BN bone marrow, i.e., BN leads to F1 chimeras, are completely resistant to EAE induced by active sensitization, but they too are susceptible to passively transferred EAE. We argue that Ir-EAE- blocks the development of T cells reactive to self myelin, and that this occurs at the level of macrophage presentation of antigen to the T cell. Suppressor mechanisms do not appear to play a major role.

Animals↗
PubMed1980

Linkage of severity of experimental allergic encephalomyelitis to the rat major histocompatibility locus.

The incidence of EAE is determined by Ir-EAE, a gene linked to the rat MHC. EAE severity can be assessed by quantitative clinical and pathologic measures. Using these measures, one can say that disease severity in LBNF1 is approximately one-tenth that in Lewis. Analysis of LBNF2, LBC, BNBC, and parental Lewis strain reveals that severity is primarily a function of dose of Lewis MHC alleles. Non-MHC genes have a small but discernable effect.

Animals↗
PubMed1978

Bilateral primary germ cell testicular tumors: report of four cases and review of the literature.

Bilateral primary germ cell tumors of the testicle are rare. The last comprehensive review of the literature (1955) revealed a 1.6% incidence. However, during the past twenty years, cases have been reported more often, raising the questions of increased frequency due to prolonged survival following surgery and/or roentgen therapy for unilateral tumors. A search of the medical journals during the past two decades fails to show any increased frequency of bilaterality (1.56%). All general combinations of cell types may occur and the tumors may appear simultaneously or sequentially. Successive seminomas are seen more often followed in frequency by concurrent seminomas. Although 50% of the second primaries were diagnosed within five years, 3% of the patients developed the second tumor after 20 years, stressing the need for extended follow-up. Factors affecting the diagnosis, management and prognosis of bilateral testicular tumors are discussed. Four additional cases of bilateral germ cell tumors are described.

Adult↗
PubMed1977

Eye contact and face scanning in early infancy.

Visual fixations of 3- to 5-week-old, 7-week-old, and 9- to 11-week-old infants were recorded as they scanned an adult's face which was stationary, moving, or talking. A dramatic increase in face fixations occurred between 5 and 7 weeks for all conditions. Talking produced an intensification of scanning in the eye area in the two older groups.

Aging↗