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Biomedical subjects

M Iida

Publications and source records attributed to M Iida.

At least 595 records · Page 33Linked to original sources
PubMed1982

Neurophysiological studies of n-hexane polyneuropathy in the sandal factory.

Among 93 cases of n-hexane polyneuropathy during a large outbreak in 1968 44 cases were studied by conventional electromyogram and measurement of peripheral nerve conduction velocities, both of which showed remarkable changes, especially in the lower rather than the upper extremities. Over a few years since 1968 most of the cases completely recovered, except for a few with mild sensory impairment, after providing for 100 ppm as the maximal allowable concentration of n-hexane and well equipped ventilation systems in individual houses. During the rescreening in 1981, before which there occurred only 2 patients, 21 cases with mild n-hexane polyneuropathy were clinically and neurophysiologically observed, revealing mostly the same features as in the previous outbreak in 1968. From these data it may be suggested that, in spite of less than 50 ppm of n-hexane concentration in a room, the sandal workers have suffered from neurotoxicity from this organic solvent and the appropriateness of the present regulation on n-hexane has to be reconsidered.

Hexanes↗
PubMed1982

[Clinical findings of cefoxitin in the treatment of obstetric and gynecological infections (author's transl)].

A clinical trial with a special emphasis on anaerobic infections was designed for evaluation of the efficacy, safety, and patient tolerance of cefoxitin. Of the 35 patients who clinically evaluated, 19 had intrareproductive organ infections, 8 had extrareproductive organ infections and 8 had urinary tract infections. Twenty-nine out of the 35 (82.9%) responded satisfactorily to therapy with cefoxitin. The daily dose of cefoxitin for the 35 adult patients (ages ranged from 17 to 62 years) were 1--6 g. There were no adverse systemic reactions, nor was any renal or hematologic toxicity noted. Antibacterial activity tests demonstrated that cefoxitin was active against anaerobic bacteria, especially Bacteroides fragilis. Cefoxitin is thought to be the drug of choice in the treatment of obstetric and gynecologic infections.

Adolescent↗
PubMed1982

A study of the ecology of the house dust mite in dwelling houses.

The habitat of dust mites in dwelling houses in Japan was studied to determine the relation between mites in dust and mite allergy. Dust mites increased in the summer and decreased in the winter. Mite propagation was influenced by the temperature and relative humidity. Mites were found in higher concentrations in dust from concrete houses than that from wooden houses. Carpet dust contained numerous mites and tatami, sofas and bed mattresses were also habitats of mites. Mites existed universally in all samples of dust examined. Sensitization to mite allergen depends mainly on the atopic diathesis of patients and not on the mite count.

Animals↗
PubMed1981

Ophthalmoplegia-plus. Its occurrence with periventricular diffuse low density on computed tomography scan.

Familial cases of progressive external ophthalmoplegia, deafness, generalized weakness, and hypogonadism were studied. A muscle biopsy specimen showed increased amounts of glycogen particles, lipid droplets, and mitochondria that frequently contained paracrystalline inclusion bodies between intramitochondrial and extramitochondrial membranes. Involvement of the CNS was suspected from a computed tomography scan that revealed diffuse, low-density deep cerebral white matter. Therapy with corticosteroids (prednisolone) was effective for recovery of muscular strength in the extremities. Possible involvement of the CNS in ophthalmoplegia-plus might be related to an abnormal metabolism of mitochondria.

Adolescent↗
PubMed1981

Studies on microbial transformations. XVIII. Microbiological transformation of 1-alpha-santonin.

The microbial transformation of a sesquiterpene lactone, 1-alpha-santonin was carried out by Streptomyces roseochromogenes NRRL-B-1233. The product obtained from 1-alpha-santonin was purified using silica gel column chromatography with 1% acetone-benzene as the eluant. The molecular weight of the product was 248, estimated by mass spectroanalysis. The product was assigned the chemical structure of 1,2-dihydro-1-alpha santonin on the bases of 1H and 13C-NMR and mass spectroanalyses. Similar products were also obtained from other actinomycetes. The conversion of 1-alpha-santonin to 1,2-dihydro-1-alpha-santonin was 28% for Streptomyces roseochromogenes NRRL-B-1233, 14% for S. roseochromogenes ATCC 13400, 30.9% for S. aureofaciens KCC-S-0008, and 43.0% for S. aureofaciens KCC-S-0624, respectively.

Chromatography, Gel↗
PubMed1981

Carcinoma in situ of the vermiform appendix associated with adenomatosis of the colon.

A case is reported of carcinoma in situ of the vermiform appendix associated with adenomatosis of the colon. Histologic examination revealed the presence of tubulovillous adenocarcinoma in an adenoma. Other lesions associated with this neoplasm were multiple adenomatous polyps in the colon and duodenum and two fibromas in the neck. Since the vermiform appendix is a part of the large intestine, it should be expected that careful examination may reveal the adenomatous involvement and may lead to the discovery of carcinoma in situ.

Adenocarcinoma↗
PubMed1981

Endoscopic features of adenoma of the duodenal papilla in familial polyposis of the colon.

The duodenal papillae of 24 patients with familial polyposis of the colon were examined in detail by duodenofiberscopy and endoscopic biopsy. Adenomas were detected in 12 of the 24 patients (50%). Endoscopically the duodenal papilla had a white nodular or granular surface in most of the patients in whom adenoma was detected. In two patients, however, the endoscopic picture of the adenoma at the duodenal papilla was almost normal. Based on these observations, endoscopy and biopsy of the duodenal papilla should be added to the usual examination done in patients with this disease.

Adenoma↗
PubMed1981

Spontaneous nephroblastoma in Sprague-Dawley rats.

Pathological findings were described on nephroblastomas occurrred spontaneously in 3 young Sprague-Dawley rats. One side of kidneys was affected in each animal. Microscopically, the tumors consisted of epithelial elements showing undifferentiated to well-differentiated tubular arrangements, sometimes with glomeruloid and glomerular structures. A metastatic tumor nodule was found in the lung of one rat.

Animals↗