Search PubMed⌕ Search

Biomedical subjects

M Hossain

Publications and source records attributed to M Hossain.

At least 127 records · Page 7Linked to original sources
PubMed1991

Effect of pulsed electromagnetic field on healing of experimental nonunion in rat tibiae.

To see the effect of Pulsed Electromagnetic Field (PEMF) on nonunited fracture healing, nonunion was induced in rat tibiae and PEMF was applied on it. Out of five different techniques utilised for inducing nonunion soft tissue interposition was found to be the most suitable and effective method of experimental induction of nonunion. Twenty eight experimental and 15 control rats were finally evaluated for the effect of PEMF applied for up to 8 weeks. After sacrifice of 8 experimental and 4 controls, 6 experimental and 3 controls, again 6 experimental and 3 controls and finally 8 experimental and 5 controls at 2, 4, 6 and 8 weeks respectively of PEMF application no significant difference as to the quality of healing was observed between the experimental and control animals. It was thus concluded that PEMF appeared to have no beneficial effect on the healing of nonunited fractures in experimental set-up.

Animals↗
PubMed1990

Gastrointestinal transit of nondisintegrating, nonerodible oral dosage forms in pigs.

Gastrointestinal (GI) transit data necessary as "baseline" or "control" information were collected using pigs as animal models preliminary to bioavailability studies of new sustained action formulations. Density and size effects of nondisintegrating dosage forms on GI transit were investigated. Initially, enteric-coated nondisintegrating magnesium hydroxide caplets (density, 1.5 g/ml; size, 19.6 x 9.5 mm; weight, 1.2 g) were utilized in seven pigs. Prolonged gastric residence (greater than 5 days) occurred in every case for this dosage form. Therefore, nondisintegrating caplets of three densities (1.25, 1.45, and 2.3 g/ml) and three different sizes (large, 20 x 10 mm; medium, 10 x 10 mm; small, 5 x 10 mm) were studied in two more pigs. Roentgenography was used to visualize passage of caplets through the GI tract. Heidelberg pH capsules (size, 8 x 20 mm; density, 1.61 g/ml) were also used in this study. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate model for evaluating bioavailability of nondisintegrating controlled-release dosage forms because total GI transit time (especially gastric transit) is much too long.

Animals↗
PubMed1985

Lormetazepam (Loramet) in the elderly: an acceptability study.

In an open, single centre, general practice study, the short acting benzodiazepine lormetazepam (Loramet) was administered nightly for a period of 7 nights to fifty-eight geriatric insomniacs. All patients took 0.5 mg on the first night but were allowed to increase their dosage to 1.0 mg and 1.5 mg as required. The patients assessed the efficacy and acceptability of lormetazepam with the aid of a diary card completed on each morning of the study. The results showed that 65.5% of the patients reported an improvement in their sleep pattern and 76.9% were taking the 0.5 mg dosage by the last night of the study. Throughout the study there was a progressive increase in the mean duration of sleep and a similar increase in the number of patients awaking refreshed. The effects were significant after the second and third nights, respectively. Three patients withdrew from the study, two due to lack of efficacy and one dropped out following the occurrence of side-effects. It was concluded that the results confirm the efficacy and acceptability of lormetazepam and may suggest 0.5 mg to be a more suitable dosage than 1.0 and 1.5 mg in elderly patients.

Aged↗
PubMed1982

Rice-powder electrolyte solution as oral-therapy in diarrhoea due to Vibrio cholerae and Escherichia coli.

124 patients with acute diarrhoea due to Vibrio cholerae or Escherichia coli were treated with either the standard sucrose-electrolyte solution or a cereal-based electrolyte solution, containing 30 g rice powder per litre and electrolytes as recommended by the World Health Organisation. The treatments were compared by measuring the rate of purging, change in body weight, serum specific gravity, urine output, and post-hydrolysis sugar content in the stool. The proportions of successfully treated patients in the rice-powder group were 80% for cholera patients and 88% for E. coli patients--no different from those in patients receiving the sucrose-electrolyte solution. Failure was due to rates of purging that exceeded the patient's ability to drink enough replacement solution. This study suggests that a rice-powder electrolyte solution is efficient and safe to use as a rehydrating oral fluid in acute diarrhoea.

Adult↗
PubMed1982

Do all diuretics have equal hypotensive efficacy?

An open parallel study was carried out in general practice on 70 patients with uncomplicated mild to moderate hypertension to compare the hypotensive efficacy of hydrochlorothiazide/amiloride with that of cyclopenthiazide/potassium. After a 2-week baseline period on placebo, patients were allocated at random to receive treatment with one or other of the diuretics starting with 1 tablet per day and increasing up to a maximum of 4 tablets per day or until their supine diastolic blood pressure was 90 mmHg or less. They were then continued at their optimum dose for a further 4 weeks. Analysis of the results from 62 patients showed that the hydrochlorothiazide/amiloride preparation produced both a greater decrease and better control of blood pressure in a greater percentage of patients that did the comparison diuretic. In addition, the beneficial effects were attained with fewer tablets, of importance for patient compliance.

Adult↗
PubMed1979

18-substituted steroids. Part 4. A chemical synthesis of 3 alpha,18,21-trihydroxy-5 beta-pregnan-20-one 18--20-hemiacetal (18-hydroxy-tetrahydro-DOC).

3 alpha,18,21-Trihydroxy-5 beta-pregnan-20-one 18 leads to 20-hemiacetal (18-hydroxy-tetrahydro-DOC) has been prepared from 3 alpha-acetoxy-5 beta-pregnan-20-one by reduction to the 20 beta-alcohol, application of the 'hypoiodite' reaction [Pb(OAc)4-I2-hv] with subsequent steps leading to the 18-hydroxy-20-ketone (as hemiacetal), and C-21 acetoxylation [Pb(OAc)4] followed by hydrolysis.

18-Hydroxydesoxycorticosterone↗