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Biomedical subjects

M Horiguchi

Publications and source records attributed to M Horiguchi.

At least 163 records · Page 9Linked to original sources
PubMed1986

Pheochromocytoma and Ca++ channel blocker.

This is a case report of a 57-year-old woman who was diagnosed as suffering from pheochromocytoma on the basis of serum catecholamine levels, the results of abdominal echography and CT scanning. Her fluctuating blood pressure was treated successfully by intravenous administration of diltiazem. Diltiazem elicits a marked reduction in vascular resistance. There was no evidence that diltiazem affects catecholamine secretion levels, as reported by others for nifedipine.

Adrenal Gland Neoplasms↗
PubMed1985

Temporal aspects of the electroretinogram in cone-rod dystrophy.

Twelve patients with cone-rod dystrophy were studied in terms of the temporal aspects of electroretinography (ERG). The peak time of scotopic b-wave was within normal limits in all patients, while the amplitude was reduced in nine patients. The normal peak time of the scotopic-b wave may help explain rod involvement with normal or only slightly elevated final rod thresholds of subjective dark adaptation. The peak time of photopic b-wave and 30-Hz flicker response was normal in four patients and significantly delayed or nonrecordable in eight patients. Such variations of peak time in photopic and 30-Hz flicker ERG may reflect the stage of the disease or may be caused by the different hereditary mode.

Adult↗
PubMed1985

Response surfaces of body protein and energy gains in growing chicks fed diets over the entire range of compositions of protein, fat and carbohydrate.

Responses of metabolized energy, body protein gain and body energy gain of growing chicks to dietary composition of energy-yielding nutrients were studied. Twenty-seven groups of White Leghorn male chicks were force-fed purified isocaloric diets that covered the entire range of composition on a gross energy basis (0 to 100%) of protein, fat and carbohydrate for 10 d. Prediction equations of response surfaces of metabolized energy, body protein gain and energy gain were formulated by multiple regression techniques. The response surface of metabolized energy had a convex configuration and showed that the contribution rate of each energy-yielding nutrient to energy metabolizability varied with the levels of the three nutrients in the diet. Feeding protein-free diets especially diminished the metabolizability of carbohydrate and fat. The response surface of body energy gain was roughly parallel to that of metabolized energy, but the former was highly dependent on the caloric ratio of dietary carbohydrate to fat and reached a plateau at about 20% protein gross energy. Body protein gain increased almost linearly with an increase in protein in a low protein field, reaching a plateau at about 55% protein gross energy and was not very much affected by the calorie ratio of dietary carbohydrate to fat. In terms of energy-yielding nutrients, these results have provided an insight into the "balanced ration" for maximal body energy gain and body protein gain.

Animal Nutritional Physiological Phenomena↗
PubMed1984

The ultrastructural observation of a case of lymphomatoid papulosis.

Electron microscopic studies of biopsy specimens from a patient with lymphomatoid papulosis were performed. In the epidermis, infiltrating lymphoid cells, many of which had highly convoluted nuclei, were revealed to come into close contact to increased Langerhans' cells but did not accumulate to form microabscesses. In the dermis, Langerhans' cells with rather small numbers of Birbeck granules were scattered among the thick infiltration of mononuclear cells showing close apposition with lymphoid cells. Some macrophages contacted the Langerhans' cells and lymphoid cells were also observed. On one occasion, a Langerhans' cell clinged by a lymphoid cell in the uppermost dermis was revealed to expand the cytoplasm through the ruptured basal lamina touching another lymphoid cell in the epidermis.

Aged↗
PubMed1983

Nutritional interdependence among rumen bacteria during cellulose digestion in vitro.

A study has been made of the promoting effect of starch on cellulose digestion by mixed rumen bacteria in a cellulose-urea medium. Starch supplementation of the medium promoted the growth of bacteria that required neither amino acids (AA) nor branched-chain fatty acids (BrFA). The growth of these bacteria was followed by the growth of AA-dependent bacteria, AA- or BrFA-dependent bacteria, BrFA-producing bacteria, and finally, BrFA-dependent cellulolytic bacteria. Population changes of these bacterial groups corresponded with a cross-feeding of AA and BrFA and the overall disappearance of cellulose. The data suggest that the nutritional interdependence among rumen bacteria affects the rate of cellulose digestion.

Journal Article↗
PubMed1983

Alcoholic cardiomyopathy--acetaldehyde poisoning rat: myocardial and serum enzyme changes in acute exposure.

In order to clarify the pathogenesis of alcoholic cardiomyopathy, acetaldehyde (Ach) was administered to rats using the inhalation method. Serum enzyme changes and structural alterations of the heart were observed at various time intervals after 2 ml of Ach exposure for 2 hours. Possible myocardium-related enzymes, such as glutamic oxaloacetic transaminase, lactic dehydrogenase and creatine phosphokinase, were elevated within 24 hours and then returned almost to the previous levels. The most significant change seen using light microscopy was a prominent contraction band scattered throughout the specimen in the groups exposed for 12 and 24 hours, respectively. Ultrastructually, mitochondrial swelling and crystal disarray concomitant with myofibrillar change (swelling of Z-band) were observed. The former was seen most prominently immediately after exposure, while the latter was observed 24 hours after exposure. The significance of these findings and the difference between alcoholic cardiomyopathy and ischemic lesions were discussed.

Acetaldehyde↗